TG-101348 Mechanisms: JAK2 inhibitor
- Known as:
- TG-101348 Mechanisms: JAK2 suppressor
- Catalog number:
- A-1140
- Product Quantity:
- 5mg
- Category:
- -
- Supplier:
- Activ
- Gene target:
- TG-101348 Mechanisms: JAK2 inhibitor
Related genes to: TG-101348 Mechanisms: JAK2 inhibitor
- Gene:
- JAK2 NIH gene
- Name:
- Janus kinase 2
- Previous symbol:
- -
- Synonyms:
- JTK10
- Chromosome:
- 9p24.1
- Locus Type:
- gene with protein product
- Date approved:
- 1992-04-16
- Date modifiied:
- 2019-04-23
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Related articles to: TG-101348 Mechanisms: JAK2 inhibitor
- The cardiovascular-kidney-metabolic (CKM) syndrome framework integrates the shared pathophysiology of cardiovascular disease, excess adiposity, diabetes, and chronic kidney disease into a unified staging framework. Clonal haematopoiesis of indeterminate potential (CHIP), the age-related expansion of hematopoietic stem cells harbouring somatic mutations, has been linked to several CKM components, but its relationship with CKM syndrome is unknown. - Source: PubMed
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Chang AnnieLi LinkeEzzat DanielFlynn SpencerDe Moor NoreHemeryck JanMohammadnia NiekbachshSchuermans ArtYu ZhiLiu YixuanUddin Md MesbahNatarajan PradeepHonigberg Michael C - Selaginella tamariscina (P. Beauv.) Spring is a traditional Chinese herbal medicine used to treat hematemesis, metrorrhagia, hematochezia, rectal prolapse, and other diseases. Based on its efficacy in treating bloody stools, S. tamariscina is also used in formulations for ulcerative colitis (UC). - Source: PubMed
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Xue ChuLi XinLu ZhaowenHuang JinZhao YanWang LeminLi NanCao Zhengyu - Asthma is a complex, heterogeneous, and inflammatory disease with an increasing incidence worldwide. This study aimed to investigate the therapeutic mechanisms of sophocarpine in asthma systematically. - Source: PubMed
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Zhi WenbingZhang HongQiao ZiyaoJiang ShengnanLiang ZongsuoLiu Yang - This study investigated the molecular characteristics and functions of buffalo prolactin (PRL) in the lactation. The buffalo gene's complete coding sequence (CDS) is 690 bp, encoding 229 amino acids, with structure and function highly consistent with other Bovidae species. expression was significantly higher in the buffalo mammary gland during lactation compared to the non-lactating period, highlighting its crucial role in lactation. overexpression in buffalo mammary epithelial cells (BuMECs) promotes cell proliferation and increases the casein secretion and triglyceride (TAG) accumulation. This occurs through the activation of the JAK2-STAT5 (cell differentiation, casein () gene transcription, and lipid factor transcription), PI3K-AKT-mTOR (cell growth, milk protein gene translation, and lipid factor activation), and mitogen-activated protein kinase (MAPK; cell proliferation and stress mitigation) signaling pathways. Specifically, overexpression upregulated the mRNA expression of genes in these pathways, such as , , , , , , and , while decreasing and . Overexpression also increased the expression of cell cycle genes (, , /), and enhanced cell viability. Furthermore, overexpression led to increased expression of casein genes (, ) and milk-fat-synthesis-related genes (, , , , ). Population genetic analysis identified five single-nucleotide polymorphisms (SNPs) in the buffalo CDS, with c.34C T and c.430T C being non-synonymous substitutions that were predicted to affect protein function. This research provides a theoretical foundation for genetic interventions aimed at improving buffalo lactation traits. - Source: PubMed
Publication date: 2025/12/03
Huang LigeFan XinyangTeng XiaohongQian LindongBao ZhipengMiao Yongwang - - Source: PubMed
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Ashmawy Ahmed IEl-Abhar Hanan SAbdallah Dalaal MAli Mennatallah A