Human E-Selectin _CD62E Protein Vector: HEK293
- Known as:
- Human E-Selectin _CD62E Protein Vector: HEK293
- Catalog number:
- 10086-H01H
- Product Quantity:
- 200μg
- Category:
- -
- Supplier:
- Provo
- Gene target:
- Human E-Selectin _CD62E Protein Vector: HEK293
Related genes to: Human E-Selectin _CD62E Protein Vector: HEK293
- Gene:
- SELE NIH gene
- Name:
- selectin E
- Previous symbol:
- ELAM1, ELAM
- Synonyms:
- ESEL, CD62E
- Chromosome:
- 1q24.2
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-30
- Date modifiied:
- 2015-08-25
Related products to: Human E-Selectin _CD62E Protein Vector: HEK293
Related articles to: Human E-Selectin _CD62E Protein Vector: HEK293
- : Pleural and peritoneal mesothelioma (PL and PE) are aggressive diseases, accounting for 68.0-92.4% and 6.9-24.1% of all cases. To improve both diagnosis and management of these patients, a deeper knowledge and characterization of the molecular background are necessary. Although molecular profiling of PL has been largely investigated in recent years, much less is known about the genomic landscape of PE, due to its rarity. Here, we aim to compare gene expression profiling of pleural and peritoneal mesothelioma to underline main differences and to identify new potential histotype-specific biomarkers. : We performed a gene expression analysis of 32 epithelioid PL and 21 epithelioid PE cases, diagnosed from 2017 to 2023 at the University Hospital of Pisa, using an nCounter custom panel including 117 target genes known for their crucial role in cancer. PE, compared to PL, showed different expression levels of genes related to extracellular matrix modification (), as collagen alteration, pro-inflammatory and angiogenic response (mediated by NF-κB). In detail, in PE we observed a significant upregulation of metalloproteinase-1 (), E-selectin (), pappalysin-1 (), estrogen receptor-2 () and transportin-2 (); and a downregulation of pyruvate kinase (). Furthermore, BAP1 loss was associated with distinct gene deregulation in PE and PL; the only exception was upregulation, which was observed in both histologies. These insights may help refine the utility of as a biomarker. : Deregulated genes in PE deserve further investigation as potential biomarkers, according to their biological role. In fact, and impact migration ability and angiogenic response of mesothelioma, while and are usually investigated for their involvement in reprogramming of energy metabolism. The identification of histotype-specific biomarkers is warranted to improve mesothelioma management. - Source: PubMed
Publication date: 2026/09/17
Sparavelli RebeccaPoma Anello MarcelloFaviana PinucciaUgolini ClaraLucchi MarcoLippolis Piero VincenzoAlì GretaBruno Rossella - Tissue edema results from excessive interstitial fluid accumulation driven by inflammatory responses and increased vascular leakage. This study investigated the protective effects of HY7801 (HY7801) against inflammatory activation, endothelial barrier dysfunction, and edema formation and . In lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages, HY7801 reduced nitrite accumulation and expression. In tumor necrosis factor-α (TNF-α)-stimulated human umbilical vein endothelial cells (HUVECs), HY7801 increased nitrite accumulation and expression, suppressed the expression of endothelial adhesion molecules (, , and ) and , and enhanced the expression of the tight junction-associated genes ( and ). Furthermore, HY7801 partially restored transendothelial electrical resistance (TEER), an indicator of endothelial barrier integrity, following TNF-α-induced impairment. In a λ-carrageenan-induced mouse paw edema model, HY7801 treatment attenuated paw swelling, histological tissue thickening, and vascular leakage. These effects were accompanied by increased junction-associated gene expression in inflamed paw tissue and reduced circulating inflammatory mediators. Based on these anti-inflammatory and endothelial barrier-protective effects, HY7801-derived extracellular vesicles (HY7801 EVs) were further evaluated as a candidate bioactive component of HY7801. HY7801 EVs enhanced and expression while suppressing , , and expression. Collectively, our findings suggest that HY7801 attenuates inflammation-associated tissue edema and vascular leakage through coordinated modulation of inflammatory and endothelial barrier responses, and support a potential role for HY7801 EVs as a bioactive component contributing to these effects. - Source: PubMed
Publication date: 2026/09/18
Lee DaehyeopJeong HaerynGwon HyeonjunBaik JiminKim Joo-YunShim Jae-JungLee Jae-Hwan - A high triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio is strongly associated with insulin resistance and atherosclerotic cardiovascular risk, but the cellular mechanisms linking this lipid imbalance to vascular injury remain incompletely defined. This study established a combined hyperglycemic/high TG/low HDL-C ratio-mimetic in vitro model using human coronary artery endothelial cells and THP-1-derived macrophages to investigate endothelial inflammation, glycocalyx disruption, monocyte recruitment, foam-cell formation, oxidative stress, and cholesterol efflux. High TG/low HDL-C ratio-mimetic stress significantly reduced endothelial viability, increased cytotoxicity, impaired transendothelial resistance, increased fluorescein isothiocyanate (FITC)-dextran permeability, and promoted syndecan-1 shedding. The lipid-stress condition induced endothelial inflammatory activation, with increased vascular cell adhesion molecule 1 (VCAM1), intercellular adhesion molecule 1 (ICAM1), E-selectin (SELE), C-C motif chemokine ligand 2 (CCL2), interleukin 6 (IL6), and C-X-C motif chemokine ligand 8 (CXCL8) expression, accompanied by enhanced THP-1 adhesion and transmigration. Glycocalyx and junctional injury were supported by increased heparanase (HPSE) expression and reduced syndecan-1 (SDC1), tight junction protein 1 (TJP1), cadherin 5 (CDH5), wheat germ agglutinin (WGA) staining, zonula occludens-1 (ZO-1) continuity, and vascular endothelial cadherin (VE-cadherin) integrity. Endothelial-conditioned lipid stress promoted macrophage foam-cell formation, increased CD36 scavenger receptor (CD36), oxidized low-density lipoprotein receptor 1 (OLR1), and peroxisome proliferator-activated receptor gamma (PPARG) expression, enhanced cholesterol accumulation, and suppressed ATP-binding cassette transporter A1 (ABCA1)-, ATP-binding cassette transporter G1 (ABCG1)-, scavenger receptor class B member 1 (SCARB1)-, and apolipoprotein E (APOE)-associated cholesterol efflux pathways. HDL rescue broadly attenuated endothelial inflammation, oxidative stress, barrier disruption, and macrophage foam-cell formation, whereas ApoA-I exerted protective effects across the selected endothelial and macrophage endpoints in which it was evaluated. CD36 inhibition reduced macrophage lipid accumulation, whereas heparanase inhibition preserved glycocalyx integrity. These findings identify the endothelial glycocalyx-nuclear factor kappa B (NF-κB)-CD36/ABCA1 axis as a mechanistic link between the high TG/low HDL-C ratio and diabetic atherosclerotic vascular dysfunction. - Source: PubMed
Publication date: 2026/09/10
Bi LechangZhao WenLu MingjingJiang NanWang GaofengHuang FeilaiLuo PengchaoWang Guofu - Post-thrombotic syndrome (PTS) develops in 20% to 50% of patients following deep vein thrombosis (DVT) due to persistent vein wall injury, inflammation, and fibrotic remodeling. Current anticoagulant therapies do not directly address PTS pathogenesis and carry bleeding risks. We characterized the extracellular matrix (ECM) components and evaluated whether pharmacological inhibition of α6β1 integrin with pranlukast (PLK) could modulate post-thrombotic vein wall injury in a preclinical DVT model. - Source: PubMed
Publication date: 2026/09/04
Taylor Alessia LMoreno OscarLuke Catherine EPellerito MatteaPellerito AntonioPatel NehaliCai QingRocco SabrinaMyers Daniel DWakefield ThomasObi Andrea THenke Peter - Tungiasis is a neglected tropical zoonotic skin disease which is endemic to Sub-Saharan Africa and Latin America, caused by sand fleas of the genus Tunga, which burrow into the skin of affected humans and animals, most commonly when the feet come in contact with infested soil. Sand flea infection leads to inflammation, severe itching, and pain, with the potential for secondary bacterial or viral infections, gangrene, and disfigurement. Tungiasis disproportionately affects poor rural communities, and individuals living in unhygienic settlements. To date, the existing burden of tungiasis has never been estimated, despite being included in the World Health Organisation Neglected Tropical Diseases roadmap since 2021. - Source: PubMed
Publication date: 2026/08/31
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