Human Bone Morphogenetic Protein 6 ELISA , BMP6
- Known as:
- Human Bone Morphogenetic Protein 6 Enzyme-linked immunosorbent assay test , BMP6
- Catalog number:
- E01B0395
- Product Quantity:
- 96 Tests/kit
- Category:
- -
- Supplier:
- BGene
- Gene target:
- Human Bone Morphogenetic Protein 6 ELISA BMP6
Related genes to: Human Bone Morphogenetic Protein 6 ELISA , BMP6
- Gene:
- BMP6 NIH gene
- Name:
- bone morphogenetic protein 6
- Previous symbol:
- VGR
- Synonyms:
- VGR1
- Chromosome:
- 6p24.3
- Locus Type:
- gene with protein product
- Date approved:
- 1991-06-05
- Date modifiied:
- 2016-10-05
Related products to: Human Bone Morphogenetic Protein 6 ELISA , BMP6
Related articles to: Human Bone Morphogenetic Protein 6 ELISA , BMP6
- Osteosarcopenia-the concurrent presence of osteoporosis and sarcopenia-affects approximately 18.5% of older adults globally, yet its shared genetic basis remains poorly understood. We applied genomic structural equation modeling (Genomic SEM) to integrate genome-wide association study (GWAS) summary statistics across five phenotypes spanning the pathophysiological spectrum of osteosarcopenia: appendicular lean mass (ALM), bone mineral density (BMD), handgrip strength (HGS), walking pace, and fracture. Fine-mapping, transcriptome-wide association study (TWAS), pathway enrichment, cell-type enrichment, and spatial transcriptomic mapping were performed to functionally annotate the identified loci. A single-factor model (CFI = 0.976) captured the shared genetic liability, with HGS and ALM loading most strongly. A two-factor sensitivity analysis confirmed partial separability of muscle and bone dimensions, though the single common factor was retained for integrated downstream annotation. We identified 58,696 genome-wide significant single-nucleotide polymorphisms (SNPs) condensed into 1078 independent lead variants, including 29 novel loci. Fine-mapping prioritized 317 high-confidence causal variants, encompassing key genes including BMP6, ACAN, IHH, LRP5, and SOX5. TWAS and MAGMA converged on IGF1R, FOXO3, and IRS1 as dual susceptibility genes. Pathway analysis revealed significant enrichment in endochondral ossification and growth hormone/insulin-like growth factor-1 signaling. Cell-type enrichment localized genetic risk to mesenchymal stem cells and skeletal muscle satellite cells, while spatial mapping identified cartilage primordium as the most enriched developmental context. This study systematically elucidates the shared genetic architecture of osteosarcopenia, highlighting developmental, endocrine, and stem cell-related pathways as core mediators. These findings provide a theoretical foundation for precision geroscience and the development of dual-target therapeutic strategies. - Source: PubMed
Publication date: 2026/05/21
Lai WeiqiangGong KaiqinZhong RonghaoYin WeicongLi XuHe XinhuangHu SiyuanChen ChuqunHe KunruiSun ChunhanZheng JianpingZeng Guowei - This study aimed to develop a rapid, high-sensitive, and accurate amplified luminescent proximity homogeneous assay (AlphaLISA) for measuring plasma concentrations of growth differentiation factor 15 (GDF15) and assessing its application value in the diagnosis of cardiovascular disease (CVD). - Source: PubMed
Publication date: 2026/05/21
Tian NannanChen MeichunZhang SongzhaoWang JunhongHuang BiaoKao ShangbinZheng TianyuQin YuanZhao XueqinZhang ZhirongZhou Xiumei - Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic disorders with relapsing and remitting disease courses. Several clinical indicators and biomarkers have been evaluated for their clinical utility in assessing disease prognosis and monitoring disease activity. This study evaluated the utility of growth differentiation factor-15 (GDF15) and bone morphogenetic protein-6 (BMP6) in inflammatory pathways and iron regulation in IBD. - Source: PubMed
Publication date: 2026/05/19
Üstün YusufYanık SinanUçar FatmaÜstün Ahmet YalçınErdal HarunCoşkun YusufYüksel İlhami - Ovarian cancer (OC) is a highly aggressive malignancy with poor prognosis and limited response to immunotherapy. Ribosomal stress, a cellular response to disrupted ribosome biogenesis, has been increasingly implicated in tumorigenesis and immune regulation, yet its contribution to OC remains unclear. - Source: PubMed
Publication date: 2026/05/11
Han XuechuanYu YanFan YangZhang Miao - The Fukushima nuclear accident highlighted that evacuation-related psychosocial harm can outweigh direct radiation risks, underscoring the need to define the health impacts of chronic low-dose-rate (LDR) radiation and evidence-based thresholds for intervention. This study investigated the effects of continuous, postnatal LDR gamma irradiation (1.2 mGy/h, cumulative dose: 5 Gy) in male mice. While no changes in body weight, hippocampal neurogenesis, or major glial and neuronal populations were observed, persistent DNA damage (γ-H2AX foci) in dentate gyrus granule cells occurred in both irradiated male and female mice. Irradiated male mice developed anxiety-like behaviour, a phenotype not observed in a previously published study of female mice subjected to an identical irradiation protocol. Molecular profiling revealed two novel, dysregulated miRNA/mRNA axes in the hippocampus linking DNA damage to behaviour: a maladaptive miR-466i-5p/Tfcp2l1 pathway associated with genomic instability, and a potentially adaptive miR-101a-5p/BMP6 pathway promoting neuronal survival. Venn analysis further identified miR-124b-3p and novel-miR489-3p as conserved exposure biomarkers, altered in both the hippocampus and blood of irradiated animals. Our results show that a high cumulative dose of chronic LDR induces markedly less severe hippocampal pathology than has been reported for equivalent acute doses. These findings support the concept of dose-rate-dependent threshold dose and contribute to the evidence base for developing countermeasures following nuclear incidents or other radiation exposures. - Source: PubMed
Publication date: 2026/04/17
Tang Feng RuWang HongLau SalihahTan Amanda