PSMB9 Rabbit IgG antibody Ab Purified
- Known as:
- PSMB9 Rabbit Immunoglobulin G (anti-) Antibody Purified
- Catalog number:
- GTX106601
- Product Quantity:
- 0.1 ml
- Category:
- -
- Supplier:
- ACR
- Gene target:
- PSMB9 Rabbit IgG antibody Purified
Related genes to: PSMB9 Rabbit IgG antibody Ab Purified
- Gene:
- PSMB9 NIH gene
- Name:
- proteasome subunit beta 9
- Previous symbol:
- LMP2
- Synonyms:
- RING12, beta1i, PSMB6i
- Chromosome:
- 6p21.32
- Locus Type:
- gene with protein product
- Date approved:
- 1991-12-18
- Date modifiied:
- 2016-10-05
Related products to: PSMB9 Rabbit IgG antibody Ab Purified
Related articles to: PSMB9 Rabbit IgG antibody Ab Purified
- Rapidly progressive pneumoconiosis (RPP) is an aggressive subtype of pneumoconiosis characterized by persistent pulmonary inflammation, rapidly progressive fibrosis, and early-onset progressive massive fibrosis. However, the systemic molecular alterations of RPP remain unclear. Here, we profiled the plasma proteome to identify candidate proteins associated with RPP, aiming to discover potential peripheral biomarkers for this aggressive phenotype. - Source: PubMed
Publication date: 2026/08/14
Tang MeianLuo YufeiLi YingTang WeiweiYi XiaZhang XiaohuaWang LimingChen Rou - Human papillomavirus (HPV) infection is a major contributor to cervical cancer (CC), yet the molecular mechanisms driving HPV-associated immune evasion remain largely undefined. - Source: PubMed
Guo RuiHe WentingLiu XiaZhang Na - Proteasome β (PSMB) subunits are essential components of the proteasome complex and play important roles in antigen processing and immune regulation. In this study, we identified 14 Psmb genes in grass carp (Ctenopharyngodon idella), including seven constitutive Psmbs (Psmb1-7), three immunoproteasome genes (Psmb8-10), two thymoproteasome-related paralogs (Psmb11a and Psmb11b), and two telelost-specific members (Psmb12 and Psmb13). Comparative genomic analyses showed that grass carp Psmb genes are highly conserved in genomic organization, gene synteny, and predicted β-subunit-like protein structures, supporting the evolutionary conservation of the proteasome β-subunit family in fish. Phylogenetic and syntenic analyses further revealed lineage-specific expansion of immunoproteasome-related Psmb genes in teleost fish, with Psmb12 and Psmb13 likely derived from duplications of Psmb9 and Psmb10, respectively. Tissue expression analysis suggested functional divergence among duplicated Psmb members, as constitutive Psmbs were relatively enriched in the brain, whereas immunoproteasome-related and teleost-specific Psmbs were highly expressed in immune- and mucosa-associated tissues. Moreover, GCRV-I infection rapidly induced Psmb8-10 and Psmb11b expression in CIK cells. IFN-γ induced a broader set of Psmb genes than IFNa, whereas IL-10 selectively suppressed several Psmbs. Together, these findings highlight the evolutionary conservation, expansion, and immune-related diversification of the Psmb family in teleost fish. - Source: PubMed
Publication date: 2026/08/22
Xu JingGao WaJia ZhaoFeng JianhuaLei WenjingZhu LiwenYan HuiZhuo PeilinWang JunyaZou Jun - As a core component of the immunoproteasome, the β1i subunit (proteasome 20S subunit beta 9, PSMB9) is involved in antigen processing and presentation and regulates anti-tumor immune responses. PSMB9 is aberrantly overexpressed in colorectal cancer. However, the precise mechanisms through which PSMB9 contributes to the initiation, progression, and immune regulation of colorectal cancer remain unclear. This study aims to investigate the expression characteristics and biological functions of PSMB9 in colorectal cancer, and to further elucidate the molecular pathways underlying its role in colorectal cancer initiation and progression. The findings are expected to provide a theoretical basis for the development of targeted therapeutic strategies against colorectal cancer. PSMB9 expression in colorectal cancer was analyzed using the TCGA, GEO, GEPIA, and HPA databases, and further validated in normal colonic epithelial cells and colorectal cancer cell lines by RT-qPCR and Western blot. Lentiviral transduction was used to establish stably transduced HCT116 and SW480 cell lines with PSMB9 knockdown and overexpression, respectively. Cell proliferation, migration, and invasion were assessed by CCK-8, colony formation, wound healing, and Transwell assays. Key proteins of the PI3K/Akt signaling pathway were detected by Western blot. PSMB9 was significantly upregulated at both the mRNA and protein levels in colorectal cancer tissues and cell lines. PSMB9 knockdown significantly inhibited the proliferation, migration, and invasion of colorectal cancer cells, while overexpression enhanced these malignant phenotypes. Mechanistically, PSMB9 exerted oncogenic effects through activation of the PI3K/Akt signaling pathway. PSMB9 promotes the malignant progression of colorectal cancer by regulating the PI3K/Akt signaling pathway. - Source: PubMed
Publication date: 2026/08/13
Gao WenZheng XingyuHu YananZou RuiZhou YonganSong Xiang - Immune escape drives cancer progression and therapy resistance, yet its prognostic role and impact on the tumor immune microenvironment in thyroid cancer remain unclear. We integrated single-cell and bulk RNA sequencing data to systematically characterize immune escape and its clinical significance. scRNA-seq analysis characterized cellular heterogeneity and quantified immune escape activity via AUCell. A prognostic gene signature was constructed from differential expression analysis combined with univariate Cox and LASSO regression, and validated using Kaplan-Meier and time-dependent ROC analyses. The immune landscape was profiled using ssGSEA, CIBERSORT, and ESTIMATE, while immunophenoscore (IPS) was used to predict immunotherapy responsiveness. Functional enrichment, CellChat, SCISSOR, tumor mutation burden (TMB), and CellMiner analyses were further performed to explore underlying mechanisms and therapeutic implications. A three-gene signature (CD9, NPC2, PSMB9) effectively stratified patients into highand low-risk groups with distinct survival outcomes. Low-risk tumors exhibited an "immune-hot" phenotype with increased CD8+ T cells and activated NK cells, higher checkpoint expression, and elevated IPS, suggesting greater immunotherapy sensitivity. In contrast, high-risk tumors showed an immune-cold microenvironment with M2 macrophage enrichment. Despite higher TMB, high-risk tumors displayed reduced immune activity, indicating impaired immune recognition. Single-cell analysis further identified MIF and CCL signaling as key mediators of multicellular immune evasion. Overall, our single-cell-informed immune escape signature provides a promising framework for thyroid carcinoma risk stratification and offers insights into personalized immunotherapy. - Source: PubMed
Publication date: 2026/08/12
Jiang LingZou LiuyiLiu FeiqiXiong DonglinYi Chenggen