Human Brevican ELISA , BCAN
- Known as:
- Human Brevican Enzyme-linked immunosorbent assay test , BCAN
- Catalog number:
- E01B0380
- Product Quantity:
- 96 Tests/kit
- Category:
- -
- Supplier:
- BGene
- Gene target:
- Human Brevican ELISA BCAN
Related genes to: Human Brevican ELISA , BCAN
- Gene:
- BCAN NIH gene
- Name:
- brevican
- Previous symbol:
- -
- Synonyms:
- BEHAB, MGC13038, CSPG7
- Chromosome:
- 1q23.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-03-01
- Date modifiied:
- 2016-10-05
Related products to: Human Brevican ELISA , BCAN
Related articles to: Human Brevican ELISA , BCAN
- Major depressive disorder (MDD) is the leading cause of disability worldwide and shows marked sex differences in prevalence and symptomatology. The dorsolateral prefrontal cortex (DLPFC) and hippocampus are key regions implicated in MDD, yet the role of extracellular matrix (ECM) dysregulation in these areas remains unclear. The ECM supports neural plasticity and synaptic stability through chondroitin sulfate proteoglycans (CSPGs), remodeling enzymes, and adhesion molecules, and its disruption has been linked to psychiatric disorders. In this study, we examined postmortem DLPFC and hippocampal tissue from 20 individuals with MDD and 20 controls to assess expression of ECM-related genes (BCAN, NCAN, VCAN, ADAMTS1, ADAMTS8, CSGALNACT1, SEMA3A, TNR, ST8SIA4). Protein levels of ADAMTS8, SEMA3A, and ST8SIA4 were further examined by Western blotting. We observed that ADAMTS8 expression was significantly reduced in the DLPFC of individuals with MDD, indicating potential impairments in ECM remodeling. Sex-stratified analyses revealed decreased SEMA3A expression in males with MDD and a trend toward reduced ST8SIA4 expression in females. At the protein level, SEMA3A was increased in the DLPFC but decreased in the hippocampus when both sexes were analyzed together, suggesting region-specific or post-transcriptional regulation. Notably, SEMA3A protein levels were significantly increased in males within the DLPFC, with a trend toward decrease in males in the hippocampus. ST8SIA4 protein expression was also reduced in the DLPFC in MDD. These findings identify alterations in ECM-related gene and protein expression in MDD, supporting a role for impaired ECM remodeling and synaptic plasticity in the disorder and highlighting the ECM as a promising therapeutic target. - Source: PubMed
Publication date: 2026/06/02
Klimczak PRivero OMolto M DUnzueta-Larrinaga PAlcaide JGramuntell YMorentin BUrigüen LCallado L FNacher J - The construction of high-performance polymers from sustainable resources represents a forefront direction in materials science. Dynamic covalent chemistry can introduce recyclability into bio-based cross-linked polymers, yet a trade-off between their mechanical robustness and reprocessability often persists. Herein, we report a synergistic integration of biomass feedstocks, dynamic covalent bonds, and mechanically interlocked architectures to create bio-based covalent adaptable oligorotaxane networks (BCANs), seamlessly combining mechanical robustness, biomass-derived sustainability, and circular reprocessability. These networks form through catalyst-free reactions between epoxidized soybean oil and the topologically engineered polyrotaxane. Benefiting from unique force-responsive behaviors of the polyrotaxanes, representative BCAN-3 exhibits exceptional mechanical properties with significantly enhanced Young's modulus (42 vs. 7.0 MPa), maximum stress (8.6 vs. 2.3 MPa), fracture strain (234% vs. 89%), and toughness (12.6 vs. 1.2 MJ/m) compared to control whose wheels are nonslidable under applied force. Furthermore, the incorporated β-hydroxy ester linkages enable dynamic transesterification under mild conditions, allowing the material to be efficiently reprocessed multiple times at 110°C while completely retaining its structural integrity and mechanical performance. This strategy bridges biomass-derived platforms and mechanically interlocked architectures, opening a pathway to sustainable polymers with robust mechanical properties, extended durability, and end-of-life recyclability. - Source: PubMed
Publication date: 2026/05/21
Wang WenbinBai RuixueGao WenzheYu WeiZhang ZhaomingYan Xuzhou - Bromochloroacetonitrile (BCAN) is a halogenated nitrogenous disinfection byproduct (N-DBP) frequently detected in chlorinated swimming pools. While its cytotoxicity has been established in various mammalian cells, its dermal and vascular impacts remain poorly understood. This study evaluated the cytotoxic, oxidative, and regenerative responses of human keratinocytes (HaCaT) and vascular endothelial cells (HUVECs) to BCAN exposure in vitro. BCAN significantly reduced HaCaT viability in a concentration- and time-dependent manner, with an IC of ∼42 μM at 48 h. Increased lactate dehydrogenase (LDH) release and reactive oxygen species (ROS) generation confirmed membrane damage and oxidative stress. In contrast, HUVECs maintained viability and membrane integrity at all concentrations except 80 μM, indicating higher cellular resilience. Representative scratch and tube formation assays suggested that keratinocyte migration and endothelial angiogenic behavior were largely preserved, with only moderate impairment at cytotoxic concentrations. These findings highlight the selective sensitivity of skin cells to BCAN and suggest that short-term BCAN exposure may have limited effects on wound closure- and angiogenesis-related responses under the present experimental conditions. The results underscore the importance of evaluating regenerative end points in the risk assessment of unregulated DBPs in recreational waters. - Source: PubMed
Publication date: 2026/04/29
Fayadoglu ElifFayadoglu MustafaBarutca BanuKoparal A TansuKoparal A Savas - Breast cancer rates are increasing globally amongst premenopausal women, who often face aggressive subtypes with poorer outcomes than postmenopausal women. In the United Kingdom, current guidelines for risk assessment amongst women under age 50 years focus on family history or genetic predisposition, a strategy that fails to identify most women that go on to develop breast cancer. The Breast CANcer Risk Assessment in Younger women (BCAN-RAY) study is evaluating the feasibility and acceptability of a novel risk assessment strategy for women aged 30-39 years, without a strong family history, incorporating a risk factor questionnaire, polygenic risk score and breast density assessment to identify those at increased risk and support early screening and preventive health measures. - Source: PubMed
Publication date: 2026/04/24
Horton RosieHindmarch SarahHowell Sacha JUsher-Smith Juliet AGorman LouiseEvans D GarethFrench David P - Accurate electrode placement and individual stimulation parameters influence the outcomes of subthalamic deep brain stimulation in Parkinson's disease. Neuroimaging-based models can help evaluate how electrode placement impacts improvement, aiming to reduce the burden of programming. However, most existing models have been developed to explain differences between patients rather than differences between contacts within the same patient, leaving the clinical relevance of image-guided programming unclear. - Source: PubMed
Publication date: 2026/04/17
Zvarova Patriciavan der Linden ChristinaLi NingfeiButenko KonstantinBerger TheaMeyer Garance MSahin Ilkem AysuGoede Lukas LBahners Bahne HHollunder BarbaraDembek Till APines Andrew RReich MartinVolkmann JensOdekerken Vincent J Jde Bie Rob M AXu XinLing ZhipeiYao ChenKühn Andrea ASoekadar Surjo RRitter KerstinBarbe Michael TVisser-Vandewalle VeerleFox Michael DPetry-Schmelzer Jan NiklasRajamani NandithaHorn Andreas