TIMP4 Antibody (Center)
- Known as:
- TIMP4 Antibody (Center)
- Catalog number:
- AP10148c
- Category:
- -
- Supplier:
- Abgen
- Gene target:
- TIMP4 Antibody (Center)
Related genes to: TIMP4 Antibody (Center)
- Gene:
- TIMP4 NIH gene
- Name:
- TIMP metallopeptidase inhibitor 4
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 3p25.2
- Locus Type:
- gene with protein product
- Date approved:
- 1997-07-07
- Date modifiied:
- 2016-10-05
Related products to: TIMP4 Antibody (Center)
Related articles to: TIMP4 Antibody (Center)
- Chronic neuroinflammation has become a major concern due to its ability to propagate into multiple neurodegenerative disorders which severely reduce the life expectancy of the patients. Many molecular targets have been identified which include amyloid beta (Aβ) peptides and oligomers, protofibrils, tau proteins, MID1/ TRIM18, Beclin1 protein, Puma, NMDA receptors, RyanR2, 5-HT2B, α7nAChR, TLR4, ERRα, CysLT(1)R, PDGFβR, DRD1, β2-AR, caspases, calpain, cytochrome c, CDK5, p38-MAPK, BACE1, γ-secretase, 5-lipoxygenase, NADPH oxidase 2 and 4, JNK, MMPs, NLRP3, GSAP, PARP-1, PARG, TRPM2, HO, NO (excess), LTB4, LTD4, NF-κB (NF-kBp50/RelA dimers and NF-κB p65), TNF-α,IL-1β, IL-6, IL-10, ApoE2, ApoE4, Bax,Bcl-2, miR-9, miR-29, miR-29a/b-1, miR-101, miR-124, miR-107, miR-298, miR-149, miR-328, miR-34a-5p, miR-15b, miR-16, miR-125b-5p, miR-124, and miR-374b-5p, miR-181c-5p, linc00507, LncRNA 51A, LncRNA 17A, LncRNA BC200, LncRNA NDM29, LncRNA NEAT1, LncRNA EBF3-AS, LncRNA NAT-Rad18, LcRNA TUG1, LncRNA MALAT1, LncRNA WT1-AS, LncRNA MAGI2-AS3, XBP-1, SERCA, Na/Caexchanger, plasma-membrane Ca-ATPase, HSP27, mtHSP60/HSPD1-mtHSP10/HSPE1, HSPD1, HSPE1, HSP70, Hsp90, Sirt1, Sirt3, TIMP-123 (composite of TIMP-1, TIMP-2, and TIMP-3), TIMP-4, AChEI, BDNF. Identification of the molecular targets enabled the identification of phytoconstituents which could modulate majority of these molecular targets. A herbal formulation which is expected to alleviate neuroinflammation includes many phytoconstituents such as curcumin, (-)-epigallocatechin-3-gallate, baicalein, baicalin, resveratrol, cis-resveratrol, berberine, quercetin, apigenin, corosolic acid, ursolic acid, oleanolic acid, luteolin, albigenin, withanolide A, celastrol, gallotannin, nobotanin B, kaempferol, naringenin, rutin, withaferin A, crocetin, katsumain H, geranylgeranylacetone and huperzine. A compatibility study with different phytoconstituents will determine the suitability of the formulation. - Source: PubMed
Publication date: 2026/05/20
Paul Deepraj - : Atrial fibrillation (AF) is the most common supraventricular arrhythmia and one of the most commonly encountered heart conditions in clinical practice. Emerging evidence suggests a significant role of inflammation, endothelial disfunction and extracellular matrix (ECM) remodeling in the pathogenesis of AF. Population studies have also suggested an association between AF and cerebral small vessel disease (CSVD), with growing evidence indicating that the burden of certain markers of CSVD is greater in women. However, the association between female sex and CSVD remains poorly understood. The aim of this study was thus to investigate the role of female sex in the association between circulating biomarkers and the presence of CSVD in AF patients undergoing oral anticoagulant therapy. : The Strat-AF study is an observational, prospective, single-center, hospital-based study enrolling elderly patients with AF. Results refer to 170 patients (59 women and 111 men). Recruited patients are evaluated by means of a comprehensive protocol, with clinical, cerebral magnetic resonance imaging (MRI) and circulating biomarker assessments. : From a multivariate logistic regression analysis adjusted for multiple confounders, independent predictors were: in women, elevated vWF levels for the presence of lacunar infarcts [OR 3.24 (1.23-8.55), = 0.018], elevated MMP-12, TIMP-1, TIMP-2, and TIMP-4 levels for the presence of CMBs [OR 7.76 (1.60-37.69), = 0.021; OR 1.90 (1.02-3.52), = 0.042; OR 2.46 (1.27-4.80), = 0.008; and OR 2.36 (1.12-4.95), = 0.023, respectively], elevated IL-6 and MMP-2 levels for the presence of WMH [OR 10.65 (1.31-86.67), = 0.027; OR 3.36 (1.23-9.15), = 0.018, respectively] and elevated MMP-12 and TIMP-2 levels for the presence of bgEPVS [OR 2.57 (1.22-5.93), = 0.027; OR 2.15 (1.03-4.53), = 0.043, respectively]; and in men: elevated TIMP-1 levels for the presence of WMH [OR 2.10 (1.08-4.08), = 0.030], elevated TIMP-1 levels for the presence of bgEPVS [OR 2.20 (1.11-4.38), = 0.025] and elevated TIMP-1 levels for SVDs positivity [OR 7.25 (2.18-24.15), = 0.001]. : These results from the Strat-AF study demonstrated that a complete biohumoral and instrumental assessment can jointly identify female patients with AF at higher risk of CSVD. These findings pave the way for the implementation of clinical protocols incorporating brain MRI and circulating biomarkers as potential innovative tools for an increasingly refined-and sex-specific-stratification of cardiovascular risk in AF patients undergoing oral anticoagulant therapy. - Source: PubMed
Publication date: 2026/06/08
Alfano FrancescoBerteotti MartinaCesari FrancescaGori Anna MariaSalvadori EmiliaGiusti BettiBertelli AlessiaBicchi LucaFratini FilippoFormelli BenedettaBarucci EleonoraSalti GiuliaFainardi EnricoGinestroni AndreaChiti StefanoPoggesi AnnaMarcucci Rossella - Despite effective combination antiretroviral therapy (cART), executive function impairment remains prevalent among people living with HIV (PLWH). The pathogenesis of HIV-associated neurocognitive disorder is multifactorial, involving chronic immune activation, metabolic alterations, and neuroinflammatory processes. Matrix metalloproteinases and their tissue inhibitors (TIMPs) contribute to neuroinflammation and blood-brain barrier disruption, but their relationship with executive dysfunction in HIV remains unclear. - Source: PubMed
Publication date: 2026/06/03
Weng Ya-WeiTsai Hung-ChinLee Susan Shin-JungHsu Chih-HuiLin Sheng-Hsiang - Intramuscular fat (IMF) plays an important role in determining meat quality traits such as flavor, tenderness, and juiciness. While numerous studies have investigated the genetic basis of IMF in commercial pig breeds, data on local breeds remain rather limited. In this study, we used RNA-sequencing to characterize the transcriptomic differences between high-IMF and low-IMF Black Slavonian pigs, a native Croatian breed known for superior meat quality. Muscle samples (Longissimus thoracis et lumborum) from 14 pigs with divergent IMF levels were collected shortly after slaughter, preserved in liquid nitrogen, and stored at - 80 °C until RNA extraction. Intramuscular fat content was determined from the same muscle 24 h post mortem using the Soxhlet extraction method (ISO 1443:1973). These samples were then analyzed to identify differentially expressed genes (DEGs) and enriched pathways. A total of 519 genes were differentially expressed (p ≤ 0.05), with 457 remaining significant after false discovery rate correction. The high-IMF group exhibited upregulation of genes associated with lipid metabolism (e.g., SCD, ADIPOQ, CIDEC, FABP4), PPAR signaling, and adipogenesis, while genes linked to muscle structure and oxidative metabolism were downregulated. Functional enrichment and gene set enrichment analyses highlighted coordinated regulation of pathways related to fatty acid biosynthesis, extracellular matrix (ECM) remodelling, angiogenesis, and Notch signaling. Notably, several ECM-related genes (LAMA1, TIMP4) and angiogenic factors (FGF2, NRP1) were significantly upregulated, suggesting that adipocyte expansion in muscle requires parallel vascular and structural adaptations. Importantly, several of the top 30 DEGs, including EHD2, NRG4, UTRN, FLNA, and HMCN1, represent novel candidate genes not previously linked to IMF in pigs, pointing to potential breed-specific mechanisms. These genes are associated with membrane trafficking, paracrine signalling, cytoskeletal re-modelling, and ECM dynamics. Our findings contribute new molecular insights into IMF regulation in local pig breeds and provide a foundation for developing targeted breeding strategies to improve pork quality through intramuscular fat enhancement. - Source: PubMed
Publication date: 2026/05/20
Lukic BorisLipavić GoranBulaić MatejaIno CurikRadišić ŽarkoLužaić RasRaguž Nikola - Bothrops envenomation induces extensive local tissue destruction and a robust inflammatory response, largely driven by the host's endogenous molecular pathways. Among these, Matrix Metalloproteinases (MMPs), zinc-dependent endopeptidases responsible for extracellular matrix (ECM) degradation, play a central role. The clinical severity of envenomation is therefore strongly influenced by the balance between MMPs and their specific inhibitors, the TIMPs. This study investigated the contribution of MMP-1, MMP-2, MMP-7, MMP-9, and MMP-10 and TIMP-1, TIMP-2, TIMP-3, and TIMP-4 to the inflammatory response following Bothrops snakebites. - Source: PubMed
Publication date: 2026/04/24
Ferreira Neves Juliana CostaMagalhães-Gama FábioIbiapina Hiochelson Najibe SantosSeixas Kamille BeltrãoBarbosa Êndila SouzaMalheiro AdrianaSachett Jacqueline Almeida GonçalvesCampi-Azevedo Ana CarolinaMartins-Filho Olindo AssisTeixeira-Carvalho AndréaSartim Marco AurélioMonteiro WueltonCosta Allyson Guimarães