Human CEACAM8 _CD66b Protein Vector: HEK294
- Known as:
- Human CEACAM8 _CD66b Protein Vector: HEK294
- Catalog number:
- 10010-H01H
- Product Quantity:
- 100μg
- Category:
- -
- Supplier:
- Provo
- Gene target:
- Human CEACAM8 _CD66b Protein Vector: HEK294
Related genes to: Human CEACAM8 _CD66b Protein Vector: HEK294
- Gene:
- CEACAM8 NIH gene
- Name:
- carcinoembryonic antigen related cell adhesion molecule 8
- Previous symbol:
- CGM6
- Synonyms:
- CD66b
- Chromosome:
- 19q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1991-09-12
- Date modifiied:
- 2016-01-14
Related products to: Human CEACAM8 _CD66b Protein Vector: HEK294
Related articles to: Human CEACAM8 _CD66b Protein Vector: HEK294
- Lung adenocarcinoma (LUAD) sustains an immunosuppressive tumor microenvironment (TME) via stromal-immune interactions. Efferocytosis regulates immune suppression and tissue homeostasis, yet biomarkers stratifying its TME states are lacking in LUAD, hindering precision therapy. This study aimed to investigate efferocytosis-associated immune regulation with both causal and prognostic relevance in LUAD, and to identify key biomarkers with potential implications for tumor stratification and therapeutic guidance. - Source: PubMed
Publication date: 2025/09/28
Xing ZheruiLiu YuanxinYang XueYao YangChang TaoZhou LaiyanLuo RenJiang LiliXue Jianxin - Obesity represents a significant public health challenge on a global scale. Bariatric surgery is an effective intervention for individuals with severe obesity, leading to the amelioration or resolution of numerous obesity-related comorbidities with improved quality of life. Numerous studies have demonstrated that bariatric surgery is more effective than medical weight management interventions for remission of type 2 diabetes (T2D) among patients with obesity; however, there is heterogeneity of response in this regard. In the current analysis, we examined critical differentially expressed genes (DEGs) in patients with obesity and T2D who had remission versus non-remission after bariatric surgery, i.e., responders versus non-responders. We downloaded the gene expression profile GSE271700 from the Gene Expression Omnibus and preprocessed it with GEO2R. 73 differential expressed genes with │ LFC │ > 1 and p value < 0.05 have been recognized in the responder group which were examined in subsequent analyses. SRSF5, MAGOH, LTF, NUP153, CAMP, CEACAM8, and HBD are identified as hub genes using cytoHubba plugin in cytoscape. Moreover, CAMP, CEACAM8, HBD, and LTF were shared between hub genes and the best module (identified using the MCODE plugin). ZBTB33, TAF1, and BCLAF1 were recognized as the most significant transcription factors, and CSNK2A1, CDK1, and MAPK14 were found as the most significant kinases. Moreover, functional analysis showed that DEGs affect mRNA processing and mRNA surveillance pathways. Innate immune response and regulation of cellular response to heat were the best results of biological processes. These results could help to better understand the differences in diabetes remission among patients with obesity. - Source: PubMed
Publication date: 2025/09/24
Mahjoubin-Tehran MaryamTalebloo JonanneGadde Kishore MSukhorukov Vasily NJamialahmadi TannazSahebkar Amirhossein - Myasthenia gravis (MG) presents significant health and economic challenges. To identify novel biomarkers, we analyzed proteomic data from 52,704 UK Biobank individuals, focusing on 1463 baseline proteins with follow-up >10 years. Baseline and potential MG cases were 1:5 matched to controls by using propensity score matching. We identified 38 consistently up-regulated differentially expressed proteins (DEPs) in both the baseline and potential MG groups compared to controls, categorized into cardiometabolic, inflammation, neurology, and oncology panels. These DEPs showed potential diagnostic value for distinguishing MG from other neuromuscular disorders, with the area under curves ranging from 0.616 to 0.735 across three models (logistic regression, support vector machine, and random forest). To further investigate causality, two-sample Mendelian Randomization (2SMR) and Cox proportional hazard regression were conducted, and we confirmed 18 potential causal proteins associated with MG, including those in the cardiometabolic panel (CEACAM8, OLR1, PGLYRP1, S100A11, and TNC), inflammation panel (CST7, HGF, IL1RN, IL-6, JCHAIN, OSM, PLAUR, and TGFA), neurology panel (CTSS, MMP8, TBC1D17, and VCAN), and oncology panel (S100A12). Currently, no approved drugs for MG specifically target these identified potential causal proteins and ligands. This comprehensive proteomic analysis highlights novel biomarkers associated with MG, suggesting potential targets for identifying risk proteins and future therapeutic interventions. - Source: PubMed
Publication date: 2025/09/08
Chen Hong-XiLin XueZhang Na-NaShi Zi-YanZhang YingDu QinKong Ling-YaoSun Dong-RenWang RuiMou Zi-ChaoZhang Yang-YangMo Yun-TaoWang Xiao-FeiZhou Hong-Yu - The cellular and molecular pathophysiology of urosepsis, a condition caused by a urinary tract infection spreading to the bloodstream, involves complex epigenetic behavior. The objective of this study was to identify relevant genes and signaling pathways in adult urosepsis through a bioinformatic analysis of differentially expressed genes (DEGs). - Source: PubMed
Publication date: 2025/10/08
Shi Xu XiRong Lu RongWei Huang Zhong - This study aimed to compare the density and spatial distribution of tumor-associated neutrophils (TANs) in metaplastic breast cancer (MpBC) and non-metaplastic triple-negative breast cancer (TNBC) patients before neoadjuvant chemotherapy (NACT) to identify prognostic biomarkers and therapeutic implications. - Source: PubMed
Publication date: 2025/09/01
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