DCXR Antibody (monoclonal) (M03)
- Known as:
- DCXR Antibody (mab) (M03)
- Catalog number:
- AT1728a
- Category:
- -
- Supplier:
- Abgen
- Gene target:
- DCXR Antibody (monoclonal) (M03)
Related genes to: DCXR Antibody (monoclonal) (M03)
- Gene:
- CENPJ NIH gene
- Name:
- centromere protein J
- Previous symbol:
- MCPH6
- Synonyms:
- CPAP, BM032, LAP, LIP1, Sas-4, SASS4, SCKL4
- Chromosome:
- 13q12.12-q12.13
- Locus Type:
- gene with protein product
- Date approved:
- 2002-02-15
- Date modifiied:
- 2018-02-13
- Gene:
- CENPN NIH gene
- Name:
- centromere protein N
- Previous symbol:
- C16orf60
- Synonyms:
- FLJ13607, FLJ22660, BM039
- Chromosome:
- 16q23.2
- Locus Type:
- gene with protein product
- Date approved:
- 2006-02-20
- Date modifiied:
- 2015-08-24
- Gene:
- DCXR NIH gene
- Name:
- dicarbonyl and L-xylulose reductase
- Previous symbol:
- -
- Synonyms:
- KIDCR, DCR, SDR20C1
- Chromosome:
- 17q25.3
- Locus Type:
- gene with protein product
- Date approved:
- 2002-07-25
- Date modifiied:
- 2018-07-10
- Gene:
- DONSON NIH gene
- Name:
- downstream neighbor of SON
- Previous symbol:
- C21orf60
- Synonyms:
- B17, C2TA, DKFZP434M035
- Chromosome:
- 21q22.11
- Locus Type:
- gene with protein product
- Date approved:
- 2000-02-18
- Date modifiied:
- 2017-03-30
- Gene:
- EAPP NIH gene
- Name:
- E2F associated phosphoprotein
- Previous symbol:
- C14orf11
- Synonyms:
- BM036, FLJ20578
- Chromosome:
- 14q13.1
- Locus Type:
- gene with protein product
- Date approved:
- 2002-11-18
- Date modifiied:
- 2016-02-26
Related products to: DCXR Antibody (monoclonal) (M03)
Related articles to: DCXR Antibody (monoclonal) (M03)
- Clinically diagnosed pulmonary tuberculosis (cPTB, PTB diagnosis despite negative bacteriological results) accounts for 36% of global PTB notifications, but factors influencing the diagnosis and its relationship with mortality are not well-characterised. We aimed to identify factors associated with cPTB and assess its association with mortality. - Source: PubMed
Publication date: 2026/09/30
Kagujje MaryKerkhoff Andrew DMaimbolwa MinyoiSanjase NsalaShuma BrianMuzazu SekeHermans Sabine MGrobusch Martin PMuyoyeta Monde - Digital chest X-ray (dCXR) enables early TB detection where symptoms screening is inadequate. We evaluated the impact and cost of three dCXR delivery models: long-term community-based mobile vans (LT-vans), long-term facility-based containers (LT-containers), and short-term community-based mobile vans (ST-vans), implemented by a non-governmental organisation (NGO) across two South African provinces. - Source: PubMed
Publication date: 2026/09/15
Coetzee LEvans DFononda AHausler HBooyens LSteingo JHirasen KJamieson LKubjane MMeyer-Rath G - Mitochondrial dysfunction is linked to sleep disorders in previous report, but the potential roles of specific genes remain unclear. This study aimed to dissect different subtype-specific genetic associations and their underlying mechanisms. A multi-omics Summary-data-based Mendelian Randomization (SMR) approach was performed to identify potential causal links between mitochondrial function-related genes and sleep disorders. We integrated GWAS data from FinnGen database (the discovery set), independent GWAS datasets (covering different sleep-disorder subtypes and used for validation), and cis-QTLs (including mQTLs, eQTLs, and pQTLs) to perform systematic exploration. Specially, we performed targeted validation of tissue-specific effects, leveraging gene expression data from disease-relevant brain regions within the GTEx database. Our SMR analysis identified mitochondrial function-related genes potentially modulating sleep disorders across biological layers, initially identifying 102 genes at the methylation level, 48 at the gene expression level, and 6 at the protein abundance level. Integrative analysis subsequently prioritized DCXR and ACADVL and revealed their distinct, subtype-specific associations. DCXR exhibited a protective role in sleep apnea while ACADVL showed a paradoxical risk conferring role in daytime sleepiness. In addition, the analysis identified an epigenetic regulatory mechanism for DCXR in which its expression and protein levels are modulated by DNA methylation. Finally, validation in brain-hypothalamus tissue confirmed DCXR as a significant potential protective factor (OR = 0.929, 95% CI: 0.887-0.973, P_HEIDI = 0.999, FDR = 0.2449). Our findings implicate key mitochondrial genes, particularly DCXR and ACADVL, in the pathophysiology of specific sleep disorder subtypes, highlighting potential avenues for precision medicine. Clinical trial number: Not applicable. - Source: PubMed
Publication date: 2026/09/12
Xu JunjunZhang ZiyanYu LiuyangFeng Yi - Tuberculosis (TB) remains the leading cause of death among persons with advanced HIV disease (AHD) in high HIV-burden settings. Digital chest X-ray (dCXR) with computer-aided detection (CAD) is a promising tool to overcome human resource constraints and improve TB case detection. This study evaluates the real-world implementation and performance of dCXR/CAD for TB screening within a specialized AHD clinic in Maputo, Mozambique. We conducted a retrospective cohort analysis of 487 new AHD patients at Centro de Referência do Alto Maé (CRAM) from October 2023 to September 2024. Of these, 238 underwent dCXR with CAD interpretation. All patients underwent systematic TB screening according to Ministry of Health (MoH) guidelines. Using the recorded diagnosis of TB (bacteriologically confirmed or clinically diagnosed) as the reference standard, we calculated the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the nationally adopted CAD threshold (≥0.5). Among 238 AHD patients screened with CAD, 116 (49%) were diagnosed with TB. At the ≥0.5 threshold, sensitivity was 50% (58/116; 95% CI: 41-59), specificity 92% (112/122; 95% CI: 85-96), PPV 85% (58/68; 95% CI: 75-92), and NPV 65.9% (112/170; 95% CI: 58-73). TB diagnosis rates increased sharply with CAD score: 30% (43/143) in normal, 52% (15/27) in abnormal non-suggestive, and 85% (58/68) in suggestive cases. Bacteriological confirmation was low across all groups (19-26%), reflecting reliance on clinical diagnosis. Integrating dCXR/CAD into AHD care is feasible and identifies a high TB burden. However, at the adopted threshold of ≥0.5, CAD demonstrated high specificity but low sensitivity (50%) in this population, missing half of all TB cases. These findings suggest that CAD functions better as a confirmatory decision-support tool than a standalone screening test in AHD. Threshold optimization for this specific population warrants prospective evaluation. Implementation challenges including fragmented systems and lack of dedicated human resources must be addressed to realize CAD's full potential in TB programs. - Source: PubMed
Publication date: 2026/07/30
Ruano Camps MariaJose BenditaZindoga PereiraCouto AlenyCumbe CeliaMuvale GilBene RosaCossa Admilson FShapiro Adrienne ELane JeffMudender FlorindoNacarapa Edy - Gestational diabetes mellitus (GDM) poses significant health risks, yet the causal genetic and epigenetic mechanisms linking glycolipid metabolism dysregulation to GDM remain elusive. This study aimed to identify key causal genes and regulatory pathways by integrating multi-omics data with large-scale genetic association studies. - Source: PubMed
Publication date: 2026/05/20
Lin XiaoxiaoZheng JingjingQin NingningLi Yimei