SERPINA3 predesign siRNA
- Known as:
- SERPINA3 predesign small interfearing RNA
- Catalog number:
- RI14776
- Category:
- -
- Supplier:
- Abgen
- Gene target:
- SERPINA3 predesign siRNA
Related genes to: SERPINA3 predesign siRNA
- Gene:
- SERPINA3 NIH gene
- Name:
- serpin family A member 3
- Previous symbol:
- AACT
- Synonyms:
- ACT
- Chromosome:
- 14q32.13
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-10-04
Related products to: SERPINA3 predesign siRNA
Related articles to: SERPINA3 predesign siRNA
- To examine the main adverse cardiovascular events that occur in individuals who have had an acute ST-segment elevation myocardial infarction (STEMI) after receiving percutaneous coronary intervention (PCI), such as serum C-type lectin domain family member 2 (CLEC2), serine protease inhibitor family member A3 (SERPINA3), and high-sensitivity C-reactive protein/albumin (hs-CRP/ALB) levels. - Source: PubMed
Ma YuncongFang SuxiaLiu ShashaJiang Zhencong - The molecular mechanisms linking vascular aging (VA) and heart failure (HF) remain elusive, hindering therapeutic strategies for their comorbidity. This study aimed to identify key biomarkers and pathways potentially involved in VA-HF synergy using integrative computational approaches. - Source: PubMed
Publication date: 2026/09/15
Li JinzeZhou GuitingWang QiaochuSong ZhixuanLiu JiantaoShen ChangzaoLuo ChuanjinWang Dawei - Rheumatoid Arthritis (RA) is a Prevalent Autoimmune Disorder Affecting Millions of People Worldwide. A Thorough Understanding of Its Clinical and Pathological Features Is Essential to Improve Patient Outcomes. - Source: PubMed
Zhao YangLi YuanQi MengXu JunhuaJi FengweiKan YanKong Chunyu - Cardiac fibrosis is a central driver of adverse remodeling and heart failure (HF), yet effective antifibrotic therapies remain limited. SerpinA3, a member of the serine protease inhibitor family, has been implicated in cardiovascular disease, but its functional role and underlying mechanisms in cardiac remodeling are poorly defined. - Source: PubMed
Publication date: 2026/08/30
Wang HuiCui JieyuHuang ChunluGuo WanyiLiu TongZhu YiShao ShuaiChen KangyinHe JinlongBao Qiankun - Diagnostic evaluation of suspected neuromyelitis optica spectrum disorder (NMOSD) integrates AQP4-IgG testing, clinical assessment, neuroimaging, and exclusion of alternative inflammatory demyelinating disorders; nevertheless, some patients remain diagnostically unresolved or may be misclassified as multiple sclerosis (MS) or other disorders. This single-center retrospective exploratory study analyzed quantitative serum proteomics from 20 patients with MS and 20 with NMOSD. Proteins meeting nominal < 0.05 together with prespecified fold-change criteria were considered exploratory candidates. VWF, PPBP, and SERPINA3 were subsequently assessed by ELISA in a separate, non-overlapping cohort from the same center, together with routine hematological variables. Among 261 protein entries, 34 met the exploratory nominal threshold and fold-change criteria, but none remained significant after Benjamini-Hochberg correction (lowest q = 0.0734). VWF and PPBP showed no significant differences across the four validation groups. SERPINA3 differed across groups (Kruskal-Wallis H = 44.982, = 9.34 × 10) and was higher in NMOSD than in MS, TBI, and HCs after Holm adjustment (adjusted = 0.036, 1.49 × 10, and 1.13 × 10, respectively). In the full ELISA cohort, the AUC was 0.928 for NMOSD versus HC and 0.800 for NMOSD versus MS. In a post hoc sensitivity analysis excluding participants with preceding infection, the NMOSD-MS separation was attenuated. In smaller complete-case analyses, adding an additional laboratory variable to SERPINA3 did not significantly improve apparent discrimination. SERPINA3 is therefore an exploratory adjunctive serum biomarker candidate rather than a stand-alone diagnostic test; prospective external validation in clinically representative cohorts is required. - Source: PubMed
Publication date: 2026/08/20
Xu TingHan BingqingZheng GuanghuiJiang WencanZhang HanyuZhang Guojun