Sheep Toll Like Receptor2 ELISA , TLR2
- Known as:
- Sheep Toll Like Receptor2 Enzyme-linked immunosorbent assay test , TLR2
- Catalog number:
- E14T0068
- Product Quantity:
- 96 Tests/kit
- Category:
- -
- Supplier:
- BGene
- Gene target:
- Sheep Toll Like Receptor2 ELISA TLR2
Related genes to: Sheep Toll Like Receptor2 ELISA , TLR2
- Gene:
- TLR2 NIH gene
- Name:
- toll like receptor 2
- Previous symbol:
- -
- Synonyms:
- TIL4, CD282
- Chromosome:
- 4q31.3
- Locus Type:
- gene with protein product
- Date approved:
- 1998-06-25
- Date modifiied:
- 2016-10-25
- Gene:
- TLR4 NIH gene
- Name:
- toll like receptor 4
- Previous symbol:
- -
- Synonyms:
- hToll, CD284, TLR-4, ARMD10
- Chromosome:
- 9q33.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-06-25
- Date modifiied:
- 2016-01-21
Related products to: Sheep Toll Like Receptor2 ELISA , TLR2
Related articles to: Sheep Toll Like Receptor2 ELISA , TLR2
- Hepatic ischemia-reperfusion injury (IRI) is a complex event influenced by interconnected immune and metabolic processes. Steatotic livers are especially sensitive to IRI, but the crosstalk between innate inflammatory responses and lipid metabolic dysregulation in this context is not well understood. Using transcriptomic profiling in a murine high-fat diet (HFD) model, we assessed immune and metabolic responses to hepatic IRI and examined the effects of N-acetylcysteine (NAC). In steatotic livers, IRI induced the upregulation of inflammatory mediators, including TLR/NF-κB-associated genes (, , ) and neutrophil-associated genes (, ), accompanied by the downregulation of lipid and cholesterol metabolism-related genes, including , , , and . NAC supplementation attenuated inflammatory gene expression and restored key lipid biosynthetic regulators. We then performed targeted lipidomic analysis to determine whether NAC-mediated transcriptional changes were reflected at the lipid level and observed a significant increase in total phosphatidylcholine and sphingomyelin in steatotic livers following IRI. Finally, to assess the contribution of innate immune cells to hepatic IRI, we quantified neutrophils and macrophages in HFD+NAC IRI and HFD IRI livers. We found that NAC supplementation reduced hepatic neutrophil accumulation and markedly decreased LCN2 expression following IRI. - Source: PubMed
Publication date: 2026/05/19
Kang JimanPatil DigvijayHackett RyanCui YukiOza KeshaRutkowski AbigailLiggett Jedson RLi HenghongRanjit SumanKwon DongHyangKallakury BhaskarAlbanese ChrisGondolesi Gabriel EEkong UdemeCui WanxingKhan KhalidFishbein Thomas MKroemer Alexander - Infectious laryngotracheitis (ILT) is a significant respiratory disease that impacts poultry populations worldwide, known as ILT virus (ILTV). This viral disease presents considerable challenges not only to poultry health but also to the broader food industry, resulting in substantial economic losses and posing a risk to food security. Effective control and prevention of ILT are paramount, and vaccination strategies have emerged as critical measures in mitigating the impact of this disease. The envelope glycoproteins of ILTV are essential for the virus's ability to enter host cells, making them potential targets for vaccine development. However, to date, there has been a lack of comprehensive research focused on the evaluating these glycoproteins for their immunogenic potential in the context of ILTV vaccination. - Source: PubMed
Publication date: 2025/09/01
Parisa JamourMaryam MeskiniNarjes Noori GoodarziBehrouz EbadiAsghar Abdoli - The small size of nanoplastics (NPs; <1 µm in diameter) facilitates airborne transport, inhalation, and deposition in the lungs, raising significant concerns about potential effects on human health. In occupational settings, such as waste management and recycling facilities, exposure to NPs carrying microbial contaminants may pose an additional health risk to workers. In the present study, we investigated pulmonary cytotoxicity and pro-inflammatory responses after exposure to polyethylene terephthalate nanoplastics (PET-NPs) with or without microbial contaminants. - Source: PubMed
Publication date: 2026/05/18
Haugen Øyvind PSagen Andreas SolbergBarbero FrancescoAlcolea-Rodriguez VictorPortela RaquelFenoglio IvanaBrinchmann Bendik CWallin HåkanZienolddiny-Narui ShanAfanou Anani K - Effective vaccines against Trypanosoma cruzi, the causative agent of Chagas disease, are urgently needed. Here, we report the design and in silico validation of a novel multiepitope vaccine construct targeting the key surface proteins ASP-2 and gp82. Using a comprehensive immunoinformatics pipeline, we identified and selected 38 potent T-cell (CTL/HTL) and B-cell epitopes, ensuring high antigenicity, immunogenicity, and safety. The final chimeric protein, integrated with adjuvants and stabilizing linkers, demonstrated favorable physicochemical properties, high solubility, and was predicted to be non-allergenic and non-toxic, with a significant population coverage of approximately 62% in Latin America. Structural modeling and refinement confirmed a stable tertiary structure. Crucially, molecular docking predicted high-affinity interactions with the immune receptors TLR2 and TLR4 (docking scores: -1360.4 and -1278.7, respectively). The stability and flexibility of these vaccine-receptor complexes were further validated by 300 ns molecular dynamics simulations. Finally, codon optimization and in silico cloning projected high expression potential in an Escherichia coli system. Immune simulations predicted robust responses: Innate (elevated cytokines, dendritic cell activation), humoral (IgG/IgM production), and cellular (CD4+/CD8+/memory T-cell activation) across simulated doses. These findings strongly support the potential of this vaccine candidate and provide a solid foundation for its further preclinical development against T. cruzi. - Source: PubMed
Publication date: 2026/05/29
Silva Maria Karolaynne daSena Caio Patrício de SouzaVieira Davi SerradellaZaki Magdi E AYee Leow ChiuanAkter ShahinaFulco Umberto LainoOliveira Jonas Ivan NobreRodrigues-Neto João Firmino - Infection by SARS-CoV-2 is associated with an uncontrolled and damaging inflammatory response during severe COVID-19 disease, during which immune cells, such as neutrophils, monocytes, and macrophages, release pro-inflammatory mediators leading to the development of acute respiratory distress syndrome. Mast cells may also contribute to the pathogenesis of COVID-19, as increased serum levels of their proteases are associated with the severity of the disease. Mast cells are strategically located in tissues that interface with the external environment, such as the skin, respiratory tract, and gastrointestinal mucosa, exhibiting microbicidal activities, including phagocytosis and the release of DNA embedded with granular proteins, known as DNA extracellular traps (DETs). - Source: PubMed
Publication date: 2026/05/29
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