IGSF11 antibody
- Known as:
- IGSF11 (anti-)
- Catalog number:
- orb1928
- Product Quantity:
- 100ug
- Category:
- -
- Supplier:
- Biorb
- Gene target:
- IGSF11 antibody
Related genes to: IGSF11 antibody
- Gene:
- IGSF11 NIH gene
- Name:
- immunoglobulin superfamily member 11
- Previous symbol:
- -
- Synonyms:
- BT-IgSF, MGC35227, Igsf13, VSIG3, CT119
- Chromosome:
- 3q13.32
- Locus Type:
- gene with protein product
- Date approved:
- 2002-12-04
- Date modifiied:
- 2016-10-05
Related products to: IGSF11 antibody
Related articles to: IGSF11 antibody
- Most pregnancies are affected by nausea and vomiting, but the most severe form-hyperemesis gravidarum-can be life threatening. Here we performed a multi-ancestry genome-wide association study of hyperemesis gravidarum in 10,974 cases and 461,461 controls across European, Asian, African and Latino ancestries. We identified ten associations: four identified previously (GDF15, IGFBP7, PGR and GFRAL) and six additional loci (SLITRK1, SYN3, IGSF11, FSHB, TCF7L2 and CDH9). Downstream analyses revealed GDF15 and TCF7L2 expression primarily in extravillous trophoblasts, with opposing effects for GDF15 between maternal and fetal genotype. Conversely, IGFBP7 and PGR were expressed primarily in maternal spiral arteries, with effects limited to the maternal genome. Selected loci were associated with abnormal pregnancy weight gain, duration, birth weight and pre-eclampsia. Functional studies identified additional associations including antisense IGFBP7-AS1 and protein ACP1. Potential roles for candidate genes in appetite, insulin signaling and brain plasticity provide pathways to explore etiological mechanisms and therapeutic avenues. - Source: PubMed
Publication date: 2026/04/14
Fejzo MarlenaWang XinranTan QingZöllner JuliaPujol-Gualdo NatàliaLaisk Triin Finer Sarahvan Heel David A Brumpton BenBhatta LaxmiHveem KristianJasper Elizabeth AVelez Edwards Digna RHellwege Jacklyn NEdwards ToddJarvik Gail PLuo YuanKhan AtlasMacGibbon KimberGao YuanGe GaoxiangAverbukh InnaSoon ErinAngelo MichaelMagnus PerJohansson StefanNjølstad Pål RKim ArtemGazal StevenVaudel MarcShu Chang AprilMancuso Nicholas - Diffuse midline glioma (DMG) is an aggressive pediatric brain tumor with no curative treatment, and lacks a comprehensive understanding of immune-tumor cell interactions within their spatial context. Our multi-omics approach, integrating single-nuclei RNA sequencing, spatial transcriptomics, and high-dimensional imaging, utilizes patient samples and an experimental murine DMG model to unveil two spatially distinct regions. MES-patterns are defined by mesenchymal (MES) tumor cells and blood-derived immune cells, whereas AOO-patterns are enriched with astrocyte (AC)-, oligodendrocyte (OC)-, and oligodendrocyte precursor cell (OPC)-like cancer populations, alongside homeostatic-like microglia. The less-studied immune checkpoint, IGSF11, is primarily expressed by AOO-associated cancer cells, while its receptor VISTA is detected mainly in homeostatic microglia. Targeting IGSF11-VISTA results in tumor reduction and survival benefit, mediated by brain-resident microglia and independent of T cell infiltration. This positions IGSF11-VISTA as a promising immune checkpoint treatment axis to harness the local brain immune response against DMG. - Source: PubMed
Publication date: 2026/01/22
Collot RaphaëlRuiz-Moreno CristianHonhoff Celinavan den Broek Thijs J MWezenaar Amber K LKloosterman Daan JAriese Hendrikus C RJohnson HannahVervoort Britt M TJeiroshi AmalBunt Jensvan Ineveld Ravian LBokobza EmmaRebel Heggert GTe Pas Brigit MRingnalda Femke C Avan de Wetering MarcRobe Pierre AKool MarcelCochran Jennifer RKranendonk Mariëtte E Gvan Vuurden Dannis GHulleman EstherWehrens Ellen JZomer AnoekStunnenberg Hendrik GRios Anne C - Dogs display temperamental and behavioral variation between individuals, just as psychiatric, temperamental, and cognitive traits vary in humans. In both species, these traits are highly heritable, yet causal genes remain incompletely understood. We performed 14 genome-wide association studies (GWAS) for behavioral traits quantified using the Canine Behavioral Assessment and Research Questionnaire (C-BARQ) in ~1,000 golden retrievers, identifying 12 genome-wide significant loci ( < 2.97 × 10) for 8 traits and 9 additional loci exceeding a suggestive threshold ( < 1 × 10). A human phenome-wide association study (PheWAS) showed that most of the 18 canine positional candidate genes identified were associated with one or more of 190 psychiatric, temperamental, or cognitive traits in humans (7/12 genes at genome-wide loci and 5/9 at suggestive loci). For example, a genome-wide significant locus near (dog-directed aggression) overlapped with human measures of Intelligence, Educational attainment, and major depressive disorder. The gene was within a genome-wide significant locus for trainability in dogs and associated with intelligence, depression, irritability, and sensitivity/hurt feelings in humans. Other genes located at genome-wide significant loci associated with behavioral, psychiatric, temperamental, or cognitive traits in both species included (touch sensitivity) and (trainability), and (stranger-directed fear). From suggestive loci we also found cross-species associations for (dog-directed fear), and (separation-related problems). These results suggest that shared genetic and molecular mechanisms underlie complex behavioral and temperamental states across species and may inform our understanding of emotional states driving undesirable behaviors in dogs. - Source: PubMed
Publication date: 2025/11/24
Alex EnochGennotte PaulMorros Nuevo AnnaYu YunzhuKeep BenjaminSullivan MeganMills DanielWarrier VarunRaffan Eleanor - The Danioninae subfamily of teleost fishes boasts up to four hundred distinct species that have evolved to display a stunning diversity of morphological forms. Here we use newly assembled genome sequences of four laboratory and wild zebrafish strains as well as eleven species of the and genera to explore their phylogenetic history and the genetic basis of pigment pattern diversification. Phylogenomic analyses uncover extensive introgression and incomplete lineage sorting that have obscured phylogenetic relationships within and corroborate an ancient hybrid origin of zebrafish. Whereas inherited ancestral horizontal stripes, relatives repeatedly evolved spots and vertical bars. Interspecific complementation tests reveal functional divergence of the adhesion molecule gene and the gap junction gene between the striped zebrafish and species with divergent patterns. Comparative genomic and transcriptomic analyses suggest that protein and regulatory evolution have accompanied pigment pattern diversification. Our analyses elucidate complex genetic changes underlying the phylogenetic history and morphological diversification in the genus. Resolved phylogenetic relationships, available genome assemblies, transcriptomes, and genetic tractability establish fish species as excellent models for biomedical research in vertebrates. - Source: PubMed
Publication date: 2025/10/18
Lu JianguoPodobnik MarcoHuang JunrouMcCluskey Braedan MMcCarthy Shane AWood JonathanCollins JoannaTorrance JamesSims YingGao DongHuang JingLiu JiaFang WenyuHuang PeilinMa ChunleiParichy DavidIrion UweLiu JianHowe KerstinPostlethwait John H - Immunoglobulin superfamily member 11 (IGSF11) has recently emerged as a critical immune checkpoint ligand that interacts with the V-domain immunoglobulin suppressor of T-cell activation (VISTA) receptor to inhibit T-cell activation and promote immune escape. Preclinical studies have demonstrated that targeting the IGSF11-VISTA axis effectively reverses immunosuppression by enhancing T-cell effector functions and increasing the secretion of prostimulatory cytokines such as IFN-γ. This immune modulation shifts the tumor microenvironment from an immune "cold" state, characterized by low immune infiltration and activity, to a more immunoreactive "hot" state that is more susceptible to immune-mediated destruction. Moreover, combining IGSF11 inhibition with established therapies such as anti-PD-1/PD-L1 improves treatment efficacy in various cancer models. In this review, we focus on the immunomodulatory functions of IGSF11, its role in combination immunotherapies, and preclinical evidence supporting its potential as a novel therapeutic target to overcome resistance and improve cancer immunotherapy outcomes. - Source: PubMed
Publication date: 2025/08/13
Srivastava SapnaKartikasari Apriliana E RTelukutla Srinivasa ReddyPlebanski MagdalenaBanerjee Dibyendu