Recombinant Human SERPINB5
- Known as:
- Recombinant Human SERPINB5
- Catalog number:
- CF94
- Product Quantity:
- 10ug
- Category:
- -
- Supplier:
- Novoprotein
- Gene target:
- Recombinant Human SERPINB5
Related genes to: Recombinant Human SERPINB5
- Gene:
- SERPINB5 NIH gene
- Name:
- serpin family B member 5
- Previous symbol:
- PI5
- Synonyms:
- maspin
- Chromosome:
- 18q21.33
- Locus Type:
- gene with protein product
- Date approved:
- 1994-06-20
- Date modifiied:
- 2016-04-06
Related products to: Recombinant Human SERPINB5
Related articles to: Recombinant Human SERPINB5
- Emphysema is a well-recognized risk factor for lung cancer; however, its influence on the immunologic tumor microenvironment in lung adenocarcinoma remains poorly defined. In this pilot, hypothesis-generating study, immune-related gene expression profiling was performed using archival formalin-fixed paraffin-embedded tumor specimens from 12 patients with lung adenocarcinoma, including the Never-smoker group (never-smokers without emphysema; = 4), the Smoker 1 group (smokers without emphysema; = 3), and the Smoker 2 group (smokers with CT-defined emphysema; = 5). Expression of 770 immune-related genes was analyzed using the nCounter PanCancer IO 360 Panel (NanoString Technologies, Seattle, WA, USA). Compared with the Never-smoker group, tumors from the Smoker 1 group showed marked upregulation of SFRP1, SERPINB5, and IL6, whereas tumors from the Smoker 2 group exhibited increased expression of KIR2DL3, BLK, and WNT2B. Relative to the Smoker 1 group, the Smoker 2 group demonstrated significant upregulation of MMP7, TDO2, and CCL18. Pathway enrichment analysis revealed cytokine-cytokine receptor interaction as the most prominently enriched pathway in both smoker groups, while the IL-17 signaling pathway was preferentially enriched in the Smoker 2 group. In addition, diffusing capacity for carbon monoxide showed significant correlations with immune-related genes including IL-6 and IL-6R. Collectively, these preliminary findings suggest that lung adenocarcinoma arising in emphysematous lungs may be characterized by a distinct pro-inflammatory immune microenvironment. Given the small sample size and potential confounders, these results should be regarded as hypothesis-generating. Emphysema-associated immune remodeling may nevertheless represent an important biological factor worthy of validation in larger, independent cohorts. - Source: PubMed
Publication date: 2026/04/29
Lim Jeong UkKim SeohyeonAn Tai JoonSa Young JoKim Hyo RimPark Chan KwonYoon Hyoung KyuKim Tae-Jung - - Source: PubMed
Pu TianFeng RanranWang ChunruZhao Ye - Invasive lobular carcinoma (ILC) accounts for 15% of breast cancers and presents challenges such as chemotherapy resistance and poorer survival outcomes compared to other subtypes. While often managed similarly to invasive ductal carcinoma (IDC), ILC requires tailored approaches due to its distinct biology. Ferroptosis, an iron-dependent form of cell death, shows potential in overcoming therapeutic resistance but remains unexplored in ILC. This study aimed to identify ferroptosis-related molecular subtypes, develop a robust gene signature using machine learning, construct an integrated prognostic model, and uncover potential therapeutic targets for ILC. - Source: PubMed
Publication date: 2026/02/25
Liu JunjieLi XiaoqianLi ZiyanZhang RuiLi XiaoduoFeng KexuanZhang WeiHe JianjunZhang Huimin - Soft tissue defects and injuries, such as gingival recession, those requiring dermal tissue filling, and other indications, affect millions worldwide, yet autologous grafting remains the standard of care in most instances, despite donor site morbidity and limited tissue availability. Tissue-engineered alternatives have strong potential to overcome these limitations. We evaluated an 8 mm-diameter, 1 mm-thick layered electrospun composite formed from polar/hydrophobic/ionic polyurethane with methacrylated gelatin (FD-PHI) and polycarbonate urethane (PCNU), seeded with a co-culture of human adipose-derived stem cells (ASCs) and microvascular endothelial cells (HAMVECs). A 1:2 HAMVEC:ASC ratio supported interconnected CD31 network formation and upregulated key proangiogenic factors (e.g., artemin, IL-1β, CXCL16, Serpin B5, leptin) after 7 days in vitro. Constructs were implanted subcutaneously into immunocompromised rats. Both cellular and acellular layered grafts integrated with the host tissue, aided by interlayer spacing facilitating tissue infiltration; however, cellular constructs exhibited significantly greater vessel density and diameter at 90 days. Pro-angiogenic proteins such as TGFBI, ITGAV, THY1, and PARVA were upregulated at early timepoints, which subsided over time, suggesting that a temporary upregulation may be sufficient to induce long-term outcomes for vascular function. Further proteomic analysis of the explants revealed an upregulation of laminin and collagen VI expression in cellular grafts, suggesting enhanced support for the development of the basement membrane. The work successfully shows the fabrication of a fully autologous EC and fibroblast-like co-culture, from a single adipose sample. This work holds promise as an alternative to current autologous grafting techniques, while overcoming challenges in preparing clinically applicable co-cultures. - Source: PubMed
Publication date: 2026/02/10
Webb Brian C WTran GenevieDevaraj KirtanaLindsay EmmaKuzmanov UrosGramolini Anthony OHofer Stefan O PSanterre J Paul - RNA 5-methylcytosine (mC) plays a critical role in cancer, yet its functional mechanisms and therapeutic relevance in cervical cancer remain unclear. Here, we generate the first base-resolution mC transcriptome maps in cervical cancer, revealing globally elevated mC levels in tumors. By integrating spatial transcriptomics and single-cell RNA-seq, we identify SERPINB5 as a novel mC-regulated oncogenic effector. mC modification enhances SERPINB5 mRNA stability and protein expression, promoting tumor growth, metastasis, and resistance to microtubule-targeting chemotherapeutics. Mechanistically, SERPINB5 upregulates mitotic regulators and microtubule motor proteins, including CENPE, enhancing mitotic progression and counteracting drug-induced mitotic arrest. Loss-of-function experiments demonstrate that SERPINB5 depletion sensitizes cervical cancer cells to paclitaxel and vincristine, while its reintroduction restores chemoresistance even in mC-deficient cells. Our study uncovers a previously unrecognized mC-SERPINB5 axis as a central driver of cervical cancer malignancy and chemoresistance, highlighting SERPINB5 as a clinically actionable target to improve outcomes for patients receiving microtubule-targeting chemotherapy. - Source: PubMed
Publication date: 2026/02/11
Liu JiejieZhou LiminYao PeipeiZhang NanGuo XiaoChen FeiYang ShiminDu XinWang HongyunZhou YouChen YuZhou Li