Recombinant Human NANS
- Known as:
- Recombinant Human NANS
- Catalog number:
- CF98
- Product Quantity:
- 10ug
- Category:
- -
- Supplier:
- Novoprotein
- Gene target:
- Recombinant Human NANS
Related genes to: Recombinant Human NANS
- Gene:
- NANS NIH gene
- Name:
- N-acetylneuraminate synthase
- Previous symbol:
- -
- Synonyms:
- SAS
- Chromosome:
- 9q22.33
- Locus Type:
- gene with protein product
- Date approved:
- 2002-12-16
- Date modifiied:
- 2018-07-06
Related products to: Recombinant Human NANS
Related articles to: Recombinant Human NANS
- Trafficking of secretory proteins from the endoplasmic reticulum (ER) to the Golgi apparatus comprises the first, essential steps towards the appropriate localization of 30% of eukaryotic proteins. Coat protein complexes COPII and COPI are involved in the forward and retrograde transport of cargo and cargo receptors between the ER and the Golgi, respectively. Although COPII forms coated vesicles in vitro, the biogenesis, morphology and organization of transport carriers in mammalian cells is subject to debate. Here we use in situ cryo-electron tomography and super-resolution fluorescence microscopy to reveal the molecular architecture of ER exit sites in human cells that were not perturbed with drugs, temperature blocks or overexpression systems. We visualize ribosome-exclusion zones enriched with COPII- and COPI-coated vesicles and thus resolve the debate regarding the existence of COPII-coated vesicles. COPII vesicles derive from ER membranes, whereas COPI vesicles originate from vesicular-tubular clusters that constitute the ER-Golgi intermediate compartment (ERGIC). We quantify coated vesicle morphology and positioning with respect to other ER exit site components, providing a molecular description of the organization of the mammalian early secretory pathway. - Source: PubMed
Publication date: 2026/05/20
Downes Katie WFlood Julia RNans AndreaVan der Verren Sander EAudhya AnjonZanetti Giulia - Microplastics (MPs) represent an important threat to rivers and exhibit complex patterns of accumulation and transport that depend mainly on environmental characteristics, among which hydrology plays a key role. However, the effects of flow intermittence on MP transport and accumulation remain unexplored. In this study, the normalized abundance by total organic carbon (TOC) of the sediment as well as the characteristics (i.e. size and polymer type) of MPs present in sedimentation areas within intermittent and perennial reaches of a small river catchment were compared. The effects of other environmental variables known to affect MP abundance and characteristics were also considered, such as land cover, grain size distribution of the sediment, distance to the road and to the hydrological source of the sampled reaches. The results showed both a negative and positive correlation between TOC normalized MP abundance and median size of MPs with the distance to the nearest road, respectively. This was likely due to the presence of small illegal dumps located near roads, that led to localized hotspots of streambed MP pollution in nearby rivers. Flow intermittence affected the size of MPs, with a negative correlation between the median MP size and flow intermittence, but no effect was detected on TOC normalized MP abundance and polymer diversity. This study offers new insights regarding the effects of flow intermittence in combination with other factors on the abundance and characteristics of streambed MPs. - Source: PubMed
Publication date: 2026/05/18
Barthelemy NansMermillod-Blondin FlorianLogez MaximeEme DavidKrause StefanDatry ThibaultSimon Laurent - Despite increasing representation of women in medicine overall, significant gender disparities persist in procedural specialties such as interventional pain medicine. Women remain underrepresented as speakers at national pain conferences and in leadership roles. Additionally, a pay gap between female and male pain physicians remains. This study aims to objectively demonstrate the above-mentioned inequities. - Source: PubMed
Catalanotto MarissaKim Serena JiyeonJaved Saba - Bone loss-related disorders, driven by impaired osteoblast activity, pose a growing global health challenge, yet current anabolic therapies remain limited due to an incomplete understanding of osteoblast dysfunction. Emerging evidence suggests that lactate-derived lysine lactylation-a glycolysis-linked PTM-may regulate osteoblast differentiation and bone homeostasis, though its landscape and functional impact in osteoblasts are largely unknown. Here, we integrated multi-omics profiling, Mendelian randomization (MR), and computational modeling to investigate lactylation-mediated osteogenic regulation. Using osteoblast models, we mapped dynamic proteomic and lactylome changes during differentiation, identifying 43 key proteins with concurrent alterations in expression and lactylation. Integrated MR analysis of human genetic data identified NANS and SPTLC1 as causal regulators of bone mineral density. Molecular dynamics simulations revealed lactylation-driven functional remodeling of these proteins, and network pharmacology suggested FDA-approved compounds (e.g., Suramin sodium and Paritaprevir) as potential osteogenic agents. This study advances mechanistic understanding of osteogenesis and provides a framework for discovering small molecules that mimic lactylation-induced conformational changes for drug repurposing in clinical applications. - Source: PubMed
Publication date: 2026/02/06
Chen RuijingGe SiliangChang FeifanChen MingLi YiLi YihuiYou DeshengTang PeifuYin Pengbin - HIV-1 integrase (IN) promotes encapsulation of viral genomic RNA into mature viral cores, and this function is a target for ongoing antiretroviral drug development efforts. Here we determined the cryogenic electron microscopy (cryo-EM) structure of a primate lentiviral IN in a complex with RNA, revealing a linear filament made of IN octamer repeat units, each comprising a pair of asymmetric homotetramers. The assembly is stabilized through IN-RNA interactions involving mainly the IN C-terminal domains and RNA backbone. The spacing and orientation of the IN filament repeat units closely matched those of consecutive capsid (CA) hexamers within the mature CA lattice. Using cryo-EM images of native purified HIV-1 cores, we refined the structure of the IN filament as it propagates along the luminal side of the CA lattice. Each IN tetramer within the filament nestled in a CA hexamer, engaging closely with the major homology regions. Substitutions of residues involved in IN-CA contacts yielded eccentric virions with RNA nucleoids located outside of the cores. Collectively, our results establish the structural basis for the HIV-1 IN-RNA interaction and reveal that IN forms an RNA-binding module on the luminal side of the mature CA lattice. - Source: PubMed
Publication date: 2026/02/18
Singer Matthew RLi ZhenRey Juan SHope JoshuaChenavier FlorianCook Nicola JPunch EmmaSmith JamieZhou ZhiyuMaslen SarahMasino LauraNans AndreaSkehel MarkTaylor Ian AZanetti GiuliaZhang PeijunPerilla Juan REngelman Alan NCherepanov Peter