LAX1 Antibody (C-term)
- Known as:
- LAX1 Antibody (C-terminus)
- Catalog number:
- AP18643b-ev20
- Category:
- -
- Supplier:
- Abgen
- Gene target:
- LAX1 Antibody (C-term)
Related genes to: LAX1 Antibody (C-term)
- Gene:
- LAX1 NIH gene
- Name:
- lymphocyte transmembrane adaptor 1
- Previous symbol:
- -
- Synonyms:
- LAX, FLJ20340
- Chromosome:
- 1q32.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-04-25
- Date modifiied:
- 2014-11-19
Related products to: LAX1 Antibody (C-term)
Related articles to: LAX1 Antibody (C-term)
- Pancreatic cancer remains highly lethal, largely due to late diagnosis and limited efficacy of treatments. Improving first-line treatment selection and patient monitoring requires novel, non-invasive biomarkers beyond carbohydrate antigen 19-9 (CA19-9) and imaging. This study investigates epigenetic biomarkers from liquid biopsy with prognostic and predictive potential in metastatic pancreatic ductal adenocarcinoma (PDAC; mPDAC). Genome-wide methylation profiling of cell-free DNA (cfDNA) from healthy individuals and stage IV mPDAC patients identified 13 gene-associated CpG sites with significantly altered methylation patterns. ddPCR validation confirmed consistent methylation differences in lymphocyte transmembrane adaptor 1 (), nuclear receptor subfamily 3 group C member 1 (), and between healthy and patient groups. Elevated and methylation and reduced methylation at diagnosis were associated with poor prognosis and correlated with high-risk circulating biomarker profiles, including CA19-9 levels, MAF (mutant allele fraction), cfDNA concentration, and cfDNA fragmentation. Notably, baseline methylation levels predicted response to first-line FOLFIRINOX-based treatment with an acceptable 75% sensitivity and a high specificity of 92.86%. These findings highlight the clinical significance of cfDNA methylation as a minimally invasive biomarker source, emphasizing , , and as prognostic biomarkers in mPDAC. Specifically, baseline methylation emerges as a promising predictor of treatment response, supporting personalized therapeutic strategies in mPDAC. - Source: PubMed
Publication date: 2026/03/22
Cano-Ramírez PabloToledano-Fonseca MartaCano-Osuna María TeresaHerrera-Casanova NereaCarrillo-Pecero EmilioRodríguez-Ariza AntonioAranda EnriqueGarcía-Ortiz María Victoria - Genetic transformation of elite crop varieties remains limited by genotype-specific recalcitrance and dependence on tissue culture. This review provides a comprehensive analysis of current transformation platforms and emerging strategies to overcome these bottlenecks. We examine traditional -mediated and biolistic methods, then critically assess tissue culture-free approaches including floral-based delivery, cut-dip-budding, injection, and viral vector-mediated transformation systems. A major focus is the deployment of developmental regulators-, chimeras, transcription factors, , , and -that enhance regeneration efficiency across genotypes. We detail their molecular mechanisms, from chromatin remodeling and auxin gradient establishment to wound-responsive cell reprogramming. Importantly, we address the pleiotropic developmental costs of DR misexpression and review precision control technologies, including promoter optimization and auto-excision systems, that enable transient DRs activity during regeneration while ensuring normal plant development. We propose a roadmap for integrating these advances to achieve genotype-flexible, high-throughput transformation applicable to molecular design breeding.(1). - Source: PubMed
Publication date: 2026/03/11
Guo YajieLi MengyaoLiu MengtianLiu Huiyun - Efficient in vitro regeneration remains a major constraint in the genetic transformation, genome editing, and molecular breeding of wheat ( L.), largely due to strong genotype-dependent recalcitrance and limited activation of developmental programs required for somatic embryogenesis. Plant regeneration relies on extensive transcriptional reprogramming and epigenetic remodeling orchestrated by morphogenic regulators that modulate meristem identity, as well as cellular pluri- and totipotency. In this review, we synthesize current molecular knowledge on key transcription factors (, , , , , , ) and signaling peptides ( module, phytosulfokine/) that regulate embryogenic competence in monocot cereals, with emphasis on their orthologs and functional relevance in wheat. We highlight how controlled expression of these morphogenic genes, promoter engineering, and transient or excisable induction systems can significantly enhance regeneration capacity, reduce chimerism in CRISPR-Cas-edited plants, and facilitate genotype-independent transformation. We also discuss epigenetic and metabolic constraints underlying wheat recalcitrance and their potential modulation to improve culture responsiveness. By integrating evidence from wheat, rice, maize, and barley, we outline conserved gene-regulatory networks that reinitiate totipotency and propose strategies to accelerate doubled haploid production and speed-breeding pipelines. Collectively, morphogenic factors emerge as central molecular tools for overcoming regeneration bottlenecks and enabling next-generation wheat improvement. The objective of this review is to synthesize and critically evaluate current molecular knowledge on morphogenic regulators controlling in vitro regeneration in wheat ( L.), with particular emphasis on their roles in genetic transformation and genome editing. - Source: PubMed
Publication date: 2026/01/27
Kowalik SylwiaSamoń MonikaPrzyborowski Mateusz - The relationship between Alzheimer's disease (AD) and chronic periodontitis (PD) rarely share the medical spotlight, yet epidemiological mirroring hints at a common inflammatory root. - Source: PubMed
Publication date: 2025/12/12
Guo HanGuo TianyuanWang XueBao YangZhang ZhiyongXue FangCheng Dongmei - OsAAI1 belongs to the HPS_like subfamily of the AAI_LTSS superfamily, yet the molecular mechanism by which it regulates root development under osmotic stress remains unclear. In this study, we found that overexpressing OsAAI1 significantly promoted rice root system growth. Specifically, the primary root length, lateral root number, lateral root density and adventitious root count in the overexpression line (OE19) markedly exceeded those in the wild type (ZH11) and the osaai1 mutant. Consistent with this phenotypic enhancement, the root IAA content in OE19 was substantially higher than in ZH11 and osaai1. We further demonstrated that exogenous IAA application compensated for the root growth defects in the osaai1 mutant. Under PEG-induced osmotic stress, OE19 exhibited the most extensive and densely distributed root system, and exogenous IAA also rescued the inhibited growth of the osaai1 mutant. Mechanistically, we identified an interaction between OsAAI1 and the MADS-box transcription factor OsMADS25. This interaction enhanced the transcriptional expression of two key osmotic stress tolerance genes, LAX1 and OsBAG4. Furthermore, it upregulated the auxin biosynthesis gene OsYUC4 while suppressing the auxin inhibitory factor OsIAA14. This coordinated gene regulation promotes the auxin signalling pathway, thereby stimulating root growth and enhancing osmotic stress tolerance. Collectively, our findings indicate that OsAAI1 and OsMADS25 fulfil critical functions in rice osmotic acclimation by orchestrating downstream gene expression and modulating the auxin pathway. - Source: PubMed
Publication date: 2025/11/27
Xu NingLuo RuiLong QingMan JianminLiu JinliChen ShashaYin JiaxiLiao HaiminJiang Meng