NFAT5 pSer1197 Rabbit antibody Ab Aff - Purified
- Known as:
- NFAT5 pSer1197 Rabbit (anti-) Antibody Aff - Purified
- Catalog number:
- A1220-2
- Product Quantity:
- 0.1 mg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- NFAT5 pSer1197 Rabbit antibody Aff - Purified
Related genes to: NFAT5 pSer1197 Rabbit antibody Ab Aff - Purified
- Gene:
- NFAT5 NIH gene
- Name:
- nuclear factor of activated T cells 5
- Previous symbol:
- -
- Synonyms:
- TONEBP, KIAA0827, NFATL1, OREBP, NFATZ, NF-AT5
- Chromosome:
- 16q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-07-16
- Date modifiied:
- 2019-04-23
Related products to: NFAT5 pSer1197 Rabbit antibody Ab Aff - Purified
Related articles to: NFAT5 pSer1197 Rabbit antibody Ab Aff - Purified
- Organ maturation is a fundamental biological process and a major challenge for organoid-based regenerative medicine. During kidney maturation, osmolality increases in the renal medulla for urine concentration, yet whether this extreme environment conversely contributes to kidney maturation remains unclear. Here we show that high tonicity, i.e., salt, drives morphological, transcriptional, and functional maturation of medullary collecting ducts (CDs) primarily via nuclear factor of activated T cells 5 (NFAT5). This occurs both in vitro and in vivo. Combining high tonicity with maturation-promoting hormones, we establish a robust maturation protocol for human medullary CD organoids and a functional assay to measure water permeability in CD organoids, enabling modeling of three disease states: NFAT5 deletion, and lithium-induced and congenital nephrogenic diabetes insipidus. Collectively, high tonicity drives mammalian kidney maturation, offering a promising platform to maximize the potential of organoids for future therapies. - Source: PubMed
Publication date: 2026/10/02
Inoue DaisukeMiike KoichiroTanigawa ShunsukeYasunaga Kei-IchiroMaeda RaeOhmori TomokoFujimura SayokoMukoyama MasashiKamba TomomiAramburu JoseLopez-Rodriguez CristinaSugiura YukiIzumi YuichiroNishinakamura Ryuichi - The long non-coding RNA is known to regulate various cellular processes; however, its role in porcine adipose tissue remains largely unexplored. In this study, we examined in pigs differing in fat-deposition traits by combining promoter sequencing, in silico analysis of transcription factor binding site analysis, expression profiling, and in vitro adipogenesis assays. We identified three novel polymorphisms in the promoter regions. Several SNPs were predicted to alter binding sites for transcription factors related to metabolism and immunity, such as , , and . One variant, rs329590882, differed significantly in frequency between breeds and may influence regulation. During adipocyte differentiation, expression of the isoform ENSSSCT00000080860 increased as adipogenesis progressed. Notably, this isoform was more highly expressed in lean-type Pietrain pigs than in the fatty Złotnicka Spotted (ZS) breed, suggesting that its function may not be directly related to fat accumulation. Additionally, we identified novel exon-exon junctions in , including a junction associated with the ENSSSCT00000077869 isoform. These findings provide new insights into the potential role of in porcine adipose tissue development and immunometabolic regulation and highlight the need for improved annotation of porcine lncRNAs. - Source: PubMed
Publication date: 2026/07/29
Piórkowska KatarzynaOcłoń EwaWróblewska KseniaZygmunt KarolinaPawlicki PiotrPardyak Laura - Macrophage-driven inflammatory programs and NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome plays a critical role for periodontal tissue destruction; however, the transcriptional regulators that mediate these responses remain unclear. This study therefore examined the role of the microRNA-1260b (miR-1260b)-nuclear factor of activated T-cells 5 (NFAT5) axis in inflammatory macrophage responses relevant to periodontal disease. - Source: PubMed
Publication date: 2026/08/04
Hayashi ChikakoFukuda TakaoShida MiyuXiao MengWang ZiyuRyo NaoakiToyoda MasaakiKawakami KentaroShinjo TakanoriAoki TsukasaLi JinfengAhmad MwannnesTaketomi TakaharuUchiumi TakeshiSanui TerukazuNishimura Fusanori - Oral submucous fibrosis (OSF) is a chronic, potentially malignant disorder strongly associated with areca nut chewing. Cuproptosis, a newly identified form of cell death, may play a role in OSF progression, but the mechanisms remain unclear. This study aimed to explore the involvement of cuproptosis in OSF. Here, we observed a significant increase in cuproptosis markers (FDX1 and LIAS) in OSF lesion tissues compared to normal oral mucosa. In vitro, arecoline induced cuproptosis predominantly in epithelial cells, characterized by increased FDX1 and LIAS expression, disrupted lipoylation of DLAT, and elevated intracellular Cu²⁺ accumulation. An epigenetic modification PCR array revealed that arecoline most markedly upregulated PUS1, a pseudouridine (Ψ) modification synthase. Functional knockdown of PUS1 alleviated arecoline-induced cuproptosis, as evidenced by reduced Cu²⁺ levels and restored lipoic acid expression. Dot blot and PA-ψ-seq further demonstrated that arecoline-induced PUS1 upregulation altered the global tRNA pseudouridylation landscape, with enrichment of Ψ peaks in Wnt- and copper transport-related transcripts. PUS1 knockdown markedly attenuated arecoline-induced β-catenin nuclear localization and the upregulation of MYC, FZD6, CTNNB1, NFAT5, SLC25A39, and VDAC2. In conclusion, we reveal a previously unrecognized mechanism whereby arecoline promotes OSF via PUS1-dependent pseudouridylation remodeling and epithelial cuproptosis, offering novel therapeutic targets for OSF intervention. - Source: PubMed
Publication date: 2026/07/27
Lin ShigengDeng WeiWen QitaoXu Xiongjun - Plumage coloration in birds is a complex genetic trait involving both direct pigmentation genes and their modifiers. The Columbian pattern, characterized by black feathers restricted to the neck, wing tips, and tail, remains poorly understood at the genetic level. This study aimed to conduct a genome-wide association study of the Columbian pattern across 29 chicken breeds of diverse origins. Blood samples were collected from breeds with ( = 11) and without ( = 18) the Columbian pattern. Genotyping was performed using the Illumina Chicken 60K SNP chip, and GWAS was conducted using EMMAX with Bonferroni correction. A total of 10 significant and nine suggestive SNPs on chromosomes GGA1, 2, 5, 7, 10, and 11 were identified. Eight significant SNPs mapped to a ~0.7 Mb region on GGA11 containing and multiple functionally diverse genes involved in melanocyte adhesion (), signaling (, ), transcription (, ), protein degradation (, ), and vesicular trafficking (). On GGA2, a significant SNP within a lncRNA gene was located in a QTL for yellow plumage, with positional candidates (, , , , ) suggesting links to pheomelanin deposition. A suggestive locus near on GGA5 was also identified. This study refines the genetic architecture of the Columbian pattern, implicating a core region on GGA11 modulating melanocyte function and a distinct locus on GGA2 involved in pheomelanin synthesis. - Source: PubMed
Publication date: 2026/07/11
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