Mouse Prkcd Antibody (N-term)
- Known as:
- Mouse Prkcd Antibody (N-terminus)
- Catalog number:
- AP14629a
- Category:
- -
- Supplier:
- Abgen
- Gene target:
- Mouse Prkcd Antibody (N-term)
Related genes to: Mouse Prkcd Antibody (N-term)
- Gene:
- PRKCD NIH gene
- Name:
- protein kinase C delta
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 3p21.1
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-06
- Date modifiied:
- 2019-04-23
Related products to: Mouse Prkcd Antibody (N-term)
Related articles to: Mouse Prkcd Antibody (N-term)
- India possesses a rich diversity of indigenous cattle that are well adapted to varied agro-climatic regions. These populations exhibit remarkable variation in stature (height at withers), ranging from short-statured types such as Vechur, Punganur, Malnad Gidda, and Khariar to tall and heavy breeds like Kankrej, Ongole and other milch breeds (Sahiwal, Gir, etc.). The short-statured breeds offer potential advantages in feed efficiency, disease resilience, and cultural value besides being economical to maintain. However, their genetic basis for stature remains underexplored. This study leverages whole-genome resequencing (WGS) data on short-statured (n = 19) and tall (Kankrej as representative; n = 19) Indian cattle to delineate the copy number variation (CNV) landscape and selection signatures underpinning stature divergence. Post-quality control, CNVs were detected from duplicate-marked bam files using CNVnator with read-depth methodology, filtered (q0 < 0.5, p < 0.01, size 1 kb-5 Mb), and concatenated into CNV regions (CNVRs). Selection signatures were identified using cross population extended haplotype homozygosity (XP-EHH) methodology for inter-population comparison of short-statured cattle with tall cohort. Genes harboured under CNVRs and sweep windows were annotated using GALLO, with functional mining from literature databases. In short-statured cattle, 41,913 CNVs were concatenated into 10,075 CNVRs, with 8.01% genomic coverage. A total of 25 genes were found to be common across two analyses i.e., unique (non-overlapping) CN regions in 70% short-statured individuals and scan of selection signature. Key genes across the analyses included IGF1R (cell proliferation), FGFR3 (skeletal growth), SOX6 (body size), EXT2/LGR4 (bone density), PRKCD (developmental regulation), ADAMTSL2 (extracellular matrix integrity), SLC25A6 (glucose metabolism), and SDHA (energy supply). Unique non-overlapping copy number regions (e.g., 78 regions found in 100% of dwarf individuals) harbored several genes, including ARL13B (osteogenesis), AXIN2 (bone remodeling), CCND2 (myogenesis), and TNNT1 (muscle contraction). This comprehensive CNV map and scan for signatures of selection unveil stature-associated genomic variants, informing conservation strategies for threatened short-statured breeds by enhancing their socio-economic value through targeted breeding. The findings underscore CNVs as pivotal drivers of phenotypic diversity in cattle populations, with implications for livestock genomics and sustainable agriculture. - Source: PubMed
Publication date: 2026/06/08
Ahmad Sheikh FirdousAarif OvaisHassan Mir MehrozChand RoshniGangwar MunishT Sarath KumarKumar Amit - Autophagy plays a non-negligible role in the progression and immune regulation of hepatocellular carcinoma (HCC). An integrated analysis of the autophagy-related genes (ARGs) is of significance to deepen our mechanistic understanding about HCC pathology. In our present work, based on the expression patterns of 221 ARGs, we first identified 2 autophagy-related subtypes for TCGA-HCC patients using consensus clustering method. The two subtypes showed considerable distinctions in terms of molecular characteristics, immune landscapes and clinical outcomes. To augment the clinical utility of the subtyping system, a four-gene prognostic model including ATIC, RHEB, TMEM74 and PRKCD was developed and verified through LASSO and multivariate Cox regression analyses. ROC(AUC) analysis confirmed the predictive efficacy of the model across the training and validation cohorts. Notably, HCC patients in the high-risk group exhibited elevated tumor mutation burdens and higher expression of multiple immune checkpoint genes, suggesting distinct immune-related features between risk groups. Furthermore, single-cell RNA sequencing analysis revealed that the model's marker gene-ATIC was predominantly expressed in tumor cells and proliferative T cells, with its expression showing strong and positive associations with autophagy activity. Finally, in vitro experiments were conducted to explore the potential role of ATIC in HCC. The results indicated that ATIC knockdown was associated with reduced proliferative and migratory capacities of HCC cells, along with alterations in autophagy-related phenotypes, including decreased autophagic flux. Taken together, our study provides a preliminary autophagy-related prognostic signature and identifies ATIC as a potential regulator of HCC progression. - Source: PubMed
Publication date: 2026/06/08
Xie LonghuiWang TiantianPan ChangbinLan JianweiYang YangLv LijuanZhou CilaQin ShuangNing Yinkuan - Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by immune cell dysfunction. The endomembrane system, consisting of the endoplasmic reticulum (ER) and Golgi apparatus (GA), plays a central role in protein synthesis and trafficking. However, the regulatory architecture of the ER-Golgi axis in RA immune cells remains incompletely understood. - Source: PubMed
Publication date: 2026/05/15
Shi YangnaZhang WeiLi ChenxiLiu FannaYin LianghongLiu DongzhouHong XiaopingZeng ZhipengLi HaitaoDai YongTang DongeGong Wenyu - Neuroblastoma (NB) is one of the most common malignant tumors in children. Despite intensive multimodal treatments, patients with high-risk NB still have a poor prognosis; therefore, early identification of high-risk patients based on reliable NB biomarkers is essential. Endoplasmic reticulum (ER) stress has been demonstrated to play a vital role in cancer biology; however, it is unclear whether ER stress-related genes are involved in NB and should be further explored as new potential diagnostic and prognostic targets. - Source: PubMed
Publication date: 2026/03/24
Lu WentingZhou RuixiYue YanYing JunjieXiong TaoTang JunShi JingWang HuaZhang LiRuan Tiechao - Leniolisib, a selective phosphoinositide 3-kinase δ (PI3Kδ) inhibitor, is approved in several countries for the treatment of activated PI3Kδ syndrome (APDS) in patients 12 years of age and older. We report the first successful compassionate use of leniolisib in another inborn error of immunity, protein kinase C δ deficiency. In addition to infectious complications, the 14-year-old patient experienced lymphoproliferation in the form of splenomegaly, lymphadenopathy, and thymic hyperplasia; trilineage cytopenia; multiple forms of autoimmunity; and interstitial lung disease. Decision to initiate treatment with leniolisib was based on multiorgan-disease progression, lack of therapeutic alternatives, molecular evidence, overlap with APDS manifestations, and mammalian target of rapamycin hyperactivity. We observed improvement in lymphoproliferation, cytopenias, hepatic cytolysis, skin manifestations, pulmonary function, favorable changes in immunophenotypes, and no known drug-related adverse events. This experience supports expanding Leniolisib's potential indications to appropriately selected patients and conditions. Broader repurposing strategies for targeted therapies in diseases involving dysregulated PI3K signaling should be systematically evaluated in clinical trials. - Source: PubMed
Publication date: 2026/04/20
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