ZIC4 Antibody (monoclonal) (M06)
- Known as:
- ZIC4 Antibody (mab) (M06)
- Catalog number:
- AT4582a
- Category:
- -
- Supplier:
- Abgen
- Gene target:
- ZIC4 Antibody (monoclonal) (M06)
Related genes to: ZIC4 Antibody (monoclonal) (M06)
- Gene:
- ZIC4 NIH gene
- Name:
- Zic family member 4
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 3q24
- Locus Type:
- gene with protein product
- Date approved:
- 2003-02-03
- Date modifiied:
- 2013-01-08
Related products to: ZIC4 Antibody (monoclonal) (M06)
Related articles to: ZIC4 Antibody (monoclonal) (M06)
- Dandy-Walker malformation (DWM) is a condition characterized by a cyst in the posterior cranial fossa contiguous with the fourth ventricle, combined with complete or partial agenesis of the cerebellar vermis; and elevation of the cerebellar tentorium, torcular Herophili, and transverse sinuses. DWM has been linked to specific genetic variants, with pathogenic or likely pathogenic variants reported in FOXC1, ZIC1, and ZIC4. Variants in the TUBB2B and TUBB3 genes are associated with abnormalities in tubulin, leading to cerebellar hypoplasia. In our study, three patients diagnosed with DWM underwent whole-genome analysis using next-generation sequencing, and two were found to have heterozygous variants in the tubulinopathy-associated genes TUBB2B and TUBB3, respectively. These findings indicate that some cases previously diagnosed as DWM may fall under the spectrum of tubulinopathies associated with cerebellar hypoplasia. - Source: PubMed
Publication date: 2026/06/17
Ueno KatsuyaHigasa KoichiroHayashi MikioIsozaki HarunaMiyata MayukoNaito NobuakiLi YiTakeda JunichiNonaka Masahiro - - Source: PubMed
Publication date: 2026/05/26
Ros González IChavarría-Miranda AGonzález Folgueral CPedraza Hueso M - ZIC1 encodes a transcription factor with critical roles in vertebrate neural and skeletal development. Heterozygous deletions encompassing ZIC1 and ZIC4 cause Dandy-Walker malformation, whilst in the final exon heterozygous ZIC1 variants result in a distinct phenotype of craniosynostosis with variable intellectual disability via a gain-of-function mechanism. We describe the largest group of individuals harboring ZIC1 variants to date, significantly expanding the phenotypic spectrum and allowing genotype-phenotype correlation. - Source: PubMed
Publication date: 2026/04/22
Watts Laura MChang Michelle S MLewis-Orr ElizabethWalton Isaac SLeinhos LisaTooze Rebecca SPei YangCalpena EduardoVedovato-Dos-Santos J HeatherSteel DoraReid Kimberley MKurian Manju AMohammad Shekeeb SCantagrel VincentSiquier KarineBoddaert NathalieRio MarleneBlyth MoiraKraus AlisonAl Mutairi FuadHolder Susan EClowes Virginia ECobben Jan MTimberlake Andrew TElias Ellen RStewart HelenJohnson DianaCohen Julie SBarañano Kristin WCeulemans SophiaJones Marilyn COrtega Rico Rita IHaug Marte GBerland SirenBombei Hannah MPaulson AnnaSidhu AlpaGooch Catherine Fda Rocha Kátia MPassos Bueno Maria RitaŢopa AlexandraMuslimovic Aida ZMaltese GiovanniTan Tiong YangMcCann EmmaLord HelenChin Hui-LinLin JeremyLi-Meng Goh DeniseKeren BorisCharles PerrineDelchev TrayanAvdjieva-Tzavella DanielaAlawbathani SalemAlmeida LigiaKdissa AmeniAl-Ali RuslanBertoli-Avella Aida MJohnson DavidWilkie Andrew O MArkell Ruth MShears Deborah JTwigg Stephen R F - Copy number variants (CNVs) are large-scale genomic alterations that contribute substantially to genetic diversity and may influence phenotypic variation in livestock. This study investigated the genome-wide CNV landscape of three Vietnamese indigenous chicken breeds. Whole-genome sequencing on the Illumina platform (3-5× coverage) was performed on 24 individuals from Dong Tao (DT), Cay Cum (CC), and Ri (RI) breeds. A total of 1743 CNVs were detected, clustering into 315 copy number variation regions (CNVRs). Most CNVRs were rare, with 31.7% present in only one animal among breeds. Across the genome, 122 unique CNVRs were distributed over 28 chromosomes, predominantly the first five. Losses were the most frequent type (45.9%), followed by gains (39.3%), and mixed events (14.8%). Within these CNVRs, 3633 genes were identified. In DT and RI, CNVR-embedded genes included several candidates, potentially related to adaptability, development, and phenotypic diversification. Notably, DT harbored genes such as , , , (adaptation, stress/immune response) and , , , , , , , and (developmental and skeletal traits), whereas in RI they included genes such as , , , and , which may contribute to muscle, bone, and physiological regulation. Functional enrichment analysis revealed numerous genes and Quantitative Trait Loci (QTLs) associated with metabolic, developmental, and immune-related pathways. This study provides the first comprehensive genome-wide CNV profile of Vietnamese indigenous chickens and offers a valuable genomic resource for investigating the genetic basis of breed-specific and adaptive phenotypes. - Source: PubMed
Publication date: 2026/04/01
Nguyen Thuy Thi-DieuTzvetkova AnaBui Mai Thi-DieuDo Vo-Anh-KhoaDinh Thuy Thi-NgocNguyen Phuong ThanhKuss Andreas WalterPenasa MauroCendron Filippo - Although anti-Zic4 antibodies are associated with paraneoplastic cerebellar degeneration, predominantly in small-cell lung carcinoma, their role in postinfectious autoimmunity remains poorly understood. - Source: PubMed
Suzuki-Yamamoto RisaNakajima AsukaFuruya TsuyoshiKoinuma TakahiroFuse AtsuhitoEguchi HirotoShimo Yasushi