Human Attractin ELISA , ATRN
- Known as:
- Human Attractin Enzyme-linked immunosorbent assay test , ATRN
- Catalog number:
- E01A0006
- Product Quantity:
- 96 Tests/kit
- Category:
- -
- Supplier:
- BGene
- Gene target:
- Human Attractin ELISA ATRN
Related genes to: Human Attractin ELISA , ATRN
- Gene:
- ATRN NIH gene
- Name:
- attractin
- Previous symbol:
- -
- Synonyms:
- DPPT-L, MGCA
- Chromosome:
- 20p13
- Locus Type:
- gene with protein product
- Date approved:
- 1998-10-30
- Date modifiied:
- 2015-08-26
Related products to: Human Attractin ELISA , ATRN
Related articles to: Human Attractin ELISA , ATRN
- Turbot () is a key farmed flatfish species in North China, where growth performance directly determines aquaculture profitability. To elucidate the genetic architecture underlying growth traits, we performed whole-genome resequencing of 177 turbot individuals and obtained 5.29 million high-quality single nucleotide polymorphisms (SNPs). Genome-wide association studies (GWAS) were conducted for eleven growth traits-body weight (BW), total length (TL), body length (BL), body depth (BD), trunk length (TUL), head length (HL), snout length (SnL), caudal peduncle depth (CPD), eye diameter (ED), post-orbital head length (PoL), and interorbital width (IW)-using both single-trait and multi-trait approaches. Heritability estimates ranged from 0.001 (IW) to 0.259 (BW), with BW showing the highest heritability, and genetic correlation analysis revealed strong positive correlations between BW and most body size traits ( > 0.7). Critically, extensive genetic pleiotropy governing these traits was uncovered. In single-trait GWAS, two pleiotropic loci-19:16017254 (within ) and 15:2921091 (within )-were repeatedly associated with the same six body-size traits (BD, BL, CPD, HL, TL, and TUL), demonstrating that single variants can exert coordinated effects across multiple morphological dimensions. Furthermore, multi-trait GWAS captured additional pleiotropic signals that remained undetected in single-trait analyses, identifying 20 novel loci encompassing key candidates such as (cytoskeletal signaling), (actin organization). KEGG enrichment further consolidated these findings, with candidate genes significantly enriched in the "Regulation of actin cytoskeleton" pathway, while emerged as a hub gene integrating three metabolic pathways. Collectively, these results highlight the pervasive pleiotropy underlying turbot growth and serve as promising candidate loci for marker-assisted selection, although independent validation in larger populations is required before practical application. - Source: PubMed
Publication date: 2026/07/27
Chen AoLiang ShuoJiang Li - Hepatolithiasis (HL) is a prevalent condition in hepatobiliary surgery, often complicated by hepatatrophia. This study aimed to identify gene mutations in HL specimens with hepatatrophia and construct a mutation landscape using whole-exome sequencing (WES). - Source: PubMed
Publication date: 2026/04/09
Tang DanGu XuanyuLiu DanYang JialiZhao Lijin - To explore systemic contributors to central serous chorioretinopathy (CSCR) pathogenesis, we performed untargeted serum proteomics in 60 male CSCR patients (30 acute, 30 chronic) and 60 age-matched controls using label-free LC-MS/MS with stringent statistical pairing. Among 242 abundant proteins identified, 27 (11.5%) were significantly different in CSCR, converging on pathways of complement activation, coagulation, oxidative stress, immune regulation, and response to external stimuli. Complement cascade components (C1QA, C1S, C3, C4B, C8A/B/G, CFB) were upregulated, while the regulators CFHR1 and CFHR2 were decreased, contrary to age-related macular degeneration. Oxidative stress-related proteins (haptoglobin, hemoglobin subunits, peroxiredoxin-2) were elevated, consistent with prior evidence of systemic redox imbalance in CSCR. Tetranectin (CLEC3B) decreased and attractin (ATRN) increased in CSCR were validated by ELISA. Multiplex immunofluorescence on the human retina localized tetranectin to Müller cells, including the outer limiting membrane, and to the RPE and attractin to photoreceptor segments, retinal pigment epithelium, Bruch's membrane, and the choriocapillaris, supporting potential roles of both proteins at the retina-choroid interface. A distinct systemic proteomic signature in patients with CSCR highlights complement dysregulation, oxidative stress, and stress responses to external stimuli and identifies tetranectin and attractin as candidate biomarkers, which should further be validated in other cohorts. - Source: PubMed
Publication date: 2026/02/05
Chambon ChristophePicard EmilieZola MartaAichedo SeikiLebon CécileYouale JennyMatet AlexandreBousquet ElodieFerreira ClaudeKowalczuk LauraThéron LaetitiaBehar-Cohen Francine - The differential diagnosis between Tuberculosis (TB) and Non-tuberculous Mycobacteria (NTM) has historically been constrained by the inadequate sensitivity and specificity of current diagnostic methods. Furthermore, distinguishing between Active Tuberculosis (ATB) and Latent Tuberculosis Infection (LTBI) poses significant challenges. This study aims to develop a molecular differentiation system for ATB, LTBI, and NTM by integrating plasma proteomics with multi-dimensional analytical techniques, while also exploring key biomarkers associated with disease progression and treatment response. - Source: PubMed
Publication date: 2025/12/22
Hu YanQuan ChaoZhou YuanyuanLiang ShangyanWang XuanLi JunLiu WenqiXu YuzhongLiu Peng - Although bacterial genomes encode numerous potential toxins, it is unclear how evolution drives the specificity of these important virulence factors. Using an insect CRISPR screen, we identified the transmembrane protein Attractin (ATRN) as the receptor for Nigritoxin (Ntx), a Vibrio toxin that causes seasonal shrimp pandemics. We found that Ntx's effector "warhead" inhibits translation via a previously uncharacterized mechanism. Moreover, we show that two related toxins require ATRN for entry but possess unrelated effector domains. One has a Rho-GTPase AMPylation function and the other an actin-targeting/proteolysis function. Our findings reveal the mechanism of Ntx entry and toxicity and show that the ATRN-targeting domain can deliver disparate effector domains, strongly indicating that this class of exotoxins can evolve as modular proteins using a common entry domain. - Source: PubMed
Publication date: 2025/10/11
Viswanatha RaghuvirLee DonghoonRobins William RMameli EnzoHu YanhuiKim Ah-RamHashmi YousufNishida HiroshiPrakash GyanButnaru MatthewChurchman SterlingMohr Stephanie EMekalanos John JPerrimon Norbert