SDF-1a (Human) recombinant proteins
- Known as:
- SDF-1a (Human) Rec. proteins
- Catalog number:
- rAP-0060-2
- Product Quantity:
- 2.00 ug
- Category:
- -
- Supplier:
- AngoiPro
- Gene target:
- SDF-1a (Human) recombinant proteins
Related products to: SDF-1a (Human) recombinant proteins
Related articles to: SDF-1a (Human) recombinant proteins
- Successful placentation requires coordinated regulation of trophoblast differentiation, immune tolerance, vascular remodeling, and nutrient transport during the peri-implantation period. The chemokine ligand CXCL12 and its receptor CXCR4 are expressed at the fetal-maternal interface and implicated in trophoblast migration, immune regulation, and angiogenesis, but their in vivo role in early placental functional development remains unclear. The objective of this study was to determine whether suppression of CXCL12/CXCR4 signaling during implantation alters placental programming in sheep. Ewes received intrauterine infusion of CXCR4 antagonist AMD3100 from Day 12-19 of pregnancy, and tissues were collected on Day 20. Pregnancy rates were not affected by treatment; however, pregnancy-associated glycoprotein abundance was increased in treated ewes, indicating altered trophoblast differentiation. Inhibiting CXCR4 reduced expression of angiogenic factors including vascular endothelial growth factor A, placental growth factor, fms-like tyrosine kinase-1, and angiopoietin-1 in endometrium, consistent with impaired vascular development. Suppression of CXCR4 also shifted immune signaling toward a pro-inflammatory profile, with increased interferon-gamma and interleukin-12 and decreased transforming growth factor beta. In addition, expression of glucose and amino acid transporters, including SLC2A1, SLC2A3, SLC38, and SLC7 family members, was altered in fetal membranes and endometrium, accompanied by increased autophagy marker LC3B-II, suggesting metabolic stress. These findings demonstrate that CXCL12/CXCR4 signaling is not required for conceptus attachment but is important for coordinated development of vascular, immune, and metabolic pathways during early placentation. Disruption of this axis produces molecular changes consistent with placental insufficiency, supporting a central role for CXCL12/CXCR4 in establishing functional placental capacity. - Source: PubMed
Publication date: 2026/09/24
Ashley RyanMullins MakaylaSalopek ShaylieSaucedo KylaAlvarez EmaHunt MonetBaez SamanthaKronlein NiklasValdez KassandraButler LaurenRopp Kate - To explore the diagnostic utility of combined CXCR7 and CXCL12 testing in acute myocardial infarction (AMI) and its predictive value for post-percutaneous coronary intervention (PCI) major adverse cardiovascular events (MACE). - Source: PubMed
Pan HongFan XiaoliLiu YuAishan GulijiakelaShao Jingwen - Key features of gastric cancer (GC) include its aggressive nature, high metastatic capability, and a tendency for relapse. While 5-fluorouracil (5-FU) remains a cornerstone of GC treatment, its efficacy is substantially undermined by the emergence of acquired drug resistance. Carnosic acid (CA) has antitumor and immunomodulatory potential, but its role in 5-FU-resistant GC remains unclear. This study investigated whether CA enhances 5-FU sensitivity and CD8 T cell-mediated antitumor immunity by regulating the CXCL12/CXCR7 axis. - Source: PubMed
Publication date: 2026/09/08
Zhang YinanLi DinuoZhang Xin - Leishmania donovani infection causes distinct clinical manifestations, including visceral leishmaniasis (VL) and its dermatological sequel, post-kala-azar dermal leishmaniasis (PKDL), but the mechanisms underlying these divergent phenotypes remain poorly understood. This study investigated the role of skin fibroblasts in regulating THP-1 monocyte responses during VL and PKDL. A fibroblast-monocyte co-culture system was established with patient-derived fibroblasts from healthy controls, VL patients and PKDL patients, in combination with THP-1 monocytes in a Transwell system. The cytokine and chemokine were quantified by real-time PCR and ELISA, and nuclear translocation of NF-κB p50/p65 was determined by western blotting and confocal microscopy. VL fibroblasts potently activated THP-1 cells, resulting in high levels of pro- and anti-inflammatory cytokines (IL-1β, IL-6, TNF-α, IFN-γ, IL-10 and TGF-β) and chemokines (CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL8, CXCL10, CXCL11 and CXCL12). Conversely, PKDL fibroblasts produced a more limited cytokine profile consistent with a regulatory immune environment. Presence of L. donovani significantly attenuated the expression of cytokines and chemokines induced by VL fibroblasts in THP-1 cells, but increased the levels of IL-10 and IL-12 in THP-1 cells co-cultured with PKDL fibroblasts. VL fibroblast conditioned medium induced nuclear translocation of NF-κB p50/p65 in THP-1 cells and this effect was inhibited by IL-6 neutralization. Conversely, exogenous IL-6 addition restored NF-κB activation in THP-1 cells treated with PKDL fibroblast-conditioned medium. These findings highlight that IL-6 produced by skin fibroblasts differentially modulates NF-κB-dependent activation of THP-1 cells in VL as compared to PKDL, underlining the importance of stromal immune interactions in disease-specific immune responses. - Source: PubMed
Publication date: 2026/09/23
Singh SnehaMukherjee RimiDikhit Manas RanjanMadhukar MajorPandey KrishnaSen Abhik - The increasing global ageing population has led to a rising prevalence of elderly atopic dermatitis (eAD). Natural killer (NK) cells play an important role in skin homoeostasis; however, their involvement in eAD remains unclear. This study investigates the functional role and mechanisms of NK cells in eAD pathogenesis. - Source: PubMed
Publication date: 2026/09/22
Fang XiaokaiLi FangGao YuwenZhang YuChen XingyuZhang ShanLuo YangZhou YuanWang ShangshangTian JingruLiu XiaochunLi WeiYao Xu