ZAP70 Mouse antibody Ab Purified
- Known as:
- ZAP70 Mouse (anti-) Antibody Purified
- Catalog number:
- AM20165PU-N
- Product Quantity:
- 50
- Category:
- -
- Supplier:
- ACR
- Gene target:
- ZAP70 Mouse antibody Purified
Related genes to: ZAP70 Mouse antibody Ab Purified
- Gene:
- ZAP70 NIH gene
- Name:
- zeta chain of T cell receptor associated protein kinase 70
- Previous symbol:
- SRK
- Synonyms:
- ZAP-70, STD
- Chromosome:
- 2q11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1995-05-16
- Date modifiied:
- 2019-04-23
Related products to: ZAP70 Mouse antibody Ab Purified
Related articles to: ZAP70 Mouse antibody Ab Purified
- Cholangiocarcinoma (CCA) has a complex tumor microenvironment (TME) and poor immunotherapy response. Understanding how the adaptive immune response (AIR) affects the TME and prognosis is critical. - Source: PubMed
Publication date: 2026/07/06
Jie WangJixiang ZhouYang BaoYanting WangLing Liu - Tumor-infiltrating lymphocytes (TILs) shape melanoma behavior and response to immunotherapy, but the links between immune regulation, TIL patterning, and outcomes remain unclear. We retrospectively studied 32 primary melanoma samples from patients treated with anti-PD-1 therapy. Histopathologic TILs were classified as brisk or non-brisk, and primary tumors underwent targeted immune transcriptomic profiling (NanoString nCounter Human Immunology panel). External validation was performed with 96 TCGA-SKCM primary tumors. Brisk tumors displayed broad upregulation of immune transcripts, with enrichment of adhesion pathways (directed global significance scores - DGSS = 2.15) and MHC class II antigen presentation (DGSS = 2.128). Cross-cohort comparison identified 22 shared differentially expressed genes, with ZAP70 remaining significant in both datasets. Brisk tumors also showed higher total TIL (p = 0.036), cytotoxic-cell (p = 0.0095), and Th1 (p = 0.027) scores. Response-associated genes differed by TIL pattern, and subgroup-specific gene scores predicted anti-PD-1 benefit in brisk (4-gene, Area under curve - AUC = 1.000) and non-brisk (3-gene, AUC = 0.852) tumors; the non-brisk score remained independently associated with response (p = 0.029). Higher scores were also associated with prolonged survival. Integrating histopathological TIL patterning with immune transcriptomics may refine prognostication and support immunotherapy stratification in melanoma. - Source: PubMed
Publication date: 2026/07/15
de Souza Vinícius GonçalvesSorroche Bruna PereiraTeixeira Renan de JesusNunes HendrigoLaus Ana CarolinaVazquez Vinícius de LimaLosada Daniele MoraesArantes Lidia Maria Rebolho Batista - Targeting the neuro-immune microenvironment to suppress triple-negative breast cancer (TNBC) represents a critical strategy in tumor immunotherapy. - Source: PubMed
Publication date: 2026/07/13
Li Fei-FeiHuang YanGao Chun-FangWu Chun-YuSun Chen-PingQin Yue-NongXie YingLiu ShengWu Huan-Gan - Site-level resolution of protein phosphorylation remains a central challenge in decoding cellular signaling and conventional global phosphoproteomics is limited in its ability to detect low-abundance peptides and resolve positional isomers. Here we introduce sequence-selective synthetic receptors based on imprinted polymers for targeted enrichment of defined phosphopeptide motifs from complex cancer cell proteomes. By encoding local sequence context into the binding interface, these receptors enable selective capture of closely related phosphorylation sites with high specificity. Using the T cell kinase ZAP70 as a model, we resolve phosphorylation at adjacent tyrosine residues (pY492 and pY493) within a regulatory motif, overcoming a long-standing limitation in site discrimination. Integrated with liquid chromatography-mass spectrometry workflows, this enables sensitive detection of low-abundance and isomeric phosphopeptides that evade conventional enrichment strategies. More broadly, our findings establish molecular imprinting as a programmable chemical platform for site-resolved phosphoproteomics, opening new avenues to interrogate signaling networks with molecular precision. - Source: PubMed
Publication date: 2026/07/13
İncel AnılShinde SudhirkumarArribas Díez IgnacioStollenwerk Maria MXu JingjingRavnsborg TinaJakobsson Magnus EJensen Ole NSellergren Börje - T cell activation relies on the precise spatiotemporal regulation of T cell receptor (TCR) signaling at the immunological synapse, where vesicular trafficking coordinates the delivery of key signaling molecules. Endosomal pools of lymphocyte-specific protein tyrosine kinase (Lck) and its immediate substrate, the TCRζ chain, have been linked to TCR signaling competence, yet the mechanisms that regulate and coordinate their trafficking routes remain unresolved. - Source: PubMed
Publication date: 2026/07/08
Karpouzou KonstantinaKoutras NikolaosTyritidis IoannisTsioupros EvangelosKotini Andriana GRoukos VassilisNika Konstantina