Human Adenylate Cyclase 4 ELISA , ADCY4
- Known as:
- Human Adenylate Cyclase 4 Enzyme-linked immunosorbent assay test , ADCY4
- Catalog number:
- E01A0489
- Product Quantity:
- 96 Tests/kit
- Category:
- -
- Supplier:
- BGene
- Gene target:
- Human Adenylate Cyclase 4 ELISA ADCY4
Related genes to: Human Adenylate Cyclase 4 ELISA , ADCY4
- Gene:
- ADCY4 NIH gene
- Name:
- adenylate cyclase 4
- Previous symbol:
- -
- Synonyms:
- AC4
- Chromosome:
- 14q12
- Locus Type:
- gene with protein product
- Date approved:
- 1994-07-22
- Date modifiied:
- 2016-10-05
Related products to: Human Adenylate Cyclase 4 ELISA , ADCY4
Related articles to: Human Adenylate Cyclase 4 ELISA , ADCY4
- Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer (NSCLC) and remains a leading cause of cancer-related mortality. However, the functional role and regulatory mechanism of adenylate cyclase 4 () in LUAD progression are not fully understood. Therefore, this study aimed to systematically explore the expression pattern, prognostic value, and biological function of in LUAD, and to elucidate its potential regulatory mechanism through interaction with protein kinase C beta (). - Source: PubMed
Publication date: 2026/07/24
Wang JieyangZheng ChaojingShen WeiChen QianshunLin YuyuHuang ShuweiGao LeiHuang Chen - Nasopharyngeal carcinoma (NPC) is a malignant tumor of the nasopharyngeal mucosal epithelium. The aryl hydrocarbon receptor (AhR)-a widely distributed nuclear receptor regulating adaptive adverse responses-is confirmed carcinogenic upon activation. Thus, this study aims to identify novel biomarkers for NPC treatment. - Source: PubMed
Publication date: 2026/07/27
Liang QiulinCao ChangxingZou ZilingPeng YulanFeng Chao - Endothelial dysfunction is critical for the pathogenesis of atherosclerosis, particularly in arterial regions exposed to disturbed flow (DF). ADCY4 (adenylate cyclase 4) catalyzes the production of cAMP, a ubiquitous second messenger that regulates cellular and physiological processes. This study investigated ADCY4 as a shear-stress-responsive gene in ECs for the regulation of vascular endothelial inflammation during atherogenesis. - Source: PubMed
Publication date: 2026/08/06
Bao WenzhenXu JianfeiNian WenjianPang PeilinWu WenrunHuang ZijianHu LinLi HongdaPan WenqiGao XiaotongHu WeilinQu LefengZhang LinChen XiaoliLiu JieZhang Yuzhen - S-palmitoylation, a reversible lipid-based post-translational modification, is notably elevated in colorectal cancer (CRC) due to common lipid metabolism disorders. It has been reported to play crucial roles in regulating membrane composition, cell proliferation, and metastasis in various malignancies such as pancreatic and breast cancers. However, its role in the progression of CRC remains poorly understood. ZDHHC9, a member of the palmitoyl transferase family, is significantly upregulated in CRC patients and correlates with poor prognosis. Knockdown of ZDHHC9 impairs CRC cell proliferation and migration both in vitro and in vivo. RNA sequencing revealed that ZDHHC9 depletion markedly downregulates the cAMP signaling pathway. Mechanistically, ZDHHC9 knockdown impairs ADCY4 activity by reducing S-palmitoylation of KLF5 at cysteine 438, thereby modulating the ZDHHC9/KLF5/ADCY4 axis and downstream cAMP/PKA/CREB signaling to influence CRC cell proliferation and migration. Our findings demonstrate that ZDHHC9 promotes CRC progression by regulating intracellular cAMP levels through KLF5 palmitoylation, providing a novel therapeutic perspective targeting palmitoylation in CRC. The mechanism diagram of this study. ZDHHC9 mediates palmitoylation of KLF5 at cysteine 438, thereby enhancing ADCY4 activity and increasing intracellular cAMP levels. This elevation in cAMP promotes PKA and phosphorylation of CREB, ultimately activating the cAMP/PKA/CREB signaling pathway, which contributes to the regulation of CRC cell proliferation, migration, and resistance to 5-FU. (Created with BioRender.com). - Source: PubMed
Publication date: 2026/03/25
Zhang HaoTian YuanXiang ZeyuHan FengChen MiaomiaoJiang ChunhuiLiu YeXue HanbingHu LipengXu ChunjieGu LeiXu Qing - Adenylate cyclase 4 (ADCY4), a member of the adenylate cyclase family, is an enzyme responsible for catalyzing the synthesis of the secondary messenger cyclic adenosine monophosphate (cAMP). Emerging evidence suggests a potential link between ADCY4 expression and the prognosis as well as biological behaviors of specific malignancies. Nevertheless, a systematic investigation into the role of ADCY4 in pan-cancer prognosis and its regulatory influence on the tumor microenvironment remains insufficient. - Source: PubMed
Publication date: 2026/03/17
Yu CuiFang LiuMeijuan CaiYuanli WangMin Fang