Human CEACAM8 _CD66b Protein Vector: HEK294
- Known as:
- Human CEACAM8 _CD66b Protein Vector: HEK294
- Catalog number:
- 10010-H01H
- Product Quantity:
- 100μg
- Category:
- -
- Supplier:
- Provo
- Gene target:
- Human CEACAM8 _CD66b Protein Vector: HEK294
Related genes to: Human CEACAM8 _CD66b Protein Vector: HEK294
- Gene:
- CEACAM8 NIH gene
- Name:
- carcinoembryonic antigen related cell adhesion molecule 8
- Previous symbol:
- CGM6
- Synonyms:
- CD66b
- Chromosome:
- 19q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1991-09-12
- Date modifiied:
- 2016-01-14
Related products to: Human CEACAM8 _CD66b Protein Vector: HEK294
Related articles to: Human CEACAM8 _CD66b Protein Vector: HEK294
- Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma in the world. It exhibits high heterogeneity and invasiveness and is prone to developing treatment resistance. Therefore, there is an urgent need for good prognostic evaluation indicators and therapeutic targets. In recent years, immunotherapy has become a research hotspot for DLBCL. Tumor-associated neutrophil (TAN) is widely expressed in various tumors and is an important component of the immune microenvironment. However, there have been few studies on the role of TAN in DLBCL. This study has demonstrated that CD66b, which is a marker of TAN, is a good prognostic marker of DLBCL and its expression is related to the prognosis of DLBCL patients. The expression level of CD66b is also closely correlated with the objective response rate of the R-CHOP treatment regimen in DLBCL patients with non-GCB subtype. The expression level of CD66b has a high reference value for the determination of the treatment plan. The combined detection of CD66b and PD-L1/PD-L2 is of significance to predict the prognosis of DLBCL patients. - Source: PubMed
Tao YunWu YaxunZhang XingsongHe SongMiao Xiaobing - This study aimed to evaluate the prognostic utility of serum carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) and CEACAM8 levels in children with Mycoplasma pneumoniae pneumonia (MPP). This single-center prospective cohort study enrolled 364 children with confirmed MPP and 160 age-matched healthy controls between February 2023 and May 2025. Serum levels of CEACAM6, CEACAM8, lactate dehydrogenase (LDH), D-dimer, interleukin-6, C-reactive protein, and myeloperoxidase were measured at admission using enzyme-linked immunosorbent assay. Patients were classified into good- (n = 295) or poor-prognosis (n = 69) groups after 1 week of standardized azithromycin therapy based on clinical, radiological, and spirometric criteria. Multivariable logistic regression was used to identify independent predictors of poor outcome. Receiver-operating characteristic curve analysis assessed the predictive performance of CEACAM6 and CEACAM8, individually and in combination, with corresponding areas under the curve. Correlations with inflammatory markers were evaluated using the Spearman rank correlation test. Children with poor outcomes had significantly higher CEACAM6 and CEACAM8 levels at admission (both P < .001). Multivariable analysis identified elevated CEACAM6 (odds ratio = 1.12, 95% confidence interval = 1.05-1.19) and CEACAM8 (odds ratio = 1.09, 95% confidence interval = 1.03-1.15) as independent predictors of poor prognosis. Receiver-operating characteristic analysis demonstrated areas under the curve of 0.771 for CEACAM6, 0.755 for CEACAM8, and 0.826 for their combination. Both biomarkers correlated positively with interleukin-6, C-reactive protein, and myeloperoxidase (all P < .01) and declined significantly after treatment. Serum CEACAM6 and CEACAM8 are independently associated with poor outcomes in pediatric MPP. Their combined use enhances prognostic accuracy and may support early risk stratification in clinical practice. - Source: PubMed
Ge ShenghuaMa LingyanSong Dongqing - Neutrophils are the most abundant granulocytes in the tumor microenvironment and exert both pro- and anti-cancer effects. Activated neutrophils can release neutrophil extracellular traps (NETs) that have been proposed to promote tumor progression and metastasis. We aimed to clarify the significance of NETs and granulocytes in colorectal cancer. - Source: PubMed
Publication date: 2026/04/07
Rahkola OskariTuomisto AnneElomaa HannaKarjalainen HennaÄijälä Ville KKastinen MeeriTapiainen Vilja VKehusmaa AkseliOjanperä AinoPohjanen Vesa-MattiAhtiainen MaaritHelminen OlliWirta Erkki-VilleRintala JukkaMeriläinen SannaAro RailaHäivälä ReettaSaarnio JuhaRautio TeroSeppälä Toni TBöhm JanMecklin Jukka-PekkaMäkinen Markus JVäyrynen Juha PSirniö Päivi - Transcriptomic analysis of blood cells can reveal key elements of the dysregulated host response in sepsis and spur biomarker and mechanism identification. We hypothesized that sepsis nonsurvivors exhibit a distinct transcriptional signature in whole blood that reflects insights to sepsis mortality. We conducted a prospective observational cohort study of 161 critically ill sepsis patients. Whole blood RNA was collected within 24 hours of intensive care unit admission. Gene expression levels were measured using microarrays and changes in gene levels were compared between 30-day nonsurvivors and survivors, adjusting for age, sex, and neutrophil count. Pathway overrepresentation analysis and weighted gene co-expression analysis were performed to identify biological pathways and gene co-expression groups, respectively, associated with sepsis mortality. Gene- and pathway-based results were compared to findings in an independent cohort of 479 sepsis patients with 28-day mortality data. Thirty-day mortality in the enrolled sepsis cohort was 37% (60 of 161 patients). We identified 1,106 differentially expressed genes in nonsurvivors (Benjamini-Hochberg-adjusted p-value <0.05), including several neutrophil-related genes (CEACAM8, ELANE, PRTN3, MPO, CEACAM6, DEFA4, MS4A3) with expression levels over 1.8 times higher in nonsurvivors despite adjusting for neutrophil counts. The neutrophil degranulation pathway was prominent based on its overrepresentation in 1) differentially expressed genes in both cohorts, 2) overrepresentation by gene set enrichment analysis, and 3) four of the six gene co-expression groups correlated with sepsis mortality. Our findings highlight the involvement of neutrophil degranulation genes in sepsis mortality, prompting further study to better understand whether they constitute a modifiable target. - Source: PubMed
Publication date: 2026/02/21
Giannini Heather MKan MengyuanCosgriff Christopher VMorley Michael PMiano Todd ANarayanan NishaIttner Caroline A GTurner Alexandra PEsperanza Mika PErlich Matthew COniyide OluwatosinAnderson Brian JJones Tiffanie KFeng RuiReilly John PHimes Blanca EShashaty Michael G SMeyer Nuala J - Gastric cancer (GC) is the fifth most common type worldwide, representing a public health problem. Among the genes related to this tumorigenesis, the family of matrix metalloproteinases (MMPs), essential regulators of the extracellular matrix (ECM), stand out for their involvement in the development and progression of GC. Therefore, we aimed to evaluate MMP gene expression variation, its relationship with clinicopathological factors and its transcriptome-wide associations. To this end, RNAseq, correlation network, and biological pathway enrichment analyses were performed on tumor samples from GC and peritumoral samples from patients treated at a reference center in the Northern region of Brazil. Among the 22 investigated MMPs, seven genes (MMP2, MMP3, MMP10, MMP12, MMP14, MMP15, and MMP16) were upregulated in cancer, while MMP8 was downregulated. Increased expression of seven of the eight differentially expressed MMPs was found in early stages of the disease compared to Tumor, Node, Metastasis (TNM) stage IV. MMP16 showed higher expression in the diffuse-type gastric adenocarcinoma. An increased expression of MMP10 was observed in the EBV/TCGA group. A significant reduction in survival was noticed in those patients with lower expression of MMP8, MMP12, and MMP14. Transcriptomic correlation analyses demonstrated that differentially expressed MMPs interact with genes likely involved in cell adhesion, ECM organization, and immune response, such as COL1A2, CDH11, KIRREL1, PPP1R14D, CEACAM8, ZNF423, and PRRX1. The enrichment of biological pathways suggests involvement in processes such as ECM organization, collagen and proteoglycan degradation, suggesting that these genes possibly are involved in carcinogenic dynamics, supporting the role of MMPs in tumor ECM reorganization. - Source: PubMed
Publication date: 2026/02/23
Bastos Aline CostaKhayat André SalimMoraes Emanuele Raimunda LouzadaTavares Ágatha Tereza MirandaMourão Ronald Matheus da SilvaMoreira Fabiano CordeiroCasseb Samir Mansour MoraesDemachki SamiaIshak GeraldoBarra Williams FernandesBurbano Rommel Mario Rodríguezde Assumpção Paulo Pimentel