SERPINF1 Antibody (Center)
- Known as:
- SERPINF1 Antibody (Center)
- Catalog number:
- AP7315c
- Category:
- -
- Supplier:
- Abgen
- Gene target:
- SERPINF1 Antibody (Center)
Related genes to: SERPINF1 Antibody (Center)
- Gene:
- SERPINF1 NIH gene
- Name:
- serpin family F member 1
- Previous symbol:
- PEDF
- Synonyms:
- EPC-1, PIG35
- Chromosome:
- 17p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1993-05-18
- Date modifiied:
- 2018-03-02
Related products to: SERPINF1 Antibody (Center)
Related articles to: SERPINF1 Antibody (Center)
- To develop and assess a hypoxia-associated gene signature for diabetic kidney disease (DKD), and to examine its relationship with immune remodeling and molecular heterogeneity. - Source: PubMed
Publication date: 2026/09/14
Ji YueZhang JiakunGuo XiXiao YunmingWang TieshanZhang YifeiGuo ZhixunWu YuqiYou LiangzhenLiu Wei Jing - Fibroblasts are mesenchymal cells in the healthy vascular adventitia. In atherosclerosis, single-cell sequencing datasets suggest fibroblasts are abundant in plaques. However, their identity, origin, and fate during plaque progression remain unclear, which we aim to unravel here. - Source: PubMed
Publication date: 2026/09/09
Li GuanliangAsselberghs Sebastiaan E JYu BaixueFeng CongMendez Paul-LennardKasakovski DimitriGoossens PieterAckermans Tia MTillie Renée J H AGijbels Marion JTemmerman LieveXu HeDonners Marjo M P CKheder Dlzar AMaryam SidrahJin HanXue ChenyiHayat SikanderConklin Austin CRomanoski Casey EGiacca MauroMiller Clint LReilly Muredach PChen MingKramann RafaelMees BarendBaker Andrew HSluimer Judith C - Pigment epithelium-derived factor (PEDF) is a potent endogenous immunomodulatory protein with anti-metastatic, anti-angiogenic, and anti-inflammatory properties, and has recently gained attention for its ability to target tumor cells across various cancers. However, the molecular mechanism underlying the effects of PEDF on angiogenesis and metastasis in anaplastic thyroid cancer (ATC), one of the most lethal and aggressive human malignancies, remains poorly understood. In this study, the PEDF coding sequence was cloned into a lentiviral backbone plasmid vector, and its effects on metastasis and epithelial-to-mesenchymal transition (EMT) were assessed in 8305C ATC cells using RT-qPCR, migration, invasion, doubling time, wound healing assays, as well as western blot analysis. Angiogenesis was evaluated using the chicken chorioallantoic membrane (CAM) assay. Overexpression of PEDF in 8305C cells significantly reduced the expression of VEGF and HIF-1α, downregulated angiogenesis-related genes, and was associated with reduced expression of PI3K/AKT-related genes. Additionally, PEDF overexpression markedly decreased MMP-9 and MMP-2 levels, leading to reduced invasion, migration, and EMT-associated phenotype. These findings suggest that PEDF overexpression is associated with reduced angiogenic and metastatic phenotypes in ATC cells and warrants further investigation in additional preclinical models. - Source: PubMed
Publication date: 2026/09/04
Khoshnazar AminehKoochaki AmenehAnajafi SaraKhazaei-Poul YaldaGhanbarian HosseinMohammadi-Yeganeh SamiraParyan MahdiHaghpanah Vahid - To elucidate the genetic etiology of osteogenesis imperfecta (OI) in affected families and to characterize reproductive decision-making, reproductive interventions, and pregnancy outcomes of these families. - Source: PubMed
Publication date: 2026/09/05
Yuan ShiminHu XiaoYi DuoZhao XiaomengWan ZhenxingHe Wen-BinHu LiangLu GuangxiuLin GeTan Yue-QiuDu Juan - Pigment epithelium-derived factor (PEDF) promotes photoreceptor survival through its receptor PEDF-R, a phospholipase involved in retinal lipid metabolism. To define the in vivo function of the PEDF/PEDF-R axis, we generated mice lacking (PEDF) and (PEDF-R). Combined loss of and resulted in severe retinal degeneration characterized by outer nuclear layer (ONL) thinning, outer segment (OS) shortening, reduced rhodopsin and cone opsin expression, increased TUNEL-positive nuclei, and enhanced retinal autofluorescence associated with altered lipid distribution. Lipid-associated markers, including TIP47, PLIN5, and BODIPY, exhibited abnormal distribution patterns in mutant retinas, indicating disrupted lipid storage and trafficking. Loss of PEDF/PEDF-R signaling also impaired photoreceptor-rod bipolar cell connectivity, as demonstrated by reduced PKCα/synaptophysin colocalization, and resulted in diminished electroretinographic responses. Lipid Imaging mass spectrometry revealed decreases in some lipid abundances in photoreceptor outer segment and inner segment/outer nucleus layer, while lipids containing arachidonic acid and docosahexaenoic acid-containing lipids showed increased abundance. Together these findings identify the PEDF/PEDF-R signaling axis as a key regulator of retinal phospholipid homeostasis that couples lipid metabolism to photoreceptor survival and visual function. - Source: PubMed
Publication date: 2026/08/09
Bernardo-Colón AlexandraCrawford Susan EAgbaga Martin PaulWang ZhenSchey KevinBecerra S Patricia