S100A9 predesign siRNA
- Known as:
- S100A9 predesign small interfearing RNA
- Catalog number:
- RI14689
- Category:
- -
- Supplier:
- Abgen
- Gene target:
- S100A9 predesign siRNA
Related genes to: S100A9 predesign siRNA
- Gene:
- S100A9 NIH gene
- Name:
- S100 calcium binding protein A9
- Previous symbol:
- CAGB, CFAG
- Synonyms:
- P14, MIF, NIF, LIAG, MRP14, MAC387, 60B8AG, CGLB
- Chromosome:
- 1q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 1989-05-19
- Date modifiied:
- 2018-05-02
Related products to: S100A9 predesign siRNA
Related articles to: S100A9 predesign siRNA
- Bullous pemphigoid and atopic dermatitis are both inflammatory skin disorders characterized by intense pruritus and type 2 immune responses. Previous studies identified and as highly upregulated genes in perilesional skin of both conditions. Here, we demonstrate that S100A8/9 is highly expressed in the keratinocytes and infiltrating immune cells in bullous pemphigoid and atopic dermatitis skin and elevated in the serum of patients with bullous pemphigoid. Notably, infiltrating neutrophils in the perilesional skin, one of the major sources of secreted S100A8/9, are in close proximity to the cutaneous nerves, suggesting neuroimmune interactions. Using calcium imaging analysis, we show that S100A8/9 directly excite nociceptive sensory neurons in a toll-like receptor 4-dependent manner. Toll-like receptor 4 is expressed in a unique subset of nociceptive neurons that co-express histamine receptor H1. Intriguingly, mouse behavioral analyses reveal that S100A8/9 potentiates histamine-evoked scratching. Together, these results suggest S100A8/9 as a shared neuroimmune amplifier of histaminergic itch in T helper 2-driven dermatoses. - Source: PubMed
Publication date: 2026/03/20
Lawson KatyNho YeseulStewart RyanWu ShuangCole Emily FHerrera DanielChisolm SarahFeldman RonHan Liang - Objective To explore the effect and mechanism of aqueous extract of Euphorbia helioscopia L. (EHE) on improving the immune environment and inhibiting lung tumor nodules induced by lipopolysaccharide (LPS) combined with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in mice. Methods Male BALB/c mice were randomly divided into 6 groups: normal group, model group, Euphorbia helioscopia water extract low-, medium-, and high-dose groups (0.9, 1.8, 3.6 g/kg), and aspirin group (20 mg/kg). Samples were collected after 25 weeks. HE and immunohistochemistry staining were used to detect tumor lesions in lung tissues. Western blot was performed to determine the expression of oncoproteins in lung tissues. Real-time fluorescence quantitative PCR and flow cytometry were employed to detect the mRNA levels of immune-related molecule genes and the percentage of immune cells in lung tissues, respectively. Additionally, Western blot was used to detect the expression of proteins related to immune regulatory pathways. Results HE and immunohistochemistry staining revealed that LPS combined with NNK induced the formation of adenomatous tumor nodules in mice, with high expression of thyroid transcription factor 1 (TTF-1) in the lungs. Compared with the model group, the Euphorbia helioscopia-treated groups exhibited a significant reduction in the number of lung tumor nodules, decreased expression of the oncoprotein c-Myc and anti-apoptotic protein Bcl2, and increased expression of the pro-apoptotic protein BAX. The mRNA levels of immune-related molecules in lung tissues, including S100 calcium-binding protein A9 (S100A9), cyclooxygenase 2 (COX2), granulocyte-macrophage colony-stimulating factor (GM-CSF), chemokine ligand 1 (CXCL1), monocyte chemoattractant protein 1 (MCP-1), interleukin 10 (IL-10), and IL-4, were significantly downregulated. In lung tissues, the percentage of macrophages increased, while the percentage of myeloid-derived suppressor cells (MDSCs) decreased. In the spleen, the percentages of regulatory T cells (Tregs) and MDSCs were reduced. The protein expression levels of programmed death ligand 1 (PD-L1), cluster of differentiation 47 (CD47), phosphorylated nuclear factor κB p65 subunit (p-NF-κB p65), and phosphorylated signal transducer and activator of transcription 3 (p-STAT3) were decreased. Conclusion The aqueous extract of Euphorbia helioscopia L. can effectively inhibit LPS/NNK-induced formation of lung adenoma nodules by improving the immune environment, and its mechanism may involve regulating the activation of NF-κB and STAT3. - Source: PubMed
Jin XuhuiDuan WenbinChen LanyingHuang YuqingChen YajuanLiu Ronghua - Antimicrobial peptides (AMPs) are essential components of the innate immune system, exhibiting diverse mechanisms of action. - Source: PubMed
Pinheiro da Silva FabianoSoriano Francisco GarciaHajjar Ludhmila Abrahão - Psoriasis, a chronic inflammatory skin disease affecting 2-3% of the global population, is driven by dysregulated immune responses. Despite advancements in biologic therapies, treatment challenges persist due to high recurrence rates. This study aimed to identify immune-related hub genes and elucidate their clinical implications in psoriasis pathogenesis and therapy. - Source: PubMed
Publication date: 2026/04/20
Sun YuzhenZhou ZiguangMao YuLiu NiuLi YanfengFang Weiyuan - Type 1 diabetes mellitus (T1DM) compromises the mechanical adaptive capacity of bones, posing challenges in orthodontic treatment and increases periodontal complication risks. Mechanical loading is the main inducer of craniofacial bone adaptation; however, the early proteomic responses of the maxillary bone to stress under diabetic conditions remain unexplored. Therefore, we aimed to characterize the early proteomic signatures of the maxillary bone in T1DM rats subjected to controlled mechanical stress and identify potentially relevant molecular pathways for orthodontic treatment in patients with diabetes. - Source: PubMed
Publication date: 2026/04/06
Tobias-López Luis FernandoTrejo-Iriarte Cynthia GeorginaGarcía-Muñoz AlejandroGómez-Clavel José Francisco