NIPA2 predesign siRNA
- Known as:
- NIPA2 predesign small interfearing RNA
- Catalog number:
- RI13593
- Category:
- -
- Supplier:
- Abgen
- Gene target:
- NIPA2 predesign siRNA
Related genes to: NIPA2 predesign siRNA
- Gene:
- NIPA2 NIH gene
- Name:
- NIPA magnesium transporter 2
- Previous symbol:
- -
- Synonyms:
- SLC57A2
- Chromosome:
- 15q11.2
- Locus Type:
- gene with protein product
- Date approved:
- 2004-09-30
- Date modifiied:
- 2018-02-23
Related products to: NIPA2 predesign siRNA
Related articles to: NIPA2 predesign siRNA
- Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders that include deficits in social communication, maintaining relationships, and repetitive behaviors. In 25-35% of ASD cases, the genetic etiology (high-penetrance variants and copy number variations - CNVs) can be identified through whole-exome sequencing or chromosomal microarray analysis (CMA). CMA is a method dedicated to detecting submicroscopic chromosomal imbalances. The study aims to analyze CMA results in children with ASD. - Source: PubMed
Publication date: 2026/06/12
Ręka GabrielaWojciechowska KatarzynaStyka BorysJaniszewska MariolaLejman Monika - The 15q11.2 BP1-BP2 microduplication is a rare copy number variant associated with neurodevelopmental disorders, dysmorphic features, and variable expressivity. Unlike complete trisomy 15, this microduplication involves a 300 kb segment containing four genes: NIPA1, NIPA2, CYFIP1, and TUBGCP5. Few cases have been reported in sub-Saharan Africa. - Source: PubMed
Publication date: 2026/06/04
Betoko Ritha MbonoDahoun SophieNtsoli GaelleSloan-Bena FrederiqueBodieu Adele ChetchaNengom Jocelyn TonySap Suzanne - Chromosome region 15q11-q13 is prone to structural rearrangements and contains imprinted genes associated with several neurodevelopmental syndromes. In this report, we present the case of a 518 kb duplication in 15q11.2, identified prenatally through array comparative genomic hybridization. Parental testing revealed that the duplication was paternally inherited and originated from the asymptomatic paternal grandmother. The duplicated region harbored the OMIM genes , , , and , all of which presented biallelic expression and were not subjected to genomic imprinting. Given the benign familial inheritance and lack of clinical features in the father and the paternal grandmother, the duplication was considered likely to have benign significance. A healthy female newborn was delivered at term. - Source: PubMed
Publication date: 2026/02/20
Spathi Andreas ELagios StylianosPapanikolaou VassilisKostoulas CharilaosSesse AthanasiaTheochari EleniLeoutsakou TheoniPsarris AlexandrosKavvadia MariaStauroulaki TheanoDestouni AspasiaGeorgiou IoannisPampanos Andreas - Bainbridge-Ropers syndrome (BRPS, OMIM #615485) and the 15q11.2 BP1-BP2 microdeletion syndrome (OMIM #615656) are distinct genetic aetiologies of neurodevelopmental disorder Dual diagnosis of both entities in a single patient is extremely rare, and the underlying synergistic pathogenesis remains poorly understood. - Source: PubMed
Publication date: 2025/12/11
Yang MingkaiXiao YanfangChen ChanjuanChu ZhouHu Guohong - Italy hosts a rich heritage of poultry genetic resources, leading to the development of several unique native chicken breeds. Among them, the Leccese (LEC) chicken breed requires urgent genetic characterization to support conservation, development, and sustainable use. This study assessed the genetic diversity and population structure of the LEC chicken breed using the 600 K Affymetrix SNP array, comparing it with 25 Italian indigenous breeds and four commercial lines. In addition, selection signatures were explored through runs of homozygosity and integrated haplotype score analyses. The observed heterozygosity, expected heterozygosity, and minor allele frequency in LEC were 0.343, 0.358, and 0.268, respectively. The inbreeding coefficient based on observed versus expected homozygosity was 0.044, and the inbreeding coefficient based on runs of homozygosity was 0.189. Population structure analyses revealed clear genetic differentiation between the LEC and other Italian chicken breeds. Selective sweep analyses (runs of homozygosity and integrated haplotype score) identified candidate genomic regions harboring genes related to growth (GBE1, CYFIP1, NIPA2, BBOX1), bone development (PHEX), disease resistance (ROBO2, TLR7, EIF3M), and environmental adaptation (ANO5, CCDC34, HSF4, SPON1). These findings provide novel insights into the genetic background of the LEC, supporting breed identification, conservation planning, and the design of sustainable breeding programs. The identified candidate genes within selective sweep regions may serve as markers for future selection to enhance productive traits and adaptation in the LEC chicken breed. - Source: PubMed
Publication date: 2025/12/13
Saleh Medhat SRusco GiusyCendron FilippoPerini FrancescoPenasa MauroLasagna EmilianoCentoducati GerardoMaggiolino AristideCassandro MartinoCamarda AntonioDe Palo PasqualeLandi Vincenzo