Recombinant Human OPG _ TNFRSF11b [+His] Proteins
- Known as:
- Recombinant Human OPG _ TNFRSF11b [+histidine] Proteins
- Catalog number:
- 228-11176-2
- Product Quantity:
- 50
- Category:
- -
- Supplier:
- Ray Biotech
- Gene target:
- Recombinant Human OPG _ TNFRSF11b [+His] Proteins
Related genes to: Recombinant Human OPG _ TNFRSF11b [+His] Proteins
- Gene:
- HARS NIH gene
- Name:
- histidyl-tRNA synthetase
- Previous symbol:
- USH3B
- Synonyms:
- HisRS
- Chromosome:
- 5q31.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2019-04-23
- Gene:
- TNFRSF11B NIH gene
- Name:
- TNF receptor superfamily member 11b
- Previous symbol:
- OPG
- Synonyms:
- OCIF, TR1
- Chromosome:
- 8q24.12
- Locus Type:
- gene with protein product
- Date approved:
- 1997-09-05
- Date modifiied:
- 2016-10-05
- Gene:
- TRH-GTG1-1 NIH gene
- Name:
- tRNA-His (anticodon GTG) 1-1
- Previous symbol:
- TRNAH4
- Synonyms:
- tRNA-His-GTG-1-1
- Chromosome:
- 1q21.1
- Locus Type:
- RNA, transfer
- Date approved:
- 2008-08-21
- Date modifiied:
- 2019-04-04
- Gene:
- TRH-GTG1-2 NIH gene
- Name:
- tRNA-His (anticodon GTG) 1-2
- Previous symbol:
- TRNAH10
- Synonyms:
- tRNA-His-GTG-1-2
- Chromosome:
- 1q21.1
- Locus Type:
- RNA, transfer
- Date approved:
- 2008-08-29
- Date modifiied:
- 2019-04-04
- Gene:
- TRH-GTG1-3 NIH gene
- Name:
- tRNA-His (anticodon GTG) 1-3
- Previous symbol:
- TRNAH9
- Synonyms:
- tRNA-His-GTG-1-3
- Chromosome:
- 1q21.2
- Locus Type:
- RNA, transfer
- Date approved:
- 2008-08-29
- Date modifiied:
- 2019-04-04
Related products to: Recombinant Human OPG _ TNFRSF11b [+His] Proteins
Related articles to: Recombinant Human OPG _ TNFRSF11b [+His] Proteins
- In this cohort, we explored the DNA methylation changes of 3 genes of the canonical Wnt/β-catenin and RANKL/OPG pathways related to bone homeostasis in cord blood at birth. Those mothers with poor sleep quality in the first trimester of pregnancy had 5.9 times higher odds of complete OPG methylation compared to those with good sleep (adjusted OR = 5.9; 95% CI 1.04-33.0; p = 0.045). Maternal lifestyle factors during pregnancy can influence fetal development through epigenetic mechanisms, potentially affecting neonatal skeletal programming and long-term bone health. Sleep quality is an important, modifiable maternal factor, but its role in shaping epigenetic regulation of bone development remains unclear. We aimed to investigate the association between maternal sleep quality during pregnancy and DNA methylation of key genes of the canonical Wnt/β-catenin signaling pathway, Wnt Family Member 10B (WNT10B), β-catenin (CTNNB1), and osteoprotegerin (OPG or TNFRSF11B) in the offspring's cord blood samples at birth. A total of 300 pregnant women were recruited as a sub-study of the PERSIAN Birth Cohort-Isfahan. Maternal sleep patterns were assessed using the Pittsburgh Sleep Quality Index (PSQI). Methylation at cytosine-guanine (CpG) dinucleotide sites within the promoters of WNT10B, β-catenin, and OPG was quantified in offspring's cord blood at birth, and associations with maternal sleep quality across all trimesters were assessed. Poor sleep quality in the first trimester was significantly associated with increased OPG methylation (adjusted OR = 1.40, 95% CI 1.05-1.8, p = 0.023). Mothers with poor sleep quality (PSQI ≥ 5) in the first trimester had 5.9 times higher odds of complete OPG methylation compared to those with good sleep quality (adjusted OR = 5.9, 95% CI 1.04-33.0, p = 0.045). However, associations with WNT10B and β-catenin were not statistically significant. Maternal sleep quality during early gestation may influence the DNA methylation and epigenetic programming of bone-related genes in neonatal cord blood, emphasizing the importance of maternal lifestyle as a modifiable factor shaping early-life bone health. - Source: PubMed
Publication date: 2026/05/28
Baradaran Mahdavi SadeghNiazmand AnooshaJavadirad Seyed MortezaDaniali Seyede ShahrbanooMozafarian NafisehRoudashti ShekoufehHeidari-Beni MotaharRafieian MahsaBemanalizadeh MaryamPoursafa ParnianAzimian Zavareh VajiheFeizi AwatSalehi RasoulKelishadi Roya - Poor bone quality in osteoporotic patients remains a major challenge for achieving predictable osseointegration. This study serves as a mechanistic complement to previously reported structural data, aiming to investigate the molecular pathways underlying the synergy between nanostructured surfaces and autologous blood concentrates in compromised bone. Ninety-six Wistar rats were divided into healthy (SHAM) and osteoporotic (OVX) groups. Implants with nanostructured hydroxyapatite (NanoHA) or dual acid-etched (DAE) surfaces were installed in the tibiae, associated or not with leukocyte- and platelet-rich fibrin (). Gene expression (RT-qPCR) for , , , , , and was assessed at 7 and 30 days. In compromised systemic conditions (OVX), the NanoHA + association promoted a robust "molecular rescue" of bone metabolism. At 30 days, this synergistic group exhibited a significant upregulation of (mean: 11.69 ± 1.65) and (mean: 4.49 ± 0.82) compared to DAE controls ( < 0.05). Crucially, the therapy orchestrated a protective remodeling environment by significantly inducing expression (5.50 ± 0.88), effectively balancing the / ratio. Late-stage maturation markers ( and ) were also significantly elevated, effectively mimicking healthy physiological levels observed in the SHAM group. NanoHA biofunctionalization, synergistically with L-PRF, triggers a transcriptional reprogramming of the peri-implant microenvironment, mitigating the catabolic effects of estrogen deficiency. These findings provide a biological foundation for enhanced clinical predictability in high-risk patients, suggesting that local interfacial modifications can overcome systemic bone compromise. - Source: PubMed
Publication date: 2026/05/17
Barbosa Ana Carolina LoyolaJúnior José Augusto Gabarrada Silva Lilian Eslaine Costa MendesNóbrega FernandoBergamo Edmara Tatiely PedrosoGhiraldini BrunaE Pessoa Roberto SalesMessora Michel ReisSouza Sergio Scombatti de - Fabry disease is an X-linked lysosomal storage disorder caused by α-galactosidase A deficiency, leading to progressive accumulation of Gb3 and lyso-Gb3 and a complex multisystem phenotype extending beyond substrate storage. Cardiovascular involvement remains the leading cause of morbidity and mortality, yet early detection and risk stratification remain challenging. In this context, a new proteomic study leveraging high-throughput proximity extension assays and machine learning has defined a cardiovascular risk signature in Fabry disease. Differential expression analysis identified widespread proteomic remodeling involving inflammatory signaling, extracellular matrix organization, angiogenesis, and metabolic pathways, supporting a systems-level view of disease pathogenesis. A 10-protein biosignature integrating markers of mitochondrial stress, lysosomal function, vascular remodeling, and immune activation demonstrated the ability to discriminate patients with cardiovascular involvement. Notably, proteins such as GDF15, NT-proBNP, NOS1, CTSF, and TNFRSF11B highlight the interplay between mitochondrial dysfunction, lysosomal impairment, and vascular inflammation. These findings suggest that Fabry cardiomyopathy reflects coordinated dysregulation across metabolic and inflammatory networks and that multi-protein signatures may improve precision phenotyping and cardiovascular risk prediction beyond conventional biomarkers. - Source: PubMed
Publication date: 2026/05/22
Santulli GaetanoPande ShivangiVarzideh Fahimeh - Microgravity is one type of external stimulus that affects bone homeostasis and bone development. This study investigates the molecular drivers of these effects in order to more fully understand the cellular communication network between bone cells when bone homeostasis is perturbed. - Source: PubMed
Publication date: 2026/05/04
Carvajal-Agudelo Juan DFranz-Odendaal Tamara A - Periodontitis is a chronic inflammatory disease affecting tooth-supporting structures, while depression is a common mental disorder with emotional and behavioral disturbances. Previous studies suggest a potential association between the two conditions. This study aimed to evaluate salivary concentrations of Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL) and Osteoprotegerin (OPG)-key regulators of osteoclast activity and periodontal bone resorption-in patients with periodontitis and depression. - Source: PubMed
Esmaeilnejad AzadehLafzi ArdeshirNeishabouri Seyedeh MorvaridBigham Mohammad Mohsen