ZAP70 Mouse IgG1 antibody Ab Ascites
- Known as:
- ZAP70 Mouse IgG1 (anti-) Antibody Ascites
- Catalog number:
- AM06119SU-N
- Product Quantity:
- 0.1 ml
- Category:
- -
- Supplier:
- ACR
- Gene target:
- ZAP70 Mouse IgG1 antibody Ascites
Related genes to: ZAP70 Mouse IgG1 antibody Ab Ascites
- Gene:
- ZAP70 NIH gene
- Name:
- zeta chain of T cell receptor associated protein kinase 70
- Previous symbol:
- SRK
- Synonyms:
- ZAP-70, STD
- Chromosome:
- 2q11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1995-05-16
- Date modifiied:
- 2019-04-23
Related products to: ZAP70 Mouse IgG1 antibody Ab Ascites
Related articles to: ZAP70 Mouse IgG1 antibody Ab Ascites
- NOD-like receptor family pyrin domain-containing 6 (Nlrp6) is an inflammasome related molecule expressed in intestinal epithelial and immune cells. While previous work showed that Nlrp6 in host nonhematopoietic cells exacerbates gastrointestinal acute graft-versus-host disease (aGVHD), its role in donor T cells remained unclear. Here we show that donor T cell-intrinsic Nlrp6 exerts a protective effect in murine aGVHD models. Mice receiving Nlrp6 deficient (Nlrp6-/-) donor T cells had reduced survival and more severe GVHD than those receiving wild-type T cells. Mechanistically, Nlrp6-/- T cells showed enhanced proliferation, preferential Th1 differentiation, and upregulation of Th1 cytokines. Enhanced phosphorylation of Zap-70 and Erk1/2 indicated hyperactivation of proximal TCR signaling. Despite increased aGVHD, graft-versus tumor (GVT) responses preserved in Nlrp6-/- T cells. Clinically, T cells from aGVHD patients showed decreased Nlrp6 expression, supporting the relevance of our findings. Collectively, these data suggest that Nlrp6 negatively regulates allogeneic donor T cell responses, via Zap-70-Erk1/2 signaling, while sparing anti-tumor immunity. We conclude that beneficial effects of Nlrp6 expression in donor T cells opposes the detrimental Nlrp6 effects in intestinal epithelial cells during aGVHD indicating Nlrp6 has cell type-specific and context-dependent antagonistic biological functions on controlling aGVHD inflammatory responses. - Source: PubMed
Publication date: 2026/07/02
Matsuki EriMiyata MasahiroSato RyoGawron JanaSuto MasahiroTamaki HiroyaFujiwara HideakiIto AiHishima TsunekazuIshizawa YukiSekiguchi ErikaTobai TayuUshio SaeOravecz-Wilson KatherineChen GraceTawara IsaoIchikawa KazunobuWatanabe MasafumiIshizawa KenichiYokoyama HisayukiPeltier DanielBlazar BruceZeiser RobertReddy PavanToubai Tomomi - Head and neck squamous cell carcinoma (HNSCC) is one of the most prevalent malignant tumors worldwide and presents significant challenges due to its high rates of recurrence, metastasis, and poor prognosis. Emerging evidence suggests that eosinophil extracellular traps (EETs)-related genes may play a crucial role in tumor progression and aggressiveness. Consequently, investigating the intersection between HNSCC and EETs-related genes and constructing a prognostic model may offer valuable clinical insights. This study aims to identify the key genes that play a significant role in the eosinophil extracellular trap of HNSCC, and to construct a prognostic model to guide treatment. - Source: PubMed
Publication date: 2026/05/27
Han ChuyuLuo XuechengXiao ShouyinLv JiaouWang BinLi Zhilin - Polycyclic aromatic hydrocarbons (PAHs), ubiquitous environmental pollutants, are considered significant environmental factors contributing to the pathogenesis of RA. Benzo[a]pyrene (BaP), a key component of PAHs, may be associated with RA onset; however, the underlying toxicological mechanism remains to be fully elucidated. In this study, we systematically addressed this knowledge gap using an integrated approach combining network toxicology, machine learning, and molecular docking. Initially, a network toxicology analysis was conducted based on the molecular structure of BaP. By integrating and screening target information from multiple databases, 15 potential RA-related target genes of BaP were ultimately identified, and their interaction network was constructed. GO and KEGG enrichment analyses revealed that these genes were significantly enriched in biological processes such as leukocyte migration and immune cell signal transduction and were associated with the NF-κB and T cell receptor signaling pathways, among others. Subsequent topological analysis using the STRING database and Cytoscape software screened out five core genes (LCK, ZAP70, ITK, GZMA, and ITGAL), whose importance was further validated through machine learning. Molecular docking and molecular dynamics simulation results indicated that BaP exhibits strong binding affinity for the protein products of these target genes, resulting in the formation of conformationally stable complexes. In summary, this study employs an integrated computational approach to elucidate the potential mechanisms by which BaP may contribute to RA development, thereby offering a theoretical foundation for future investigations into the prevention and treatment of RA associated with environmental pollutants. - Source: PubMed
Publication date: 2026/05/26
Han YuxinChen GuangyaoLi WeichaoWu HaoluLi JieYang HuilanWang ManniLiu YiWang JianmingZhang Yanzhen
- Source: PubMed
- Acute Myeloid Leukemia (AML) is driven by complex interactions between genetic mutations and epigenetic dysregulation. While alterations in chromatin modifiers are frequent, the precise downstream transcriptional networks they enable and how these networks execute the leukemogenic program remain incompletely defined. - Source: PubMed
Publication date: 2026/05/30
Zeng LihuaLei HaohaoBi JingnanRun GuoweiYu BizhenJi Linhua