Recombinant Human TIMP3 Proteins
- Known as:
- Recombinant Human TIMP3 Proteins
- Catalog number:
- RB-15-0001P-50
- Product Quantity:
- 50
- Category:
- -
- Supplier:
- Ray Biotech
- Gene target:
- Recombinant Human TIMP3 Proteins
Related genes to: Recombinant Human TIMP3 Proteins
- Gene:
- TIMP3 NIH gene
- Name:
- TIMP metallopeptidase inhibitor 3
- Previous symbol:
- SFD
- Synonyms:
- -
- Chromosome:
- 22q12.3
- Locus Type:
- gene with protein product
- Date approved:
- 1993-04-12
- Date modifiied:
- 2014-11-19
Related products to: Recombinant Human TIMP3 Proteins
Related articles to: Recombinant Human TIMP3 Proteins
- Identifying novel biomarkers and elucidating the underlying molecular mechanisms are crucial for improving the diagnosis and treatment of advanced clear cell renal cell carcinoma (ccRCC). In our previous investigations, crystallin lambda 1 (CRYL1) was preliminarily identified as an emerging tumor suppressor. The present study expands upon this observation by further exploring its tumor-suppressive role and the underlying molecular mechanisms. - Source: PubMed
Publication date: 2026/05/04
Xu YipengLi PengLiu XigaoZhao GuananWu QiZhang HuijiangYou ShengjieZhou QiyinWang HeLi ZiyunYe Junjie - Takayasu arteritis (TAK) is a large-vessel vasculitis characterized by chronic vascular inflammation and extracellular matrix (ECM) remodeling. Long non-coding RNAs (lncRNAs) have emerged as epigenetic regulators of inflammatory and structural vascular processes. This study aimed to evaluate whether lncRNA HOTAIR (HOX transcript antisense RNA) expression in peripheral blood mononuclear cells (PBMCs) is associated with circulating mediators involved in ECM turnover in patients with TAK. - Source: PubMed
Publication date: 2026/04/16
Espinosa-Bautista FernandaSoberanes-García María GCastillo-Martínez DianaSpringall RashidiHernández-Díazcouder AdriánAmezcua-Guerra Luis M - Abdominal aortic aneurysm (AAA) lacks effective pharmacological therapies. Here, we investigate transcription factor 7-like 2 (TCF7L2), a genetic locus associated with both thoracic and abdominal aortic aneurysms, to elucidate its role in AAA pathogenesis. Integrating summary-data-based Mendelian randomization (SMR) with single-cell RNA sequencing (scRNA-seq) of human and mouse aortas, we identify TCF7L2 as a gene enriched in vascular smooth muscle cells (VSMCs) and causally linked to AAA development. Smooth muscle cell-specific TCF7L2 knockout significantly attenuates AAA formation across three distinct murine models (Ang II infusion-, BAPN/Ang II co-administration-, and elastase-induced AAA), independent of systemic blood pressure or lipid levels. Mechanistic studies reveal that TCF7L2 directly upregulates MMP14 and downregulates TIMP3 expression in vitro and in vivo, driving MMP2-mediated extracellular matrix (ECM) degradation. Concurrently, TCF7L2 represses integrin β1 (ITGB1) expression, reducing VSMC adhesion to the ECM. Collectively, these findings identify TCF7L2 as a key driver of pathological vascular remodeling in AAA, suggesting that targeting TCF7L2 may offer a novel therapeutic strategy for limiting AAA progression. - Source: PubMed
Publication date: 2026/04/30
Deng YongjieLiu YaozhongZhao YangLiu HongyuZhao GuizhenWang ZhenguoZhang XuXue ChaoHuang WeiZhu TianqingLu HaochengGuo YanhongChang LinSurakka IdaChen Y EugeneZhang Jifeng - DNA methylation of tumour suppressor genes is the most well-studied epigenetic alterations in head and neck cancer. The tumour suppressor genes CDKN2A, RASSF1, and TIMP3 are the most frequently investigated, but the methylation status has been analysed in more than another dozen genes, for example MGMT. In oral squamous cell carcinoma (OSCC) methylation of MGMT, DAPK, and CDKN2A are promising biomarkers of prognostic value. Inhibition of LSD1, encoding a histone demethylase, attenuates the development and growth of OSCC. Methylation of TIMP3 in sinonasal adenocarcinoma (intestinal type) is associated with a significant worse survival, an association not seen in sinonasal squamous cell carcinoma. Olfactory neuroblastoma can be distinguished into four unique subgroups by methylation profiling. Methylation of RASSF1 is seen in NUT carcinoma, and significantly higher RASSF1 methylation is found in SMARCB1/INI1-deficient tumours compared to the less aggressive SMARCB1/INI-proficient tumours. Genome-wide methylation profiling in combination with IDH2 mutation status suggests that tumours with undifferentiable SNUC morphology can be classified into for subgroups. Most salivary gland carcinoma subtypes have specific epigenetic signatures. Four of the most common subtypes, adenoid cystic carcinoma (ADCC), mucoepidermoid carcinoma (MEC), acinic cell carcinoma (ACC), and carcinoma ex pleomorphic adenoma (CXPA) have all methylation of RASSF1A, two (MEC and ADCC) also of TIMP3 and two (MEC and CXPA) of p16INK. A methylation landscape of 20 salivary gland tumours (SGTs) is nowadays available. - Source: PubMed
Publication date: 2026/04/29
Hellquist HenrikCastelo-Branco PedroStenman GöranNadal AlfonsAgaimy AbbasZidar Ninade Lima-Souza Reydson AlcidesMariano Fernanda VivianeCoca-Pelaz AndrésFerlito Alfio - Chronic kidney disease (CKD) is a systemic condition associated with inflammation and oxidative stress, affecting organs beyond the kidneys. Although rarely emphasized, the eyes may also be affected but underlying molecular mechanisms remain largely unexplored. The gut-kidney and gut-eye axes are emerging as therapeutic targets with prebiotics like ResistAid®-a Larch Arabinogalactan (LAG) supplement with antioxidant and immunomodulatory effects-showing promise through gut microbiota modulation. This study assessed ResistAid®'s effects on ocular gene expression in a CKD rat model. Twenty four Wistar rats were assigned to Sham (S), Sham + Treatment (ST), Nephrectomized (N), Nephrectomized + Treatment (NT) ( = 6 each). CKD was induced by 5/6 nephrectomy. The treatment was administered via gavage for 30 days at a dose of 5.35 mg/day, adapted from human recommendations. At day 30, blood and tissues were collected. Expression of antioxidant enzymes () and other genes () was analyzed by qPCR. Biochemical and well-being assessments were also conducted. Nephrectomy, regardless of treatment, increased and expression in eye and blood; Specific to NT animals, ocular , and expressions were markedly elevated when compared with N animals and blood and ocular expressions were not elevated, differing from N animals. No significant changes were observed between the S and ST groups. CKD induces systemic oxidative and inflammatory responses. ResistAid® partially mitigated these effects in blood and eye, suggesting systemic and local benefits, possibly via gut microbiota modulation. - Source: PubMed
Publication date: 2026/04/29
Alves Reis Pedro HenriqueDestro Isabela de PaulaLamy Ingrid BertolliniPetri GiulianaSilvestri Estella FreitasTrufelli Isabella Dudjak RosaAlves Beatriz da Costa AguiarLima Vagner Loducada Veiga Glaucia LucianoFonseca Fernando Luiz Affonso