Human IL13RA1 _CD213A1 Protein Vector: HEK293
- Known as:
- Human IL13RA1 _CD213A1 Protein Vector: HEK293
- Catalog number:
- 10081-H01H
- Product Quantity:
- 100μg
- Category:
- -
- Supplier:
- Provo
- Gene target:
- Human IL13RA1 _CD213A1 Protein Vector: HEK293
Related genes to: Human IL13RA1 _CD213A1 Protein Vector: HEK293
- Gene:
- IL13RA1 NIH gene
- Name:
- interleukin 13 receptor subunit alpha 1
- Previous symbol:
- -
- Synonyms:
- IL-13Ra, NR4, CD213a1
- Chromosome:
- Xq24
- Locus Type:
- gene with protein product
- Date approved:
- 1998-03-26
- Date modifiied:
- 2015-12-11
Related products to: Human IL13RA1 _CD213A1 Protein Vector: HEK293
Related articles to: Human IL13RA1 _CD213A1 Protein Vector: HEK293
- Intradermal injections of anti-canine immunoglobulin E (IgE) in healthy dogs have been utilized in preclinical drug testing to evaluate the efficacy of anti-allergic drugs used to treat canine atopic dermatitis (AD). However, the molecular effects of established canine anti-allergic drugs on this acute canine IgE-mediated atopic model remain largely uninvestigated. The objective of this study was to characterize the effect of proactive oclacitinib and prednisolone treatments on the immune and skin barrier transcriptome of IgE-mediated late-phase reactions (LPRs) in an acute model of canine AD. Sixteen healthy adult research-bred beagles were randomized to receive either oclacitinib or prednisolone orally for six days, followed by an intradermal anti-canine IgE injection. Biopsies were collected 24 h post-injection for RNA isolation and sequencing; previously analyzed transcriptomes (healthy skin, saline-injected skin, IgE lesions without drug modulation) from the same colony of dogs served as controls. Administration of prednisolone and oclacitinib prior to intradermal anti-IgE injections reduced the number of differentially expressed genes (DEGs) in 24 h samples to 1251 and 1471, respectively. Both treatments resulted in a decrease in expression of several significantly upregulated T helper-(Th)1 (e.g., , , ), Th2 (e.g., , , , , , ), chemokine and receptor (e.g., , , , , ) genes in comparison to the untreated IgE-mediated lesions. Interestingly, only prednisolone treatment significantly reduced upregulation, an important gene in the Th2 immune response. In conclusion, both prednisolone and oclacitinib reduced the transcriptomic changes observed in the acute lesions of the canine IgE-induced atopic dermatitis model, with prednisolone inducing a broader inhibitory immune response. - Source: PubMed
Publication date: 2026/07/13
Leon RenatoBlubaugh AmandaStarr HaleyBanovic Frane - Atopic dermatitis (AD) is characterized by peripheral inflammation and intense pruritus. While itch-induced brain activation in AD is documented, our previous work revealed aberrant resting-state activation in the left superior frontal gyrus (LSFG). However, whether this central dysfunction is linked to peripheral immune status remains unclear. - Source: PubMed
Publication date: 2026/06/26
Dai WenyuXue ShengjieHuang XinLong XuanLou LouWang BolunWu HaishanLiao Jieyue - Cutaneous allergen sensitization (CAS) is a primary driver of atopic dermatitis (AD) and a key initiator of the "atopic march", which can lead to systemic conditions such as food allergy and anaphylaxis. The type 2 cytokine interleukin-13 (IL-13) is an important regulator of high-affinity IgE antibodies, yet the precise cellular targets and mechanisms by which it orchestrates systemic allergic responses remain incompletely understood. Here, we evaluated the role of IL-13 in a murine CAS model that links skin inflammation to systemic anaphylaxis. Using cell-specific deletions of the IL-13 receptor α1 subunit (), we identify conventional dendritic cells (cDCs), and not T or B cells, as the essential targets of IL-13 for generating high-affinity IgE. Single-cell transcriptomics reveal that IL-13 signaling acts specifically in a cDC2 subset characterized by high expression of CX3CR1, Clec10a (CD301a), and CD301b (Mgl2). Licensing by IL-13 endows these cDC2 with superior antigen-presenting capacity, characterized by the upregulation of MHC class II and costimulatory molecules, including CD301a, CD301b, and ICOSL. These mature cDC2s are mobilized from the periphery to the spleen by a CX3CR1-dependent mechanism, where they are uniquely equipped to induce the differentiation of IL-13-producing T follicular helper (T13) cells. This cascade results in robust germinal center reactions and production of pathogenic, high-affinity IgE. Our findings define an IL-13-cDC2 axis that functions as a critical regulator of the atopic march, providing a mechanistic rationale for the clinical efficacy of IL-13-targeted therapies in allergic diseases. - Source: PubMed
Publication date: 2026/07/09
Harada YasuyoSasaki TakanoriObata-Ninomiya KazushigeMatsuyama TakahiroUeha SatoshiShichino ShigeyukiWatanabe TakashiOgawa ShuheiKi SewonSuzuki YoshieIto NaotoMotomura YasutakaUeno HidekiZiegler Steven FInoue HiromasaBurrows PeterKim Brian SMurphy Kenneth MKubo Masato - Breast cancer (BRCA) is a common malignant tumor that seriously threatens women's health. Studies have shown that histone modifications (HMs) play a vital role in the occurrence and development of BRCA. This study aims to explore the distribution patterns of HMs in the mammary epithelial cell line (HMEC) and breast cancer cell line (MCF-7), and their potential associations with gene expression, patient prognosis, and drug efficacy. - Source: PubMed
Publication date: 2026/06/01
Cao YanniLi XiaohuiLiu JiangshanZhang JunyuanXu KangchengLin HaoLiu Yuxian - Eosinophilic gastritis (EoG) is a chronic inflammatory disease characterized by infiltration of eosinophils and mast cells, epithelial remodeling, and fibrosis. Although EoG is increasingly recognized as a distinct type 2 inflammatory disease, the cellular and molecular events that drive disease pathogenesis remain poorly understood. This is due in part to the absence of robust and physiologically relevant experimental models that recapitulate human disease METHODS: Experimental EoG was induced in wild-type and Il13ra1 mice by repeated intragastric oxazolone challenges in skin-sensitized mice. IL-4Rα was neutralized using antibodies. Gastric histopathology was determined by H&E, anti-Ki67, chloroacetate esterase, and anti-MBP staining. Gastric RNA was subjected to RNA sequencing. - Source: PubMed
Publication date: 2026/06/18
Dsilva AnishSharma ShraddhaBarakey ShireenWagner ArielKeisar AliceBar-On TaliItan MichalMunitz Ariel