Human Apolipoprotein A4 ELISA , APOA4
- Known as:
- Human Apolipoprotein A4 Enzyme-linked immunosorbent assay test , APOA4
- Catalog number:
- E01A0511
- Product Quantity:
- 96 Tests/kit
- Category:
- -
- Supplier:
- BGene
- Gene target:
- Human Apolipoprotein A4 ELISA APOA4
Related genes to: Human Apolipoprotein A4 ELISA , APOA4
- Gene:
- APOA4 NIH gene
- Name:
- apolipoprotein A4
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 11q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-04-26
Related products to: Human Apolipoprotein A4 ELISA , APOA4
Related articles to: Human Apolipoprotein A4 ELISA , APOA4
- Renal transplant patients (RTPs) receiving immunomodulatory therapy are at increased risk of severe complications from COVID-19 and other infections. This study aimed to identify immune and proteomic biomarkers associated with COVID-19 in RTPs to improve disease characterization and support future diagnostic and therapeutic strategies. - Source: PubMed
Publication date: 2026/06/12
Alaiya AyodeleAl-Mozaini MahaShinwari ZakiaAlzayed AbdulazizAlsharif IbtihajAllam RababBakheet RazanAlharbi LaylaAlotaibi Fahad OjabIdris JumanaObeid Dalia AAlshukairi AbeerMárquez-Méndez MarcelaCerda-Flores Ricardo MAlmojalli Hamad A - Risk stratification in diabetic kidney disease is challenging. Identifying nodular diabetic nephropathy (NDN), the most specific histological feature of diabetic nephropathy (DN), associated with poor prognosis, currently requires kidney biopsy. We aimed to identify urinary peptide biomarkers distinguishing NDN from other chronic kidney disease etiologies in diabetes (nNDN). - Source: PubMed
Publication date: 2026/06/26
Kondyli MargaritaSiwy JustynaJaimes Campos Mayra AlejandraAmann KerstinBeige JoachimKeller FelixMischak HaraldFrantzi MariaWendt RalphRossing PeterRupprecht HaraldCatanese LorenzoJankowski Vera - Seminal plasma can have wide-ranging effects on reproductive fitness-from affecting sperm fertilization capacity and female reproductive physiology to influencing offspring viability and health. Seminal plasma can also change in response to environmental conditions including diet, which of itself is known to affect reproductive traits and fitness outcomes. However, an understanding of how paternal diet alters seminal plasma composition and how these effects relate to fetal development remains elusive. Here, we applied the geometric framework for nutrition to systematically manipulate dietary macronutrient balance in male mice and determine dietary effects on the seminal vesicle fluid (SVF; comprising much of the seminal plasma) proteome, as well as relate differences in the proteome to aspects of fetal development. We (i) identified the largest number of proteins in the mouse SVF proteome to date, (ii) determined a set of proteins that were significantly affected by dietary macronutrients, (iii) showed that differences in a protein related to lipid mobilization and metabolism (APOA4) were correlated with fetal development, and (iv) detected dietary effects on aspects of fetal development that were unrelated to SVF protein abundance. This study provides a comprehensive characterization of the male SVF proteome across nutritional space and highlights potential functional ways in which male diet and the seminal plasma may mediate fitness. - Source: PubMed
Macartney Erin LSenior Alistair MSmall LewinCrean Angela JPini TaylorPulpitel Tamara JNobrega Marcelo ABarrès RomainSimpson Stephen J - One of the major pathways to clear glycoproteins from circulation is via the liver-specific asialoglycoprotein receptor (ASGPR). Loss of asialoglycoprotein receptor 1 (ASGR1), the major subunit of ASGPR in humans, was found to correlate with lower levels of plasma apolipoprotein B-containing lipoproteins (B-lps) and a profound reduction in cardiovascular disease risk. However, the cell and molecular biology underlying this effect was unclear. Given that rodents carry their cholesterol largely in HDL, we selected the zebrafish model to better understand the mechanism(s) of action of ASGR1. We first characterized all possible zebrafish ASGR1 orthologs to identify zebrafish ASGR1 (asgr1a) from a collection of lectin-binding proteins. We then generated two independent mutations in asgr1a using CRISPR/Cas9. Neither mutation altered larval, juvenile, or adult B-lp numbers or sizes. However, when challenged with a Western Diet, asgr1a mutant zebrafish exhibited less hepatic steatosis and lower hepatic triglyceride levels compared to control animals. Asgr1a mutant animals also exhibited increased levels of fecal cholesterol, due to attenuated post-prandial absorption and upregulation of liver proteins known to be involved in B-lp metabolism (e.g. Mttp, ApoA4). These data are consistent with the atheroprotective role of ASGR1 and reveal a previously unappreciated role for ASGR1 in modulating whole animal cholesterol flux. - Source: PubMed
Publication date: 2026/06/09
Derrick Joshua TMoll Tabea O CSweeney Darby WShin JeffreySvecla MonikaNorata Giuseppe DaniloFarber Steven A - Cannabidiol (CBD) is increasingly being used in veterinary medicine; however, its systemic molecular effects in dogs remain poorly characterized. This study employed label-free quantitative proteomics to compare the serum proteomic responses of healthy dogs ( = 18) after 30 days of oral CBD delivery via three distinct matrices: hemp by-product feed pellets (F), CBD-infused oil (O), and semi-solid treat (SN). The verified chronic doses differed among the groups. Multivariate analysis revealed distinct formulation-specific proteomic signatures, with the F group clustered separately from the O and SN groups. Despite dose and matrix variations, all groups shared a core metabolic response characterized by downregulation of apolipoproteins (APOA4, APOC3, APOC1, and APOH) and upregulation of hemoglobin subunits (HBA and HBB), indicating CBD-mediated modulation of lipid metabolism and redox homeostasis. The high-exposure groups (O, SN) uniquely exhibited upregulation of proteins involved in vascular integrity and tissue scaffolding (e.g., TGFB1, PDGFRB, and VWF), while the SN group also showed induction of immunomodulatory and cytoprotective markers, such as clusterin (CLU). These findings demonstrate that the CBD delivery matrix critically influences systemic bioavailability and the scope of proteomic remodeling. Although all formulations engage core metabolic pathways, high-bioavailability formats induce additional signatures suggestive of vascular stabilization and stress resilience, providing a molecular rationale for optimizing CBD-based therapeutic formulations in canine medicine. - Source: PubMed
Publication date: 2026/05/13
Theerapan WutthiwongLimsuwan SasithornRattanasrisomporn JatupornPloypetch SekkarinTansakul Natthasit