SW60_TLS_55 Tubes with short caps
- Known as:
- SW60_TLS_55 Tubes short caps
- Catalog number:
- 1054116
- Product Quantity:
- 1 pack
- Category:
- -
- Supplier:
- Accu
- Gene target:
- SW60_TLS_55 Tubes with short caps
Related genes to: SW60_TLS_55 Tubes with short caps
- Gene:
- CAPS NIH gene
- Name:
- calcyphosine
- Previous symbol:
- -
- Synonyms:
- CAPS1, MGC126562
- Chromosome:
- 19p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1990-05-31
- Date modifiied:
- 2016-07-18
Related products to: SW60_TLS_55 Tubes with short caps
Related articles to: SW60_TLS_55 Tubes with short caps
- New therapies are needed for posttraumatic stress disorder (PTSD), particularly in military service members (SMs). Reconsolidation of traumatic memories (RTM) is a novel treatment with promising results in small clinical trials. We randomized 94 active duty or retired SMs (M = 45.80, 31.0% women) with PTSD to receive up to ten 90-min sessions of RTM (n = 48) or prolonged exposure (PE; n = 46) to ascertain whether RTM achieved a greater and/or faster response. The Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) was used to establish eligibility and assess response at 2 weeks and 2, 6, and 12 months postintervention. The PTSD Checklist for DSM-5 was administered before Sessions 2, 4, 6, 8, and 10 to assess response rapidity. We hypothesized that RTM would achieve quicker responses and higher loss of diagnosis rates than PE. From baseline to postintervention, participants in both the RTM (39.13 vs. 22.38), d = 1.42, p < .001, and PE groups (39.26 vs. 22.45), d = 1.50, p < .001, showed improvement on the CAPS-5, with no between-group difference, p = .959. Response (RTM: 74.2%, PE: 72.4%), loss of diagnosis (RTM: 58.1%, PE: 51.7%), and withdrawal (RTM: 18.8%, PE: 32.6%) rates showed no significant differences. Gains were largely sustained through 12 months. RTM had more early responders (72.2%) than PE (27.8%), p = .005; 70.0% of participants addressed multiple traumas with RTM versus 30.0% for PE, p = .022. RTM and PE demonstrated comparable large effect sizes, but RTM achieved more early responses. - Source: PubMed
Publication date: 2026/04/27
Roy Michael JBellini Paula GRaboy Annabel LeeDunbar Kerri ESpangler Patricia TDempsey Catherine LSatter Rachel MTravers BarbaraHaight ThaddeusAdams Deborah ProbeGray Richard M - The co-occurrence of mild traumatic brain injury (mTBI) and posttraumatic stress disorder (PTSD) is associated with greater impairment relative to the presence of either condition alone. This study evaluated the effectiveness of cognitively augmented behavioral activation (CABA) therapy, compared to treatment as usual (TAU), at reducing mTBI and PTSD symptoms in 71 military veterans randomized to treatment at two urban U.S. Department of Veterans Affairs medical centers. Primary outcomes were PTSD symptom severity, measured by structured clinical interview (Clinician-Administered PTSD Scale for DSM-5; CAPS-5) and self-report questionnaire (PTSD Checklist for DSM-5; PCL-5), and objective cognitive function (neuropsychological test battery). Intent-to-treat analyses using linear mixed-effects regression models (LMM) indicated that CABA significantly outperformed TAU in reducing PTSD symptom severity, CAPS-5: d = 0.11, p = .027, PCL-5: d = 0.11, p = .030 (small effects), and improving performance on neuropsychological tests of verbal learning, d = 0.07 (small effect) and delayed recall, d = 0.26 (small-to-medium effect). Changes in PTSD symptoms were explored via within-group LMM, which revealed significant within-CABA reductions, CAPS-5: d = 0.87, p < .001, PCL-5: d = 0.40, p = .006 (medium-to-large effects), but no significant symptom change within the TAU group, CAPS-5: d = 0.07, p = .195, PCL-5: d = 0.00, p = .978 (small effects). There was no significant difference between groups on treatment satisfaction ratings. This randomized controlled trial provides preliminary evidence that CABA may be a promising intervention for comorbid mTBI and PTSD. - Source: PubMed
Publication date: 2026/04/27
Callahan Megan LRau Holly KWagner Amy WJakupcak MatthewGolshan ShahrokhStorzbach DanielFann Jesse REngel DavidPagulayan Kathleen F - Host receptors can detect traces of non-self-pathogenic RNAs within a sea of cellular mRNA molecules. In host cells, mRNA cap methylation occurs in the nucleus, generating Cap1 and Cap2 structures (mGpppNm and mGpppNmNm, respectively). By contrast, alphavirus genomes carry a Cap0 structure (mGpppN), which lacks 2'-O-methylation. This difference in the structure of the host and viral caps serves as a molecular signature that enables discrimination between self and non-self RNAs. Several host immune sensors, such as RIG-I and IFIT1, recognize the alphavirus Cap0 structure and trigger an antiviral response to restrict viral replication. It has been proposed that IFIT1 sequesters aberrant RNAs, preventing their translation by host ribosomes and blocking viral protein synthesis. However, alphaviruses have evolved molecular strategies to circumvent IFIT1-mediated restriction and facilitate infection in mammalian cells. One such strategy involves the folding of a 5' RNA structure that hides the cap from host immune sensors. This highlights the dynamic interplay between viral evasion tactics and host immune defenses. This review will discuss how specific modifications at the 5' end of alphavirus RNA modulate host defenses and how a deeper understanding of the virus-host interaction may inform the development of novel vaccine strategies. - Source: PubMed
Publication date: 2026/04/05
Faraj Santiago EFilomatori Claudia V - : Sensorimotor differences have frequently been reported in children with developmental dyslexia, but are often considered secondary or comorbid to phonological deficits. Within an embodied cognition perspective, reading acquisition emerges from dynamic interactions between bodily regulation, multisensory integration, and learning-related neural plasticity. Proprioception contributes to spatial orientation, motor coordination, and perceptual stabilization, while sleep-dependent processes play a critical role in the consolidation and automatization of cognitive and motor skills. : Building on early clinical observations, including the hypothesis proposed by Martins da Cunha, this review explores whether variations in proprioceptive processing and sensorimotor regulation may influence multisensory stability and the conditions under which reading skills develop in some individuals with dyslexia. : This narrative synthesis integrates clinical observations and experimental paradigms examining proprioceptive function in children with dyslexia, including studies conducted in our laboratory over the past two decades. These investigations address postural regulation under varying attentional demands, laboratory measures of proprioceptive acuity, visuospatial localization tasks, multisensory interactions, and exploratory observations concerning sleep-wake regulation. : Across studies, children with dyslexia often show differences in proprioceptive processing associated with variations in postural regulation, visuospatial stability, and multisensory tasks. Laboratory measurements suggest reduced proprioceptive acuity in some individuals, with moderate correlations observed between proprioceptive sensitivity and reading-related measures. Additional observations suggest that nocturnal physiological regulation-including respiratory dynamics and sleep architecture-may interact with daytime sensorimotor stability and attentional functioning. : Taken together, these findings support the hypothesis that variations in sensorimotor regulation across the sleep-wake cycle may influence the stability of multisensory processing and attentional conditions relevant for reading acquisition. Within this perspective, proprioception is not proposed as an alternative explanation for dyslexia but as a complementary dimension that may contribute to the heterogeneity of dyslexic profiles. Further longitudinal and controlled studies are required to clarify the relationships between sensorimotor regulation, sleep-dependent plasticity, and learning processes. - Source: PubMed
Publication date: 2026/03/24
Quercia Patrick - To evaluate the relationship between pre-incarceration social determinants, demographic and clinical factors, and glycaemic control in African Americans with a history of criminal legal involvement and type 2 diabetes mellitus. - Source: PubMed
Publication date: 2026/04/26
Akinboboye OlaitanWalker Rebekah JCampbell Jennifer AHawks LauraWilliams Joni SEgede Leonard E