Human CEACAM6 _CD66c Protein Vector: HEK294
- Known as:
- Human CEACAM6 _CD66c Protein Vector: HEK294
- Catalog number:
- 10012-H01H
- Product Quantity:
- 100μg
- Category:
- -
- Supplier:
- Provo
- Gene target:
- Human CEACAM6 _CD66c Protein Vector: HEK294
Related genes to: Human CEACAM6 _CD66c Protein Vector: HEK294
- Gene:
- CEACAM6 NIH gene
- Name:
- carcinoembryonic antigen related cell adhesion molecule 6
- Previous symbol:
- NCA
- Synonyms:
- CD66c
- Chromosome:
- 19q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-30
- Date modifiied:
- 2016-10-05
Related products to: Human CEACAM6 _CD66c Protein Vector: HEK294
Related articles to: Human CEACAM6 _CD66c Protein Vector: HEK294
- Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is a glycophosphatidylinositol-anchored member of the immunoglobulin superfamily, often overexpressed in various malignancies. Targeting CEACAM6 by suppressing its expression can potentially reverse these effects, making it a promising therapeutic target. In this study, we generated five monoclonal antibodies (CEAS1, CEAS2, CEAS3, CEAS4, and CEAS5; CEAS1-S5) against the recombinant CEACAM6 protein. - Source: PubMed
Publication date: 2025/06/17
Wang Yun-HsinChen Yau-Hung - Fibromyalgia syndrome (FM) is a chronic pain disorder affecting 3-6 % of the global population, often underdiagnosed and lacking specific diagnostic tests. Many patients also present with dry eye disease (DED), suggesting a possible link. This study explores the relationship between DED and FM-associated DED (FM-DED) by evaluating corneal nerve abnormalities using in vivo corneal confocal microscopy (IVCM), alongside gene expression and polymorphisms (COMT, MTHFR) related to inflammation. - Source: PubMed
Publication date: 2025/10/31
Vergés CarlosGiménez-Capitán AnaRibas VerónicaMartínez-Pérez ElizabethGonzález María JoséMarch de Ribot FrancescArmiger-Borras NoeliaCaycedo AndreaRodríguez-Muñoz CristinaAlegre CayetanoMuñoz SusanaSalgado-Borges JoséMayo-de-Las-Casas Clara - Adherent-invasive (AIEC) associated with Crohn's disease (CD) are traditionally defined by the adherence and invasion of epithelial cells and survival in macrophages. However, their interactions with differentiated intestinal epithelia remain largely unexplored. Here, we investigated the pathogenesis of AIEC prototype strain LF82 in polarized human colon carcinoma cells and colonic organoids. While LF82 infection of Caco-2 and T84 cells was characterized by CEACAM6-independent adherence, biofilm formation, inflammation, and contact-mediated cytotoxicity, invasion was comparably low to that of noninvasive MG1655. An investigation of additional AIEC isolates revealed that biofilm production and cell damage were specific for strain LF82. Infection of human colonoids confirmed biofilm formation, negligible invasion, and cytotoxicity of AIEC LF82. However, bacteria adhered preferentially to the mucus layer and penetrated to the epithelial surface. Our results suggest that LF82 pathogenesis in the human colon is characterized by the formation of adherent biofilms, mucus penetration, and contact-dependent cytotoxicity, which likely contributes to epithelial leakage and inflammation in CD. - Source: PubMed
Publication date: 2025/10/29
Evans Bethan FayDorji TsheringBigaliyeva DamiraChan SimonSchüller Stephanie - Pancreatic ductal adenocarcinoma is among the most lethal malignancies, underscoring the urgent need for a deepened molecular insights and targeted strategies. While microRNAs (miRNAs) are known to regulate key oncogenic pathways in PDAC, most studies overlook the functional heterogeneity between the 3p and 5p strands derived from the same miRNA precursor. Here, we systematically investigate the strand-specific roles of miR-301a-3p and miR-301a-5p in PDAC progression. Using a multidimensional approach, including clinical tissue-based FISH, serum analysis, cell-based assays, and xenograft models, we revealed a consistent pattern of miR-301a-3p upregulation and miR-301a-5p downregulation in PDAC tissues and fluids. Importantly, the ratio of 5p to 3p is negatively correlated with TNM stage, and its combination with CA19-9 significantly improves prognostic prediction. Mechanically, the two strands exert opposing effects on tumor progression via distinct cell death pathways. miR-301a-3p promotes tumorigenesis by targeting ACSL4 to suppress ferroptosis, while miR-301a-5p induces pyroptosis by activating NF-κB pathway through CEACAM6-TNFR1 axis. These findings challenge the prevailing "dominant strand" paradigm and uncover a previously unrecognized antagonism between miRNA strands. By highlighting the risks of indiscriminate miRNA targeting, our work supports the development of strand-specific diagnostic and therapeutic strategies in PDAC. This study advances the concept of chain-level regulation as a foundation for precision oncology. - Source: PubMed
Publication date: 2025/10/28
Chen YuhangDai SuoyiCai WenxunZhao JiangangZhang FenglinCheng Chien-ShanChen Lianyu - Colorectal cancer (CRC) is a leading causes of cancer-related mortality worldwide. Dysregulated expression of specific genes and non-coding RNAs contributes to CRC progression. This study investigated the expression and clinical relevance of CEACAM6, HOXA-AS3, and miR-29a in CRC, combining experimental data with bioinformatics analysis to assess their diagnostic and prognostic value. Tissue samples from 68 CRC patients (tumor and adjacent normal) were analyzed for CEACAM6, HOXA-AS3, and miR-29a expression by real-time PCR. Bioinformatics validation using TCGA, GEPIA, and ENCORI databases assessed expression, interactions, and assess clinical associations. CEACAM6 and miR-29a were significantly upregulated, while HOXA-AS3 was downregulated in CRC tissues compared to normal counterparts. Notably, miR-29a also showed elevated expression levels in patient serum samples (p < 0.05). Among the examined markers, CEACAM6 expression varied significantly with tumor differentiation status (p < 0.05). Serum levels of IL-6 were significantly increased in CRC patients (p < 0.05). Receiver operating characteristic (ROC) analysis demonstrated high diagnostic accuracy for miR-29a (AUC = 0.918). A significant positive correlation was observed between miR-29a expression in serum and tumor tissue (p = 0.038). Additionally, in silico analysis suggested regulatory interactions between HOXA-AS3 and the mRNAs of CEACAM6 and IL-6. CEACAM6, HOXA-AS3, and miR-29a may serve as promising biomarkers for early detection and prognosis of CRC. Integrating molecular profiling with bioinformatics validation provides a robust approach to uncover clinically relevant targets in CRC. The correlation between serum and tumor tissue miR-29a expression highlights its potential utility in liquid biopsy approaches for CRC. - Source: PubMed
Publication date: 2025/10/24
Bahramian ShabbouAkbar SoroushNikoo Mohammad Hadi RazaviAmini AbolfazlShamsabadi Fatemeh Tash