Human Forkhead Box Protein C1 ELISA , FOXC1
- Known as:
- Human Forkhead Box Protein C1 Enzyme-linked immunosorbent assay test , FOXC1
- Catalog number:
- E01F0116
- Product Quantity:
- 96 Tests/kit
- Category:
- -
- Supplier:
- BGene
- Gene target:
- Human Forkhead Box Protein C1 ELISA FOXC1
Related genes to: Human Forkhead Box Protein C1 ELISA , FOXC1
- Gene:
- FOXC1 NIH gene
- Name:
- forkhead box C1
- Previous symbol:
- FKHL7, IRID1
- Synonyms:
- FREAC3, ARA, IGDA, IHG1
- Chromosome:
- 6p25.3
- Locus Type:
- gene with protein product
- Date approved:
- 1995-06-05
- Date modifiied:
- 2019-04-23
Related products to: Human Forkhead Box Protein C1 ELISA , FOXC1
Related articles to: Human Forkhead Box Protein C1 ELISA , FOXC1
- Juvenile-onset open-angle glaucoma (JOAG) is a heterogeneous early-onset glaucoma subtype. Axenfeld-Rieger syndrome (ARS) is an autosomal dominant disorder caused by variants, which may present with severe early-onset glaucoma and can be clinically mistaken for JOAG. This study aimed to determine the genetic cause and clarify the clinical diagnosis in a Chinese family initially diagnosed with JOAG. - Source: PubMed
Publication date: 2026/06/08
Lin BinLi LiLi Dong-Kan - - Source: PubMed
Mokry Michal - - Source: PubMed
Publication date: 2026/06/19
Gruenauer-Kloevekorn ClaraMaka ErikaImre LászlóZoltán Nagy ZsoltJávorszky EszterTory KálmánCsákány BelaSzentmáry Nóra - Dandy-Walker malformation (DWM) is a condition characterized by a cyst in the posterior cranial fossa contiguous with the fourth ventricle, combined with complete or partial agenesis of the cerebellar vermis; and elevation of the cerebellar tentorium, torcular Herophili, and transverse sinuses. DWM has been linked to specific genetic variants, with pathogenic or likely pathogenic variants reported in FOXC1, ZIC1, and ZIC4. Variants in the TUBB2B and TUBB3 genes are associated with abnormalities in tubulin, leading to cerebellar hypoplasia. In our study, three patients diagnosed with DWM underwent whole-genome analysis using next-generation sequencing, and two were found to have heterozygous variants in the tubulinopathy-associated genes TUBB2B and TUBB3, respectively. These findings indicate that some cases previously diagnosed as DWM may fall under the spectrum of tubulinopathies associated with cerebellar hypoplasia. - Source: PubMed
Publication date: 2026/06/17
Ueno KatsuyaHigasa KoichiroHayashi MikioIsozaki HarunaMiyata MayukoNaito NobuakiLi YiTakeda JunichiNonaka Masahiro - Acute myeloid leukemia (AML) is a genetically and phenotypically heterogeneous hematological malignancy. Here, to better define this clinically taxing and translationally challenging malignancy, we applied a multiomics approach, consisting of 13 modalities to analyze 173 treatment-naive individuals with AML. By integrating these 'omes', we identified distinct AML subtypes, genotype-phenotype associations, biomarkers and pathobiological mechanisms. Across the spectrum of primitive and committed AML, we found extensive metabolomic and lipidomic reprogramming driven by divergent MYC and mTOR activity. We linked metabolic changes to striking hyperacetylation of mitochondrial proteins in CEBPA-mutant AML. Protein-centric subtyping revealed a distinct NPM1-mutant subset characterized by outlier expression of FOXC1 and HOXB8/9. To nominate therapeutic targets across subtypes, we developed a multiomic machine-learning approach and validated MTA1 as a contributor to panobinostat resistance. Altogether our findings underscore the complex nature of AML and provide a clinically and translationally informed unified view that reveals coalescent phenotypes across multiomic layers. - Source: PubMed
Publication date: 2026/06/12
Chu Shih-Chun AHsiao YiWang ChenweiKyle Jennifer EJain RaghavDeng YameiGritsenko Marina AHenry Leanne ELei Jonathan TDou YongchaoTercan BaharShi ZhiaoGondal Mahnoor NTsai Chia-FengElizarraras John MChu Rosalie KYu FengchaoJoshi Sunil KJing XiaojunPolasky Daniel AWeitz Karl KLi Ginny XiaohePaurus Vanessa LClendinen Chaevien SSchepmoes Athena ALalli Priscila MEder Josie GFlores Javier EStratton Kelly GPino James CPosso CamiloPetyuk Vladislav ASagendorf Tyler JXu YuanweiIbrahim Omar MMoore Ronald JZhao RuiChen JinMonroe Matthew EThiagarajan MathangiHostetter GalenNewton ChelseaAn EunkyungRobles Ana IZhang XuEdwards Nathan JLu YinZhang HuiAbdelhakim HaithamPiehowski Paul DMesri MehdiSmith Richard DKumar-Sinha ChandanTognon Cristina EDunlap JenniferTraer ElieDing LiTyner Jeffrey WChinnaiyan Arul MOmenn Gilbert SRodland Karin DDhanasekaran Saravana MGosline Sara J CNesvizhiskii Alexey IZhang BingLiu TaoCieslik Marcin P