Slc22a5 antibody (FITC)
- Known as:
- Slc22a5 (anti-) (fluorecein)
- Catalog number:
- orb4977
- Product Quantity:
- 100ug
- Category:
- -
- Supplier:
- Biorb
- Gene target:
- Slc22a5 antibody (FITC)
Related genes to: Slc22a5 antibody (FITC)
- Gene:
- SLC22A5 NIH gene
- Name:
- solute carrier family 22 member 5
- Previous symbol:
- CDSP
- Synonyms:
- OCTN2, SCD
- Chromosome:
- 5q31.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-07-16
- Date modifiied:
- 2016-10-05
Related products to: Slc22a5 antibody (FITC)
Related articles to: Slc22a5 antibody (FITC)
- Triple-negative breast cancer (TNBC) remains one of the most clinically challenging malignancies, characterized by aggressive behavior, high metastatic propensity, and limited therapeutic options. Conventional chemotherapy and immunotherapy have demonstrated only partial efficacy, underscoring the urgent need for novel precision oncology strategies. Radionuclide therapy, including targeted radioligand therapy and theranostic approaches, has emerged as a transformative modality in precision oncology, yet its application in TNBC is constrained by an incomplete understanding of molecular targets and tumor microenvironment heterogeneity. Single-cell RNA sequencing (scRNA-seq) provides unprecedented resolution for characterizing gene expression profiles and cellular heterogeneity within the TNBC ecosystem. - Source: PubMed
Publication date: 2026/06/23
Xing XiaoxiaoYu HuihuanZhang Songliang - Plumage color is an economically important trait in chickens, and barred chickens are characterized by a distinct feather pattern in which variation in pigmentation (yellow-barred vs. white-barred) is frequently observed. Although the genetic basis of barred patterning has been partially elucidated, the mechanisms underlying pigmentation differences within barred feathers remain unclear. In this study, genome-wide association study (GWAS) and selection signature (F) analyses based on 47 individuals (20 yellow-barred and 27 white-barred) identified several candidate genomic regions and genes, including BRINP2, SLC22A4, SLC22A5, and ACTN1, potentially associated with pigment variation. Transcriptomic analysis of feather follicles further revealed substantial gene expression divergence between the two phenotypes, with 739 differentially expressed genes identified, among which SLC45A2, BCO2, EDAR, KRT75, and KRT14 were notable candidates. Functional enrichment analysis indicated that these genes are primarily involved in skin development, epidermal differentiation, keratinization, and intermediate filament organization. Integrated analyses suggest that coordinated regulation of melanin synthesis, carotenoid metabolism, and feather follicle structural development contributes to the observed pigmentation differences. Overall, this study provides genomic and transcriptomic insights into the molecular basis of pigmentation variation in barred chickens and offers a foundation for future functional validation and molecular breeding. - Source: PubMed
Publication date: 2026/06/10
Chen TairanRen XufangZuo DengjingZhao XiurongChen AnqiLi FuguiZhang XinyeJiang XiaoyuYu HongxiQu Lujiang - Role of Vitamin D Receptor (VDR), Calcium Sensing Receptor (CaSR) and their associated long non-coding RNAs (lncRNAs) in Parathyroid Cancer (PC) development and PC diagnosis need to be explored. LncRNA SLC2A1-DT and SLC22A5-AS1 were dysregulated in previous microarray study. LncRNA SLC2A1-DT may target on VDR in prediction. Meanwhile, lncRNA SLC22A5-AS1was associated with CaSR. - Source: PubMed
Publication date: 2026/06/18
Zhang DongxueZhao TengBi DehuiHuang JianJiang TaoZhao PengxiangWei Bojun - Carrier screening is a long-standing genetic testing process offered to at-risk couples, with or without a family history, who might have pregnancies affected by an autosomal recessive (AR) or X-linked (XL) disorder. A total of 276 unrelated individuals, initially referred for rare disorder screening by clinicians, were enrolled in this study and tested by Exome sequencing (ES). Expanded carrier screening (ECS) was performed for 176 disorders that met the inclusion criteria of the ACMG and ACOG. Genes with single nucleotide variants (SNVs) identified with a carrier rate > 1% for AR disorders included HBB, CFTR, PMM2, NPHS2, GJB2, ACADM, ALDOB, MEFV, MKS1, NEB, PAH, ATM, CPT2, CYP21A2, AGXT, BBS1, CAPN3, COL4A4, DHCR7, GAA, IVD, LAMA2, SLC22A5, SLC26A4, USH2A. For XL disorders, variants were detected in the RS1 gene. ECS offers a wealth of information about SNVs related to AR and XL disorders in specified populations. The information obtained from ECS provides multiple advantages: (a) it identifies the most prominent risks in health care in a given population and contributes to the prevention of genetic disorders, (b) it enriches available databases with pathogenic or likely pathogenic SNVs, and (c) it records novel targets for molecular clinical genetic testing. - Source: PubMed
Publication date: 2026/05/29
Kostoulas CharilaosSesse AthanasiaBouba IoannaNajdecki RobertKonitsiotis SpyridonMarkoula SofiaGeorgiou Ioannis - Gastric cancer (GC) poses a significant health threat, and alterations in Fatty acid β-oxidation (FAO) may influence its progression. However, the precise mechanisms underlying this association remain unclear. FAO-related genes were analyzed using transcriptomic datasets from databases of GEO and TCGA. Totally 160 FAO-associated genes were identified, and a risk scoring model was subsequently established to stratify patients into groups of low- and high-risk. Immune characteristics, drug sensitivities, and hub genes, including IL-6, were assessed. Subsequently, immunoblotting and immunohistochemistry were performed on GC cell lines and tissue samples to evaluate IL-6 expression. Analysis of the TCGA and GEO databases revealed a FAO-related gene signature comprising ACADS, ACO2, CPT2, SLC22A5, AOC3, CD36, CIDEA, G0S2, GABARAPL1, and SERINC1. We also examined gene mutations and constructed a prognostic risk scoring model with validation achieved through a nomogram to predict gastric cancer risk. Immune infiltration analysis and drug sensitivity testing (e.g. AG-014699, Axitinib, BX-795, and Cisplatin) were also conducted. IL-6 emerged as a core gene with significant expression difference across cellular and tissue levels. FAO plays a critical role in the prognosis of GC, and IL-6 may serve as a key biomarker for diagnosis and therapeutic strategies. - Source: PubMed
Publication date: 2026/05/02
Qu ChaoYuan XuetaoYang ShutingQiao YifanZhang RenjianzhiWu YunhuaZhu MengkeDu JiayinLi GanZhang RuiSun XuejunLi Xuqi