Mouse FVII _ Factor VII _ F7 Protein
- Known as:
- Mouse FVII _ Factor VII _ F7 Protein
- Catalog number:
- 10312-M01C
- Product Quantity:
- 20μg
- Category:
- -
- Supplier:
- Provo
- Gene target:
- Mouse FVII _ Factor VII F7 Protein
Related genes to: Mouse FVII _ Factor VII _ F7 Protein
- Gene:
- F8 NIH gene
- Name:
- coagulation factor VIII
- Previous symbol:
- F8C
- Synonyms:
- FVIII, DXS1253E, HEMA
- Chromosome:
- Xq28
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2019-04-23
Related products to: Mouse FVII _ Factor VII _ F7 Protein
Related articles to: Mouse FVII _ Factor VII _ F7 Protein
- Poxviruses are double-stranded DNA viruses with large genomes. Among them, monkeypox virus (MPXV) has been responsible for two recent public health emergencies as declared by the World Health Organization. The MPXV polymerase comprises three subunits-a catalytic subunit (F8) and a heterodimeric processivity factor (A22 and E4). The viral polymerase must coordinate activities with the hexameric helicase-primase (E5) to initiate replication of the viral genome. Although structures of MPXV E5 (refs. ) and the polymerase in isolation are available, how they assemble into a functional replisome remains unclear. In isolation, E5 is in an autoinhibited conformation and has very weak helicase activity, and the mechanism for helicase activation is unclear. Here we used cryo-electron microscopy to determine the structures of DNA-bound MPXV replisomes comprising the polymerase holoenzyme (F8, A22 and E4) and the E5 helicase hexamer. We show that, during replisome assembly, E5 undergoes large-scale conformational changes that allow two of its primase domains to interact with the polymerase F8 thumb and A22 subunit. Biochemical assays and single-molecule experiments reveal that this E5 conformational change is coupled to helicase activation and enhances primase activity. Taken together, these findings identify fundamental mechanisms governing coordinated helicase and polymerase activities during DNA replication for an important class of viral pathogens. - Source: PubMed
Publication date: 2026/09/02
Yu ZishuoSathyanarayana PradeepTan Joel M JHu SideFan XiaoyiGao AngelaKranzusch Philip JLoparo Joseph JAbraham Jonathan - Life satisfaction is a key component of successful aging. This study investigated the correlates of life satisfaction in a sample of 127 older adults (M = 73.1 years, SD = 5.4) from Sardinia, an Italian island known for successful aging. Participants were assessed for global cognitive efficiency, perceived health, lifestyle habits, life satisfaction, and specific cognitive functions using the digital screening tool DIGICOG-MS. After controlling for age, education, and global cognitive efficiency, life satisfaction was significantly associated with perceived health, time spent on hobbies, verbal semantic fluency, auditory verbal learning, and immediate recall via DIGICOG-MS. A hierarchical regression analysis showed that perceived physical health, time spent on hobbies, verbal fluency, auditory verbal learning, and immediate recall were significant predictors of life satisfaction, accounting for approximately 20% of the variance (Adjusted R = 0.198, F(8,117) = 4.860, p < .001). Interestingly, greater usability of DIGICOG-MS was associated with lower levels of education, suggesting that the tool is highly intuitive and successfully mitigates the educational barriers often encountered in traditional paper-and-pencil neuropsychological assessments. In conclusion, these findings highlight the role of subjective health, engagement in leisure activities, executive functions, auditory verbal learning, and immediate recall in shaping life satisfaction in late adulthood, supporting the potential of DIGICOG-MS as a tool for community-based cognitive screening in older populations. - Source: PubMed
Publication date: 2026/09/02
Fastame Maria ChiaraAtzori AnnaDi Dio MartinaPau MassimilianoSusini AlessiaPodda Jessica - - Source: PubMed
Publication date: 2026/08/31
Jamwal ManuRay DebadritaKaur PavneetSharma RitikaSenee Hari KishanHans ChanderBansal DeepakPeyam SrinivasanJain ArihantKumar NarenderDas ReenaAhluwalia Jasmina - Human adipose tissues are solid organs distributed throughout the body in specific locations and are thought to have dichotomous functions: white adipose tissue stores triglycerides as an energy reservoir, and brown adipose tissue uses metabolic fuels to generate heat. To define the transcriptional profile of six principal adipose depots, we analyze tissue from 11 autopsies (3 F/8 M, 16-71 y) of patients who had different underlying diseases. Despite global similarities in terms of cell type proportions, each depot has a distinct transcriptomic signature and functional profile. Each human's adipose tissues are more similar to each other than to the anatomically and functionally matching depots in other patients. The transcriptomic pattern of subcutaneous white adipose tissue can even be used to predict the human donor. This pattern suggests that individualized factors such as genetics, age, environment, diet, and disease play impactful roles in coordinating the behavior of the whole-body adipose tissue depot. - Source: PubMed
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Nguyen NhuquynhCero CherylGuarnieri Adrienne RKim Ju HeeLong Kelly THeymann JurgenAli Sahara LLeary Emily VCypess Aaron M - : Restrictive eating behaviors during early adolescence may increase the risk of disordered eating, yet little is known about modifiable family and social factors influencing these behaviors. This study investigated associations between maternal parenting strategies, weight teasing, and restrictive eating behaviors among 168 Hispanic mother-daughter dyads. : Mothers and daughters independently completed surveys assessing demographic and acculturation characteristics, and their height and weight were objectively measured. Mothers also completed the parenting strategies measures, while daughters completed the weight teasing and restrictive eating behaviors measures. : Descriptive analyses indicated that 66.1% of mothers and 98.9% of daughters were classified in either the overweight or obese categories. Hierarchical multiple regression analyses showed that greater use of maternal limit-setting strategies was associated with lower levels of restrictive eating behaviors in daughters ( = -0.213, = 0.017), whereas more frequently perceived weight teasing was associated with greater restrictive eating behaviors ( = 0.404, < 0.001). The final model was statistically significant, (8, 126) = 5.139, < 0.001, explaining 19.8% of the variance in daughters' restrictive eating behaviors. : These findings suggest that interventions that strengthen supportive parenting strategies and reduce weight stigma may help prevent restrictive eating behavior in this population. - Source: PubMed
Publication date: 2026/08/20
Olvera NormaMatthews-Ewald Molly RRoy Tamal JScherer RhondaFan WeihuaArbona Consuelo