Sheep Synaptopodin ELISA , SYNPO
- Known as:
- Sheep Synaptopodin Enzyme-linked immunosorbent assay test , SYNPO
- Catalog number:
- E14S0219
- Product Quantity:
- 96 Tests/kit
- Category:
- -
- Supplier:
- BGene
- Gene target:
- Sheep Synaptopodin ELISA SYNPO
Related genes to: Sheep Synaptopodin ELISA , SYNPO
- Gene:
- SYNPO NIH gene
- Name:
- synaptopodin
- Previous symbol:
- -
- Synonyms:
- KIAA1029
- Chromosome:
- 5q33.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-01-12
- Date modifiied:
- 2015-08-26
Related products to: Sheep Synaptopodin ELISA , SYNPO
Related articles to: Sheep Synaptopodin ELISA , SYNPO
- The design, synthesis, and comprehensive characterization of six novel halogenated azobenzene acrylate monomers bearing fluorine, chlorine or bromine substituents is reported. The monomers were prepared via a facile three-step synthetic route involving azo-coupling, alkylation and -acylation. Apart from the steady electrochemical properties, halogen substitution proved to be a very useful tool to tune the thermal and optical properties, light-induced switching in particular. Monohalogen derivatives exhibited up to 93% → photoconversion efficiency in solution, whereas the efficiency of dihalogen analogues is lower by 20%, which is ascribed to their nonplanar arrangement. Kinetics studies identified the most stable -isomer of the difluoro derivative ( = 3.74/6.59 h at 60 °C in DCE/CDCl). The monofluoro derivative embedded in a polystyrene film demonstrated photoresponsive behavior and remarkable stability by maintaining a macroscopically visible color change for over 90 days. These findings demonstrate that -halogenation is a powerful tool for tuning the properties of photoresponsive materials for potential applications in colorimetric thermal sensing and light-controlled functional systems. - Source: PubMed
Publication date: 2026/05/21
Vachtlová MartinaFecková MichaelaZima VítězslavPodlesný JanKlikar MilanPytela OldřichPařík PatrikOpršal JakubJuhaňáková EliškaChrtová VeronikaBureš Filip - We previously reported that germline complement deletion protected cognition and hippocampal synapses in aged APP/PS1dE9 mice despite increased amyloid plaques. To assess whether global C3 lowering in adult amyloid mice might be neuroprotective, we crossed our C3 inducible conditional mice with knockin mice. - Source: PubMed
Publication date: 2025/12/20
Singh BrijendraBatista Andre FSpooner Emma TColletti Brianna RSaido Takaomi CCarroll Michael CLemere Cynthia A - Intracerebral Hemorrhage (ICH) is a stroke subtype with high mortality, and its core pathological mechanism involves the disruption of cerebrovascular homeostasis. Genetic factors play a crucial role in ICH pathogenesis, underscoring the importance of identifying core regulatory factors and delineating the associated pathological network. Here, through genome-wide association study (GWAS), we identified synaptopodin () as a genetic susceptibility gene for ICH. SYNPO is an evolutionarily conserved actin-binding protein previously shown to be highly expressed in cerebrovascular endothelial cells, where it regulates the actin cytoskeleton to maintain endothelial junction stability. However, its functional role in ICH remains unclear. To investigate this, we conducted a mutant zebrafish line using CRISPR/Cas9. Following epinephrine challenge, mutant larvae displayed significantly elevated cerebrovascular leakage compared with wild-type controls, and adult mutants showed a markedly higher incidence of ICH. Transcriptomic profiling revealed significant downregulation of the key adhesion gene in mutant brains. Subsequent rescue experiments confirmed that mRNA supplementation effectively ameliorated the cerebrovascular leakage. In summary, our study unveils a pathway in which maintains cerebrovascular homeostasis by positively regulating , demonstrating that the axis serves as a key regulatory pathway in ICH. These findings provide insights into the genetic mechanisms underlying ICH and highlight potential therapeutic targets. - Source: PubMed
Ouyang Pei-DongTang Jia-LanWu Cheng-ChaoLi Xiao-YuKe Shan-ShanZhang Jing-Jing - Fine-grained video captioning aims to generate detailed, temporally coherent descriptions of video content. However, existing methods struggle to capture subtle video dynamics and rich detailed information. In this paper, we leverage preference learning to enhance the performance of vision-language models (VLM) in fine-grained video captioning, while mitigating several limitations inherent to Direct Preference Optimization (DPO). First, we propose a pipeline for constructing preference pairs that leverages the intrinsic properties of VLMs along with partial assistance from large language models, achieving an balance between cost and data quality. Then, we propose Synergistic Preference Optimization (SynPO), a novel optimization method offering significant advantages over DPO and its variants. SynPO prevents negative pReferences from dominating the training, explicitly preserves the model's language capability to avoid deviation of the optimization objective, thus obtains high-quality captions and improves training efficiency by eliminating the need for the reference model. We extensively evaluate our proposed data construction pipeline across three models: AuroraCap, LLaVA1.6-7B-Video and InterVL2-8B. Results demonstrate that our method improve performance in fine-grained video captioning significantly and consistenly. Source code is available at https://github.com/longmalongma/SynPO. - Source: PubMed
Dang JishengZhang YizhouYe HaoWang TengGuo YulanHu Bin - Synaptopodin (SYNPO), founding member of the family of podin proteins, was mainly studied in the kidney and the brain. Here, SYNPO was initially described to be expressed in renal podocytes and the endoplasmic reticulum (ER-)related spine apparatus in dendritic spines, respectively. More recently, SYNPO expression was also reported in epithelial cells, and database analyses even indicate ubiquitous expression, including high expression in striated and smooth muscle cells. Hrt (hard return) our analyses at RNA and protein levels confirm expression of distinct SYNPO variants in all striated and smooth muscle cell-containing organs analyzed and identify isoform-specific expression of SYNPO in human and mouse tissues. Immunostaining of tissue sections revealed diffuse localization at myofibrillar Z-discs in striated muscle fibers and at intercalated discs of cardiomyocytes. In skeletal muscle fibers, but also in cardiomyocytes, SYNPO partially colocalizes with longitudinal sarcoplasmic reticulum (SR-)associated STIM1. In smooth muscle cells, SYNPO shows a reticular distribution, compatible with potential co-distribution with the SR in these cells. In addition to previously reported interactions with actin and α-actinin, our protein interaction studies reveal a small region of SYNPO, homologous to the filamin C (FLNc)-binding region of SYNPO2, to bind FLNc. Transfection of SYNPO isoforms indicate close association with myofibrillar Z-discs in skeletal myotubes as well as stress fiber dense bodies and focal adhesions in smooth muscle cells. Our data identify strong expression of SYNPO variants in all muscle cell types, and indicate a role for SYNPO in the interaction between the actin cytoskeleton and the sarcoplasmic reticulum. - Source: PubMed
Publication date: 2026/04/04
Lohanadan KeerthikaAssent MarvinLinnemann AnjaQu ChengqingSchänzer AnneHeukamp LukasMilting HendrikKirfel GregorMiner Jeffrey HFürst Dieter Ovan der Ven Peter F M