IL20RA Antibody (Center)
- Known as:
- IL20RA Antibody (Center)
- Catalog number:
- AP17436c-ev20
- Category:
- -
- Supplier:
- Abgen
- Gene target:
- IL20RA Antibody (Center)
Related genes to: IL20RA Antibody (Center)
- Gene:
- IL20RA NIH gene
- Name:
- interleukin 20 receptor subunit alpha
- Previous symbol:
- -
- Synonyms:
- ZCYTOR7, IL-20R1
- Chromosome:
- 6q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 2000-05-23
- Date modifiied:
- 2015-12-11
Related products to: IL20RA Antibody (Center)
Related articles to: IL20RA Antibody (Center)
- Microplastic (MP) pollution has become a global aquatic environmental issue, yet its long-term toxic effects on aquatic organisms remain poorly understood. In this study, grass carps (Ctenopharyngodon idella) were subjected to thirty-week dietary exposure to polystyrene microplastics (PS-MPs) to systematically evaluate the effects on histology, immune signaling, and intestinal microbiota. Histopathological examination revealed that PS-MPs exposure induced focal necrosis, increased melanomacrophage centers, and sinusoidal congestion in the spleen, while the intestine exhibited villus fusion, disordered arrangement, epithelial edema, and lymphocyte infiltration. Transcriptomic analysis further identified 2975 differentially expressed genes (DEGs) in the spleen. Functional enrichment analysis revealed that these DEGs were significantly associated with cytokine-cytokine receptor interaction, Toll-like receptor, RIG-I-like receptor, and NOD-like receptor signaling pathways. Notably, the MAPK-associated gene mapkapk3 was significantly upregulated, whereas the immune-regulatory receptor gene IL20RA was downregulated, suggesting disruption of immune homeostasis and remodeling of innate immune signaling. Gut microbiota analysis revealed marked dysbiosis characterized by increased relative abundances of Fusobacteriota (57%) and Proteobacteria (35%), accompanied by pronounced reductions in Bacteroidota and Firmicutes. All alpha diversity indices (Chao1, Ace, Shannon, Simpson) were significantly decreased, and beta diversity analyses (PCA, PCoA, NMDS) demonstrated clear separation between groups. The opportunistic pathogen Aeromonas veronii was significantly enriched and identified as a key biomarker in the PS-MPs group. Collectively, long-term PS-MPs exposure induced structural tissue damage, altered immune-related transcriptional profiles involving mapkapk3 and IL20RA, and promoted gut microbial dysbiosis with enrichment of opportunistic pathogens, thereby potentially increasing host susceptibility to environmental stressors. These findings provide mechanistic insight into the ecological health risks posed by chronic MP exposure in freshwater fish. - Source: PubMed
Publication date: 2026/07/13
Chen YixuanZheng MingpengXie MinminZhang PinpinZhang YingLiu YiZhou Chuang - Keloid is a pathological skin fibrosis disease characterized by abnormal proliferation of dermal fibroblasts and excessive deposition of extracellular matrix (ECM). Its high recurrence rate necessitates an in-depth investigation of molecular mechanisms to develop effective treatment strategies. - Source: PubMed
Publication date: 2026/06/24
Lu HaitaoZhao YunhuaLi BaoqiangYao YinhuiLiu LijunLiu LiyuanZhang JialiHe LeiDuan Xinsuo - The dynamic crosstalk between the tumor microenvironment (TME) and triple negative breast cancer (TNBC) cells plays a critical role in tumor progression and treatment resistance. Recent studies have highlighted the involvement of IL-20 receptor subunit alpha (IL-20RA) signaling in BC, where its overexpression modulates oncogenic pathways contributing to invasion and metastasis. Epigenetic dysregulation by Bromodomain and Extra-Terminal domain (BET) proteins critically influences key oncogenic pathways and cytokine expression in TNBC. Given that the BET-inhibitor JQ1 blocks TNBC cell growth, in this study we investigated its potential regulatory effects on the IL-20RA pathway. IL-20RA was found expressed across multiple BC cell lines compared to non-tumorigenic cells, with the highest levels detected in MDA-MB-231 and MDA-MB-468 cells. In both cell lines, JQ1 treatment significantly downregulated IL-20RA expression at gene and protein levels, accompanied by a reduction in the oncogenic JAK/STAT signaling pathway, and programmed death-ligand 1 (PD-L1) expression. Parallel in vivo experiments using TNBC xenograft models confirmed these findings, showing reduced IL-20RA and PD-L1 expression alongside decreased phosphorylation of JAK and STAT3. Overall, this study uncovers a novel interplay between BET inhibition and the IL-20RA/STAT3 axis, suggesting JQ1 as a valid therapeutic option for TNBC characterized by high IL-20RA expression. - Source: PubMed
Publication date: 2026/06/09
Maggisano ValentinaPanza SalvatoreVerrienti AntonellaLombardo Giovanni EnricoCatalano StefaniaBulotta Stefania - Degenerative lumbar spine disorders (DLSD), including intervertebral disc disorders (IDD), degenerative spondylolisthesis, and lumbar spinal stenosis (LSS), are major contributors to low back pain and disability. Associations among gut microbiota (GM), inflammatory proteins, and DLSD have been demonstrated in prior studies. Yet, two key questions persist: whether specific circulating inflammatory proteins (IPs) mediate this association, and whether such mediation is shared across different diseases. - Source: PubMed
Publication date: 2026/06/03
Lou YongfuMa DaoyiGan QingquanXu XianyueXiao YimingWang JunzhuoLi ZhibingZhang TaoQi LeiFeng Shiqing - Circular RNAs (circRNAs) are increasingly recognized as key post-transcriptional regulators. However, their functions within the avian hypothalamic-pituitary-ovarian (HPO) axis remain poorly understood. To investigate potential associations of circRNAs with breed differentiation and reproductive traits, we constructed cross-tissue circRNA profiles through whole-transcriptome sequencing of the HPO axis in Zi and Xianghai flying geese. A total of 90, 80, and 90 DE-circRNAs were identified in the hypothalamus, ovary, and pituitary, respectively, corresponding to 248 non-redundant DE-circRNA IDs across the three tissues. Functional enrichment analysis revealed that their host genes were significantly enriched in reproduction-related signaling pathways, including cAMP, PI3K-Akt, FoxO, JAK-STAT, GnRH, and VEGF signaling pathways. GO terms related to reproduction, reproductive process, and growth were significantly enriched, with protein interaction analysis identifying CYP19A1, FSHR, BMP15, and ESR1 as central network hubs. Furthermore, through systematic integration of cross-tissue circRNA, miRNA, and mRNA expression profiles and a series of analytical steps including correlation-based filtering and hypergeometric testing, we thereby constructed a cross-tissue ceRNA network. Several functional modules were identified, including novel_circ_000988-miR-1451-y/miR-216-x/miR-735-x-IL20RA, novel_circ_019479-miR-1338-y/miR-1388-y-GLRA2, and novel_circ_010669-miR-143-z-Med27. Our results indicate that circRNAs may be associated with a cross-tissue neuroendocrine-ovarian regulatory network through putative ceRNA-associated interactions, providing candidate molecular insights into reproductive trait variation in geese. - Source: PubMed
Xie LinhongZhao ZhonglongZhang YonghongZhan KunYuan ManSun HaoZhang XiaojunYang SibaoYang Yuwei