Human IGF-I Protein Vector: HEK293
- Known as:
- Human IGF-I Protein Vector: HEK293
- Catalog number:
- 10211-H04H
- Product Quantity:
- 100μg
- Category:
- -
- Supplier:
- Provo
- Gene target:
- Human IGF- Protein Vector: HEK293
Related genes to: Human IGF-I Protein Vector: HEK293
- Gene:
- AIRN NIH gene
- Name:
- antisense of IGF2R non-protein coding RNA
- Previous symbol:
- -
- Synonyms:
- AIR, NCRNA00088, IGF2RAS, IGF2R-AS1
- Chromosome:
- 6q25.3
- Locus Type:
- RNA, long non-coding
- Date approved:
- 2008-11-25
- Date modifiied:
- 2018-08-15
- Gene:
- CCN1 NIH gene
- Name:
- cellular communication network factor 1
- Previous symbol:
- IGFBP10, CYR61
- Synonyms:
- GIG1
- Chromosome:
- 1p22.3
- Locus Type:
- gene with protein product
- Date approved:
- 1998-03-02
- Date modifiied:
- 2018-10-11
- Gene:
- CCN2 NIH gene
- Name:
- cellular communication network factor 2
- Previous symbol:
- CTGF
- Synonyms:
- IGFBP8
- Chromosome:
- 6q23.2
- Locus Type:
- gene with protein product
- Date approved:
- 1992-12-01
- Date modifiied:
- 2018-10-11
- Gene:
- CCN3 NIH gene
- Name:
- cellular communication network factor 3
- Previous symbol:
- NOV
- Synonyms:
- IGFBP9
- Chromosome:
- 8q24.12
- Locus Type:
- gene with protein product
- Date approved:
- 1993-11-05
- Date modifiied:
- 2018-10-11
- Gene:
- FCGR2A NIH gene
- Name:
- Fc fragment of IgG receptor IIa
- Previous symbol:
- FCG2, FCGR2A1, FCGR2
- Synonyms:
- CD32, CD32A, IGFR2, CDw32
- Chromosome:
- 1q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 1988-11-30
- Date modifiied:
- 2019-04-23
Related products to: Human IGF-I Protein Vector: HEK293
Related articles to: Human IGF-I Protein Vector: HEK293
- Spinocerebellar ataxia type 3 (SCA3) is a progressive neurodegenerative disorder for which reliable metabolic biomarkers are lacking. Insulin-like growth factor binding protein 1 (IGFBP1), a stress-responsive protein regulated by insulin signaling, serves as an indicator of neurodegenerative burden. The present study aimed to measure the plasma levels of insulin, glucose, IGF1, IGF2, IGFBP1, IGFBP3 and neurofilament light chain (NfL) in patients with genetically confirmed SCA3 and age-matched controls. In addition, the association between the above molecules and clinical severity were assessed using the scale for the Assessment and Rating of Ataxia score, body mass index (BMI) and NfL levels, whereas metabolic-neurodegenerative interactions were assessed by stratifying patients by insulin tertiles. A total of 32 individuals with SCA3 and 36 age- and sex-matched controls were enrolled in the current study. The results demonstrated that patients with SCA3 exhibited markedly elevated IGFBP1, IGF2 and free IGF1 levels, as well as reduced insulin and higher glucose-to-insulin ratios, thus indicating disrupted insulin signaling. IGFBP1 was positively associated with SARA score and NfL levels and negatively associated with BMI. Notably, patients in the lowest insulin tertile (<3.65 µIU/ml) showed significantly higher IGFBP1 and NfL levels compared with the remaining groups, thus suggesting that the insulin/IGFBP1/NfL axis was associated with ataxia severity. Collectively, IGFBP1 could be a promising peripheral biomarker reflecting both metabolic and neurodegenerative processes in SCA3 and could facilitate monitoring of disease stages. - Source: PubMed
Publication date: 2026/02/10
Chiu ChungminCheng WenlingLin TatsungChang HuijuChang YujunSu ShihliLee ChiajuChang HenhongLiu Chinsan - Insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBPs) regulate cell proliferation, differentiation, metabolic processes, and immune activities. Psoriasis is a systemic inflammatory disease with metabolic disorders as an important comorbidity in the pathogenesis of which members of the IGF family could also play a role. Therefore, we decided to evaluate the levels of members of the IGF signaling pathway in patients with psoriasis. Sixty-nine people were enrolled in our study: 34 patients with psoriasis and 35 controls. The following parameters were evaluated in serum obtained from peripheral blood: total cholesterol, triglycerides, high-density lipoprotein, fasting glucose, IGF-1, IGF-1R, IGF-2, IGF-2R, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, and insulin. The levels of several parameters differed between groups. The levels of fasting glucose, insulin, IGFBP3, and IGFBP6 were higher in patients with psoriasis, while the levels of IGF-1, IGF-1R, and IGBP4 were higher in controls. The results suggested that the IGF-1 signaling pathway can be involved in the pathogenesis of psoriasis and its comorbidities, especially metabolic disorders such as insulin resistance, diabetes, and metabolic syndrome. The novelty of our study is in its comprehensive assessment of the involvement of the IGF-1 signaling pathway in the pathogenesis of psoriasis and advances the understanding of the pathogenesis of psoriasis and its comorbidities. - Source: PubMed
Publication date: 2026/02/02
Drahomira HolmannovaLenka BorskaZdenek FialaJan KrejsekKvetoslava HamakovaEva CermakovaVit RehacekOndrej FialaTereza MaresovaPavel Borsky - Heterosis, also known as hybrid vigour, is widespread in animals. It is complex and primarily regulated by a variety of tissues related to the growth axis, but the molecular bases for this phenomenon remain elusive. - Source: PubMed
Publication date: 2026/01/09
Hu BinNie YingLi LinfengLi XiaopingLuo JunyiChen TingXi QianyunZhang YongliangSun Jiajie - Somatotropic gene expression has been altered by genetic selection, and developmental changes in insulin-like growth factor (IGF) and IGF binding protein (IGFBP) expression may contribute to rapid growth and muscle accretion in commercial broilers. The objective of this study was to evaluate changes in somatotropic axis activity between embryonic day (e) 12 and post-hatch day (d) 21. Liver and breast muscle (pectoralis major) were collected to measure gene expression, and blood was collected post-hatch to measure circulating IGFs. Liver IGF1 rose rapidly post-hatch and, in muscle, IGF1 exhibited a dynamic expression pattern. Levels decreased from e14 to e20, returned to e14 levels at d3, decreased again at d10, and stayed low thereafter. In both tissues, mRNA levels of several IGFBPs changed between embryogenesis and post-hatch. Liver IGFBP2 increased between e12 and e20, returned to e12 levels on d1, and remained low. Conversely, liver IGFBP4 expression was greater post-hatch than during embryogenesis. Expression of select IGFBPs was depressed in liver during the peri-hatch period. Liver IGFBP1, IGFBP3, IGFBP5, and IGFBP7 mRNA levels all decreased around this time and returned to embryonic levels by d3. In breast muscle, expression of both IGFBP2 and IGFBP4 was reduced after hatch. Circulating insulin-like growth factor IGF1 and IGF2 levels did not change between hatch and d21. These data suggest that post-hatch IGF effects are likely modulated by target tissue IGFR1 and IGFBP expression rather than changes in circulating hormone levels, with promotion or restriction of IGF-receptor binding regulating growth. Downregulation of several IGFBPs synthesized in the liver may facilitate the metabolic transition from utilizing yolk lipids to dietary carbohydrates. Several IGFBPs produced in breast muscle appear to have growth-promotive effects during embryogenesis but restrict growth of this tissue after hatch, as their post-hatch downregulation could facilitate local IGF signaling. These developmental gene expression patterns suggest that somatotropic hormonal signaling regulating growth and muscle accretion might be controlled through differential actions of IGFBPs and provide a basis for future functional studies. - Source: PubMed
Publication date: 2024/08/05
Vaccaro Lauren AHerring KyleWilson AbigailEngland EmmaSmith Addison LEllestad Laura E - Hybridization and polyploid breeding are the main approaches used to obtain new aquaculture varieties. Allotriploid crucian carp (3n) with rapid growth performance was generated by mating red crucian carp (RCC) with allotetraploids (4n). Fish growth is controlled by the growth hormone (GH)/insulin-like growth factor (IGF) axis. In the present study, we examined the expression characteristics of GH/IGF axis genes in hybrids F, 4n, 3n, RCC and common carp (CC). The results showed that GHRa, GHRb, IGF1, IGF2, and IGF-1Ra were highly expressed in 3n compared with RCC and CC, whereas IGF3 was undetectable in the liver in RCC, CC and 3n. GHRa and GHRb had low expression in the 4n group. In hybrid F, GHRa expression was low, whereas GHRb was highly expressed compared to the levels in RCC and CC. Moreover, in hybrid F, the expression of IGF3 was higher, and the expression of IGF1 and IGF2 was lower than that in the RCC and CC, whereas the expression of IGF-1Ra was similar to that in RCC and CC. For the IGFBP genes, IGFBP1 had higher expression in 3n compared than that in RCC and CC, while other IGFBP genes were not high expressed in 3n. Among the genes detected in this study, 11 genes were nonadditively expressed in 3n, with 5 genes in the transgressive upregulation model. We proposed that the 11 nonadditive expression of GH/IGF axis genes is related to growth heterosis in 3n. This evidence provides new insights into hybridization and polyploid breeding from the perspective of hormone regulation. - Source: PubMed
Publication date: 2024/03/26
Qing WeilingRen BingxinLou ChenyiZhong HuanZhou YiLiu Shaojun