BOTTLE,DROPPING,AMB,PLAS DROPPER,60ML
- Known as:
- BOTTLE,DROPPING,AMB,PLAS DROPPER,60ML
- Catalog number:
- 15040P-60
- Product Quantity:
- Case Qty: 12 x 10
- Category:
- -
- Supplier:
- Kleinfeld Labo
- Gene target:
- BOTTLE DROPPING AMB PLAS DROPPER 60ML
Related genes to: BOTTLE,DROPPING,AMB,PLAS DROPPER,60ML
- Gene:
- LCP1 NIH gene
- Name:
- lymphocyte cytosolic protein 1
- Previous symbol:
- -
- Synonyms:
- PLS2, CP64, L-PLASTIN, LC64P
- Chromosome:
- 13q14.13
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2016-10-05
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- Microfluidic platforms have emerged as powerful tools for investigating complex interactions between cells and their microenvironment. Conventional cancer models often fail to accurately replicate the complexities of the tumor microenvironment. In contrast, cancer-metastasis-on-a-chip models integrate the benefits of three-dimensional cell cultures with microfluidic technology, providing more physiologically relevant platforms for studying cancer biology and improving precision of drug screening. These platforms enable the compartmentalization of the metastatic cascade, allowing for more detailed understanding of its fundamental mechanisms. In this study, we employed an advanced microfluidic cancer-on-a-chip model to examine the invasion dynamics of SKOV3 ovarian cancer cells under fibrotic conditions. Specifically, we assessed the therapeutic efficacy of bevacizumab in combination with siRNA targeting , , and -genes previously identified as upregulated and implicated in enhanced invasion during the progression from non-resistant (Non-R) SKOV3 to carboplatin-resistant (Carbo-hR) variants. Our results demonstrated a modest increase in invasive behavior in Non-R SKOV3 cells within the fibrotic microenvironment. In contrast, Carbo-hR cells exhibited dramatically increased invasion and a strong metastatic affinity for fibrotic lung tissue. Monotherapy with bevacizumab showed limited efficacy in Carbo-hR cells compared to non-R cells. However, the combined treatment with bevacizumab and siRNA targeting , , and substantially suppressed the invasive capacity of Carbo-hR cells, effectively restoring their phenotype to that of non-R cells. These findings highlight the promise of combining anti-angiogenic agents with targeted gene silencing strategies to overcome drug resistance and inhibit metastasis, particularly within fibrotic tumor microenvironments. - Source: PubMed
Publication date: 2025/08/23
Hwang Sun-YoungLee DanbiLee Yu-GyeongAhn JunghoKang Youn-Jung - Six compounds were isolated from the fermentation broth of Roussoella sp. LCP1-2, including four new metabolites: papyracillic acid D (1), 7-epi-4-epi-papyracillic acid B (2), 4-epi-papyracillic acid B (3), and 3-hydroxyl-11α,18-Dihydroxy-7-oxo-13-epi-ent-pimara-8(9),15-diene (5), along with two known compounds, papyracillic acid B (4) and saccharonol A (6). Their planar structures were elucidated through comprehensive analysis of NMR and MS spectroscopic data. The structure of 1 was unambiguously confirmed by single-crystal X-ray diffraction analysis. The absolute configurations of compounds 2, 3, and 5 were established through a combination of experimental ECD spectroscopy and computational ECD calculations. Biological evaluation revealed that compound 3 exhibited moderate proangiogenic activity in a zebrafish model at a concentration of 40 μM. - Source: PubMed
Publication date: 2025/08/19
Wei CaixiaSun JianTian JingyuanShu TingWu RongxiangHao YiCheng KexinWang CongKong FandongZhou Liman - Deciphering the intricate regulatory mechanisms underlying biological processes holds promise for elucidating how genetic variants contribute to immune-related disorders. We map genetic effects on gene expression (expression quantitative trait locus, eQTL) using single-cell transcriptomes of 152 samples from 38 healthy individuals, covering baseline state and lipopolysaccharide challenge either before or after Bacillus Calmette-Guerin vaccination. Interestingly, we uncover a monocyte eQTL linked to the LCP1, shedding light on inter-individual variations in trained immunity. Furthermore, we elucidate genetic and epigenetic regulatory networks of CD55 and SLFN5. Of note, our results support the pivotal roles of SLFN5 in COVID-19 pathogenesis by incorporating disease-associated loci, chromatin accessibility, and transcription factor binding affinities, aligning with the established functions of SLFN5 in restricting virus replication during viral infection. Our study provides a paradigm to decipher genetic underpinnings of complex traits by integrating single-cell eQTLs with multi-omics data from patients and public databases. - Source: PubMed
Publication date: 2025/08/04
Zhang ZhenhuaLi WenchaoZhan QiuyaoAillaud MichelleBotey-Bataller JavierZoodsma MartijnTer Horst RobJoosten Leo A BBock ChristophSchulte Leon NXu Cheng-JianNetea Mihai GBonder Marc JanLi Yang - Lactic acid is a by-product of energy metabolism and a signaling molecule that influences tumor progression by regulating immune cell function, angiogenesis, and epigenetic modifications. - Source: PubMed
Publication date: 2025/07/16
Tang YanliangZhang XiaoliTang XiaofeiYuan YeWang Wenwen - Previously, we demonstrated that the ketone body, β-hydroxybutyrate, is a potent antihypertensive and reno-protective metabolite in Dahl Salt-Sensitive rats. However, the mechanism by which β-hydroxybutyrate confers these beneficial effects is understudied. Here we focused on determining whether the reno-protective effect of β-hydroxybutyrate is due to its known ability to epigenetically remodel chromatin via histone β-hydroxybutyrylation. - Source: PubMed
Publication date: 2025/07/29
Mandal JuthikaAryal SachinManandhar IshanChakraborty SarojMei XueYeoh Beng SanMell BlairKleinhenz AndrewTummala RamakumarYang TaoSaha PiuGunning William TVijay-Kumar MatamBasrur Venkateshade la Serna IvanaJoe Bina