Slc22a5 antibody (FITC)
- Known as:
- Slc22a5 (anti-) (fluorecein)
- Catalog number:
- orb4977
- Product Quantity:
- 100ug
- Category:
- -
- Supplier:
- Biorb
- Gene target:
- Slc22a5 antibody (FITC)
Related genes to: Slc22a5 antibody (FITC)
- Gene:
- SLC22A5 NIH gene
- Name:
- solute carrier family 22 member 5
- Previous symbol:
- CDSP
- Synonyms:
- OCTN2, SCD
- Chromosome:
- 5q31.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-07-16
- Date modifiied:
- 2016-10-05
Related products to: Slc22a5 antibody (FITC)
Related articles to: Slc22a5 antibody (FITC)
- Diabetic retinopathy (DR) is often recognized as a marker of systemic microvascular disease, but the metabolic links to other complications, such as diabetic nephropathy (DN), remain unclear. We aimed to identify systemic metabolic signatures shared by DR and DN and investigate their potential causal mechanisms. - Source: PubMed
Liu QianLiu YanYang XiongyiLiu TianyiZhao YaXia JiaoFu XueyunYao MudiWang YufanJiang QinYan Biao - Organic cation transporters novel 1 and 2 (OCTN1/2) localize specifically to the brush border membrane of human placentas, where they facilitate transmembrane delivery of vital substrates including ergothioneine and l-carnitine to sustain placental antioxidant balance and fetal energy metabolism. Multidrug regimens are frequently administered to manage gestational complications, yet these therapeutics may unintentionally impair placental OCTN1/2 activity and perturb bidirectional maternal-fetal nutrient trafficking. Herein, we established and fully validated a human placental brush border membrane vesicle (BBMV) model. Morphological and biochemical characterization confirmed structural integrity, high purity, and a predominantly right-side-out orientation (ROV), with stable OCTN1/2 expression. Substrate uptake experiments with ergothioneine and l-carnitine revealed classical saturable concentration-dependent kinetics, which were substantially suppressed by verapamil. This validated BBMV model was applied to assess the modulatory actions of 11 widely prescribed antenatal medicines on OCTN1/2 transport function. Most antidiabetic, antihypertensive, and tocolytic drugs exhibited minimal impact on OCTN1. However, metformin, glibenclamide, and labetalol moderately inhibited OCTN2, which could hinder placental l-carnitine uptake. Notably, fluoxetine exerted inhibitory effects on both OCTN1 and OCTN2, implying elevated risks of impaired placental antioxidant defense and energy substrate transfer. These findings elucidate the transport characteristics of placental OCTN1/2 and identify unintended inhibitory effects of common antenatal drugs, providing critical experimental references for rational clinical medication during pregnancy. - Source: PubMed
Publication date: 2026/09/12
Qi QifanLiang ChenmeiziYao BingyiZhao LupingXu XinZhang YuanjinHuang JunzeLiu LeiShen YanWang Xin - Dysregulated lipid metabolism contributes to hepatocellular carcinoma (HCC) progression, but the prognostic value and mechanistic roles of lipid metabolism-related long noncoding RNAs (LRLs) remain insufficiently characterized. This study aimed to construct and validate an LRL-based prognostic model and to investigate the biological function and metabolic mechanism of in HCC. - Source: PubMed
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Liu LixinFan YuhaoZou HaoHu ShengLong KuiLi LianghuaXia ChaoshengWang HongyueLiu YangFeng RunlinDeng ZongqiKang Qiang - To investigate the incidence, genetic mutation characteristics, and prognosis of fatty acid oxidation disorder (FAOD) in neonates in Qingdao. - Source: PubMed
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