FLNA Antibody (Y1046)
- Known as:
- FLNA Antibody (Y1046)
- Catalog number:
- AP7770a
- Category:
- -
- Supplier:
- Abgen
- Gene target:
- FLNA Antibody (Y1046)
Related genes to: FLNA Antibody (Y1046)
- Gene:
- FLNA NIH gene
- Name:
- filamin A
- Previous symbol:
- FLN1, FLN, OPD2, OPD1
- Synonyms:
- ABP-280
- Chromosome:
- Xq28
- Locus Type:
- gene with protein product
- Date approved:
- 1993-03-18
- Date modifiied:
- 2019-04-23
Related products to: FLNA Antibody (Y1046)
Related articles to: FLNA Antibody (Y1046)
- ObjectiveDisulfidptosis, a newly discovered mechanism of cell death, may play a significant role in cancer initiation, progression, and prognosis. However, studies on the prognostic role of Disulfidptosis-Related Genes (DRGs) across cancers remain limited. This study aims to systematically explore the prognostic value of DRGs in various cancer types by constructing a prognosis model based on DRGs and analyzing their associations with tumor biological characteristics.MethodsThis was a pan-cancer bioinformatics study combined with in vitro qRT-PCR validation. Public transcriptomic and clinical data from cancer patients were obtained from The Cancer Genome Atlas (TCGA). Samples were randomly divided into training and validation cohorts at a 1:1 ratio. In the training cohort, least absolute shrinkage and selection operator (LASSO) regression was used to identify prognosis-related DRGs, followed by multivariate Cox regression to construct a DRG-based risk score. The prognostic value of the risk score was evaluated using Cox regression, Kaplan-Meier survival analysis, and nomogram construction. Gene set activity analysis was performed to assess the associations between the DRG score and tumor-related biological processes, including angiogenesis, epithelial-mesenchymal transition (EMT), and cell cycle activity. To further validate the expression patterns of key DRGs in osteosarcoma, osteosarcoma-related transcriptomic data from TARGET and normal tissue data from GTEx were analyzed. The 16 selected DRGs were intersected with osteosarcoma-related differentially expressed genes, and 10 overlapping genes were further validated by qRT-PCR in osteosarcoma cell lines and normal osteoblasts.ResultsKey DRGs identified via LASSO regression showed significant prognostic value in pan-cancer analysis. The resulting risk model effectively stratified patients by survival outcomes and performed well in both training and validation cohorts, indicating strong clinical potential. SsGSEA revealed associations between DRG risk scores and malignant tumor features such as angiogenesis, EMT, and cell cycle dysregulation. Differential expression and GO enrichment analyses indicated that related genes were involved in metabolism, apoptosis, and immune processes. qRT-PCR validation in normal osteoblasts (hFOB) and seven osteosarcoma cell lines showed that NDUFA11 and NDUFS1 were generally downregulated, whereas ACTB, WASF2, FLNA, PRC1, ACTN4, PGD, RAC1, and FLNB were generally upregulated in most osteosarcoma cell lines compared with hFOB cells. These expression patterns were broadly consistent with the bioinformatics results and support the potential relevance of these genes in osteosarcoma progression.ConclusionBy constructing a prognostic model based on DRGs, this study reveals the significant prognostic value of DRGs across pan-cancers and further validates their association with tumor malignant characteristics. The results suggest that DRG score can serve as an effective prognostic indicator for cancer patient survival and have specific implications in osteosarcoma. In the future, DRG-based scoring systems may serve as novel biomarkers and therapeutic targets. - Source: PubMed
Publication date: 2026/06/29
Wang JinqiuHuang HuiLiu Dehuai - Myxomatous mitral valve disease (MMVD) is a progressive cardiac disease characterized by extracellular matrix remodeling, leaflet thickening, and proteoglycan accumulation. Despite its significant contribution to cardiovascular morbidity and mortality, the underlying pathophysiological mechanisms involved in its development and progression remain unclear. Recent investigations have revealed a genetic component to the disease, such as mutations in the FLNA gene, and suggested potential involvement of immune cells in the pathogenesis of MMVD. In this study, we investigated the role of macrophages in MMVD using a large collection of human non-syndromic MMVD samples and a unique animal model, the Filamin-A knock-in (KI) rat. - Source: PubMed
Publication date: 2026/06/23
Le Vely BenjaminDelwarde ConstanceToquet ClaireAumond PascalBlank-Stein NelliCharon EmilieRémy SéverineAnegon IgnacioMyasoedova Veronika AValerio VincenzaPoggio PaoloLe Scouarnec SolenaSchott Jean-JacquesLe Tourneau ThierryMerot JeanMass ElviraCapoulade Romain - Dysregulation of Speckle-type POZ protein (SPOP) and cargo receptor p62/SQSTM1 impairs homologous recombination (HR)-mediated DNA repair by destabilizing RAD51 and FLNA, yet their mechanistic interplay in genomic stability and oncogenesis remains unclear. In this study, we found that the interaction between SPOP and p62/SQSTM1 is obviously enhanced in nucleus in response to DNA damage. Moreover, the nuclear ubiquitination of p62/SQSTM1 at lysine 7 by SPOP led to its degradation, resulting in upregulation of RAD51 and FLNA, RAD51 foci formation, and HR efficiency. In addition, patients-derived p62/SQSTM1 mutations in SPOP-binding consensus (SBC) motif (S276Y/S277G/S277I) increased radiotherapy sensitivity in vitro and in vivo, which attributes to HR deficiency caused by increased degradation of RAD51 and FLNA proteins, and decreased RAD51 and γ-H2AX foci formation. Our finding provides insight into the regulation of HR by SPOP and p62/SQSTM1, and disrupting the interaction between SPOP, p62/SQSTM1 and nuclear ubiquitination may be a potential approach for overcoming radiotherapy resistance in cancer. - Source: PubMed
Publication date: 2026/06/20
Yang XiaojuanZhou YingHuang QingWang LingliZhang SuYang XuyangQiu LeiMeng YangWu HongZhang BoXie KunlinHan JunhongZhu Qing - Disulfidptosis and cuproptosis are recently identified forms of regulated cell death whose component genes may harbor prognostic information in oral squamous cell carcinoma (OSCC). However, no validated multi-gene prognostic signature derived from these pathways has been established. - Source: PubMed
Publication date: 2026/06/19
Yao YaoLi XiaoshanPang ZiyanKang WenmingGong LiqiangZhou QiMao Chen - Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disorder characterized by unpredictable flares and variable clinical quiescence. Despite validated clinical indices like the British Isles Lupus Assessment Group (BILAG) score, reliable molecular biomarkers for monitoring disease activity remain limited, particularly in underrepresented South Asian populations. Weaimed to identify arobust molecular framework to distinguish SLE flares from remission in an Indian cohort. - Source: PubMed
Publication date: 2026/06/03
Karmakar AbhibrotoMishra SantanuKumar UmaKamath RachanaRavindran VinodSuryakanth Varashree BolarPrabhu SmithaNagaraju Shankar PrasadPrabhu Mukhyaprana MKarmakar Subhradip