Anti Human cTnT, Clone 8C11
- Known as:
- Anti Human cTnT, Clone 8C11
- Catalog number:
- CTNT8C11
- Product Quantity:
- 0.1 mg
- Category:
- -
- Supplier:
- Molinn
- Gene target:
- Anti Human cTnT Clone 8C11
Related genes to: Anti Human cTnT, Clone 8C11
- Gene:
- ACSS1 NIH gene
- Name:
- acyl-CoA synthetase short chain family member 1
- Previous symbol:
- ACAS2L
- Synonyms:
- dJ568C11.3, AceCS2L, MGC33843
- Chromosome:
- 20p11.21
- Locus Type:
- gene with protein product
- Date approved:
- 2001-07-17
- Date modifiied:
- 2019-03-22
Related products to: Anti Human cTnT, Clone 8C11
Related articles to: Anti Human cTnT, Clone 8C11
- This study integrates single-cell and bulk RNA-seq to investigate cell type-specific alterations in fatty acid metabolism-related genes in the dorsolateral prefrontal cortex (DLPFC) of schizophrenia (SCZ) patients and to evaluate their potential as diagnostic biomarkers. - Source: PubMed
Publication date: 2026/04/21
Zhao CuiZhang LiangYang PingLi LiangZeng WeiqiXie Weiqi - The presence of chlortetracycline (CTC) in swine wastewater poses a threat to anaerobic treatment and ecological safety. This study investigated the concentration-dependent effects of CTC on methanogenesis, microbial properties, and antibiotic resistance genes in an anaerobic ceramic membrane bioreactor (AnCMBR). Batch assays identified a biological inhibition threshold at 50 mg/L CTC. During long-term operation, CTC at 10 mg/L (after a brief adaptation) increased methane yield by 28%, while 50 mg/L CTC inhibited methanogenesis and reduced COD removal from 97% to 86%. High-level CTC raised antibiotic resistance gene abundance and decreased acute toxicity removal from 68% to 46%. Biodegradation dominated CTC removal, but its contribution declined from 42% to 19% as CTC increased, lowering overall removal from 60% to 30%. Metagenomic analysis revealed that low-level CTC upregulated hydrolysis/fermentation-related genes (e.g., enolase, phosphoglycerate mutase, pyruvate kinase), enhancing substrate supply for methanogenesis. In contrast, high-level CTC markedly enriched Spirochaetes (from 3% to 66%), suppressed key methanogenic genes involved in methyl-CoM reductase and downstream acetyl-CoA metabolism, while preserving acetoclastic pathway genes (acsS1.2, ackA, pta), collectively shifting the pathway toward acetoclastic methanogenesis. Notably, the AnCMBR maintained stable filtration performance, with the transmembrane pressure remaining below 6.5 kPa over 160 days. These findings demonstrate that low CTC levels can be tolerated after acclimation, whereas high CTC stress severely impairs methanogenesis, detoxification, and biosafety. - Source: PubMed
Publication date: 2026/05/02
Zhang QiaoqingHu YisongWang GuanqianKong LingyiXu ZhenqiMa XiaoyanChen Rong - Huoshou black pig (HS) is a well-known indigenous Chinese breed distinguished by superior meat quality compared to Western breeds. To investigate the molecular mechanisms underlying these differences, we performed Data-Independent Acquisition(DIA) proteomic analysis on the longissimus dorsi (LD) muscle from HS and Yorkshire (YY) pigs. We identified 262 differentially expressed proteins (DEPs), including 134 upregulated and 128 downregulated in HS relative to YY. Functional enrichment analysis revealed that these DEPs were significantly involved in small molecule metabolism, oxidoreductase activity, and several key signaling pathways such as the mTOR, AMPK, and PI3K-Akt pathways. Protein -protein interaction network analysis highlighted roles in structural proteins, glycolysis, and ribosome biogenesis. Integrated transcriptomic and proteomic analysis identified five candidate genes (MGST2, PNPO, CALD1, NCAM1, ACSS1) potentially associated with meat quality traits. Parallel reaction monitoring (PRM) and quantitative PCR (qPCR) validated the consistent differential expression of these genes at both the protein and mRNA levels. These findings provide novel insights into the molecular mechanisms regulating pork quality in indigenous pig breeds. - Source: PubMed
Publication date: 2026/04/30
Cao HanyuLi XiaojinXie FeiJiang ChangshengJin MengmengGhonaim Ahmed HRen ManHu QianqianLi Shenghe - Loss of cardiomyocytes during hypoxia-reoxygenation injury contributes to adverse myocardial remodeling, resulting in hypertrophy of surviving cardiomyocytes, interstitial fibrosis, and ultimately, heart dysfunction. Despite extensive research in the field, there is currently no specific treatment available for myocardial hypoxia-reoxygenation injury to prevent cardiomyocyte death. Prenylcysteine oxidase 1 (PCYOX1) is a pro-oxidant, FAD-dependent thioether oxidase that generates hydrogen peroxide during prenylcysteine metabolism, but its role in cardiomyocytes is poorly defined. Here, using HL-1 cardiomyocytes stably silenced for Pcyox1, we show that PCYOX1 contributes to both basal and stress-induced oxidative burden and cell death. Pcyox1 silencing reduced reactive oxygen species (ROS) levels at baseline and blunted the ROS increase during ischaemic/hypoxic stress. Consistently, Pcyox1 silencing decreased apoptosis after prolonged ischaemic/hypoxic exposure. Quantitative proteomics of whole-cell lysates and isolated mitochondria revealed coordinated remodeling of pathways involved in energy buffering and contractile machinery, including increased abundance of mitochondrial creatine kinases (CKMT1/CKMT2), acetyl-CoA synthetase 2-like (ACSS1), and multiple myosin components, changes that persisted under ischaemic/hypoxic stress and after reoxygenation. Overall, these data identify PCYOX1 as a modulator of redox homeostasis and proteomic adaptation in cardiomyocytes and support PCYOX1 inhibition as a potential strategy to limit hypoxia-reoxygenation-associated injury. - Source: PubMed
Banfi CristinaBrocca LisaBascucci AlicePapaianni Giulia GiusyMallia AliceEligini Sonia - Although the combination of surgery and chemotherapy has dramatically improved the prognosis of patients with osteosarcoma (OS), the prognosis of OS patients with metastatic or recurrent tumors remains poor. Here, we found significant upregulation of the acetyl-CoA synthesis-related pathway in OS patients with metastases. - Source: PubMed
Publication date: 2026/04/01
He XiumingLuo MengliangWang ChenyangKong LingkaiLi JianglongTan JianyeChen JunhaoNie YiChen HantaoZou ZhipengSu ZexinLin Lijun