FBXW11 Antibody (Center)
- Known as:
- FBXW11 Antibody (Center)
- Catalog number:
- AP11217c
- Category:
- -
- Supplier:
- Abgen
- Gene target:
- FBXW11 Antibody (Center)
Related genes to: FBXW11 Antibody (Center)
- Gene:
- FBXW11 NIH gene
- Name:
- F-box and WD repeat domain containing 11
- Previous symbol:
- FBXW1B
- Synonyms:
- KIAA0696, Fbw1b, BTRCP2, BTRC2, Hos, Fbw11
- Chromosome:
- 5q35.1
- Locus Type:
- gene with protein product
- Date approved:
- 2000-09-27
- Date modifiied:
- 2015-09-11
Related products to: FBXW11 Antibody (Center)
Related articles to: FBXW11 Antibody (Center)
- Pancreatic ductal adenocarcinoma (PDAC) is characterized by a pronounced Warburg effect and high lactate levels. While lysine lactylation (Kla) is an emerging post-translational modification, its role in regulating the S100A11/ANXA2 complex-a critical driver of membrane repair and metastasis-remains unexplored. In this study, we identified that S100A11 (K3, K55) and ANXA2 (K49) are significantly lactylated in PDAC tissues. Lactate-induced lactylation of S100A11 at K3 and K55 inhibits FBXW11-mediated ubiquitination and proteasomal degradation, thereby stabilizing the protein. This stabilized S100A11 subsequently shields ANXA2 from TRIM21-mediated degradation. Reciprocally, lactylation of ANXA2 at K49 enhances its capacity to recruit S100A11 to the plasma membrane. Functional assays demonstrated that this lactylation-driven interdependent regulatory axis promotes PDAC cell migration, invasion, and metastasis both in vitro and in vivo. Clinical analysis of TCGA data revealed that low expression of both S100A11 and ANXA2 predicts significantly improved progression-free and overall survival in PDAC patients. In summary, our findings establish a novel link between metabolic reprogramming and the post-translational regulation of the membrane repair machinery. Lactylation of the S100A11/ANXA2 axis is a key driver of PDAC progression and serves as a promising prognostic biomarker and potential therapeutic target. - Source: PubMed
Publication date: 2026/07/10
Zheng BoCai LijunDeng YingYang Lan - Protein lactylation, a novel post-translational modification utilizing lactate as the substrate, has emerged as a key mechanism linking metabolic alterations to cancer progression. This study aims to investigate the role and underlying mechanism of S100A11 lactylation in gastric cancer progression and metastasis. - Source: PubMed
Publication date: 2026/07/09
Zhang QingruiZhou YuhangWang FangningYan JingruiLiu JiayuZhang LinDu Shiyu - Despite the well-established role of interleukin-17 (IL-17)-producing γδ T cells (γδT17 cells) in autoimmune inflammations, key factors to trigger the activation of γδT17 cells remain largely unknown. Here, we show that aryl hydrocarbon receptor (AhR) is markedly reduced upon γδT17 cell activation. AhR deficiency and pharmacological activation promotes and suppresses γδT17 cell activation, respectively. Mechanistically, AhR deficiency strengthens heat shock protein family A member 9 (HSPA9)-mediated competition with F-box and WD-40 domain protein 11(FBXW11) for binding to RBP-j-associated molecule (RAM) domain of Notch intracellular domain (NICD), which impairs FBXW11-dependent NICD ubiquitination to increase NICD occupancy at the enhancer to drive γδT17 cell activation. Consistently, AhR deficiency increases the proportion of γδT17 cells and the disease severity in psoriasis-like dermatitis mice and colitis mice, which is almost entirely reversed by pretreatment with either adeno-associated virus (AAV)-sh or AAV-sh. Collectively, these findings identify AhR deficiency as a key driver of aberrant γδT17 activation, uncover a γδT17 activation mechanism via HSPA9/FBXW11-mediated suppression of NICD ubiquitination, and provide a strong mechanistic basis for AhR agonists as therapeutics in autoimmune inflammations. - Source: PubMed
Publication date: 2026/07/03
He YueGuo YileiShi YuxinWan XuanmingZhu YanrongZhang WenjieLin HaochangWei ZhifengXia YufengDai Yue - Gastric cancer (GC) is a major global health problem, particularly in Asia. Dihydrotanshinone I (DHT), a naturally derived and commercially available compound isolated from Salvia miltiorrhiza, exhibits potential anti-GC activity through the modulation of cancer metabolism. - Source: PubMed
Publication date: 2026/05/06
Nie YunmengBai XingZhang MingsiLiu XiaojuanJiang TaoZhang Guangji - Macrophages can be polarized to various states in physiologic and pathologic microenvironments. The simplified but widely accepted M1/M2 polarization states play contradictory roles in tumor progression. The ubiquitin-proteasome system (UPS), particularly F-box proteins, has been reported to be involved in immune regulation. However, the role of F-box and WD-40 domain protein 11 (FBXW11) on macrophage remains unclear. Here, the effects of FBXW11 on macrophage polarization and anti-tumor function were investigated. The results showed that FBXW11 promoted macrophage proliferation and induced a mild M1 polarization phenotype in the absence of tumor cells. Furthermore, overexpression of Fbxw11 enhanced the M1 polarization of macrophages in tumor co-culture system. Moreover, overexpression of Fbxw11 also enhanced glucose uptake and increased mitochondrial reactive oxygen species (ROS) levels, while reducing the mitochondrial membrane potential (Δψ) in macrophages in tumor co-culture system. Functionally, Fbxw11 overexpression increased the phagocytosis and killing of A20 lymphoma cells. RNA-sequencing analysis revealed that FBXW11 activated critical innate immune pathways, including JAK-STAT, NF-κB, and Toll-like receptor signaling, and upregulated effector molecules such as IL-6 and type I interferons. Collectively, our results reveal that FBXW11 paly a positive role on macrophage M1 polarization and anti-tumor function, which broaden the knowledge about how UPS modulates innate immunity. - Source: PubMed
Publication date: 2026/04/03
Zhang SiqiLi RuiyunXie WanzhenCui XiaoxiLi YifeiZhao HuidiRen QianWang LinaZheng Guoguang