Human Elongin A ELISA , ELOA
- Known as:
- Human Elongin A Enzyme-linked immunosorbent assay test , ELOA
- Catalog number:
- E01E0051
- Product Quantity:
- 96 Tests/kit
- Category:
- -
- Supplier:
- BGene
- Gene target:
- Human Elongin ELISA ELOA
Related genes to: Human Elongin A ELISA , ELOA
- Gene:
- ELOA NIH gene
- Name:
- elongin A
- Previous symbol:
- TCEB3
- Synonyms:
- SIII, TCEB3A
- Chromosome:
- 1p36.11
- Locus Type:
- gene with protein product
- Date approved:
- 1995-09-14
- Date modifiied:
- 2017-02-10
- Gene:
- ELOA3 NIH gene
- Name:
- elongin A3
- Previous symbol:
- TCEB3C
- Synonyms:
- HsT829, TCEB3L2, ELOA3A
- Chromosome:
- 18q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-01-16
- Date modifiied:
- 2016-11-08
Related products to: Human Elongin A ELISA , ELOA
Related articles to: Human Elongin A ELISA , ELOA
- The biological role of the repetitive DNA sequences in the human genome remains an outstanding question. Recent long-read human genome assemblies have allowed us to identify a function for one of these repetitive regions. We have uncovered a tandem array of conserved primate-specific retrogenes encoding the protein Elongin A3 (ELOA3), a homolog of the RNA polymerase II (RNAPII) elongation factor Elongin A (ELOA). Our genomic analysis shows that the gene cluster is conserved among primates and the number of gene repeats is variable in the human population and across primate species. Moreover, the gene cluster has undergone concerted evolution and homogenization within primates. Our biochemical studies show that ELOA3 functions as a promoter-associated RNAPII pause-release elongation factor with distinct biochemical and functional features from its ancestral homolog, ELOA. We propose that the gene cluster has evolved to fulfil a transcriptional regulatory function unique to the primate lineage that can be targeted to regulate cellular hyperproliferation. - Source: PubMed
Publication date: 2023/11/22
Morgan Marc A JMohammad Parast SaeidIwanaszko MartaAoi YukiYoo DongAhnDumar Zachary JHoward Benjamin CHelmin Kathryn ALiu QianliThakur William RZeidner Jacob MSinger Benjamin DEichler Evan EShilatifard Ali