Confocal Dish,PP,hole punched,35x10mm,coverglass(22x22x0.13mm)adhesion type, easy grip,TC treated, Sterile to SAL10-6,5_50_case
- Known as:
- Confocal Dish,PP,hole punched,35x10mm,coverglass(22x22x0.13mm)adhesion classification, easy grip,TC treated, Sterile SAL10-6,5_50_case
- Catalog number:
- 200350
- Product Quantity:
- x 5
- Category:
- -
- Supplier:
- SPL
- Gene target:
- Confocal Dish hole punched 35x10mm coverglass(22x22x0.13mm)adhesion type easy grip treated Sterile SAL10-6 5_50_case
Related genes to: Confocal Dish,PP,hole punched,35x10mm,coverglass(22x22x0.13mm)adhesion type, easy grip,TC treated, Sterile to SAL10-6,5_50_case
- Gene:
- TMEM121 NIH gene
- Name:
- transmembrane protein 121
- Previous symbol:
- -
- Synonyms:
- MGC4659, hole, TMEM121A
- Chromosome:
- 14q32.33
- Locus Type:
- gene with protein product
- Date approved:
- 2006-02-15
- Date modifiied:
- 2017-06-22
Related products to: Confocal Dish,PP,hole punched,35x10mm,coverglass(22x22x0.13mm)adhesion type, easy grip,TC treated, Sterile to SAL10-6,5_50_case
Related articles to: Confocal Dish,PP,hole punched,35x10mm,coverglass(22x22x0.13mm)adhesion type, easy grip,TC treated, Sterile to SAL10-6,5_50_case
- The Zhuang, China's largest ethnic minority with over 17 million individuals, represent a critical yet understudied population for understanding East Asian genetic diversity and population history. Here, we present the first high-coverage whole-genome (>30×) and exome (>70×) sequencing study of the Zhuang (ZUN), integrating ancient and modern genomic data to reconstruct their evolutionary trajectory. We show that ZUN derive ∼68% of their ancestry from the Tai-Kadai-speaking people, diverging ∼3,000 to 5,000 years ago (ya), with the Maonan as their closest genetic relatives. Our analyses support a shared origin of Tai-Kadai and Austronesian populations ∼7,000 ya, predating their divergence from Sino-Tibetan groups ∼16,000 ya. Substantial gene flow from Han Chinese since ∼4,000 ya reduced genetic divergence between ZUN and northern East Asians to ∼12,000 years. The ZUN ancestral gene pool formed 5,000 to 3,000 ya through multiple admixture waves, with 87% contribution from southern populations and 12% from northern groups. Demographic modeling indicates continuous population expansion until ∼10,000 ya, followed by a pronounced growth surge over the past 400 years. Adaptive selection signatures highlight genes linked to immune response (IGH cluster), lipid metabolism (FADS1/2), wound healing (TMEM121), and environmental adaptation (ABCC11), suggesting dietary shifts and tropical pathogens as key evolutionary drivers. Furthermore, the ZUN genetic profile reflects their role as a regional hub for gene flow into neighboring populations, coinciding with Han migrations during the Qin dynasty. Together, these results identify the Zhuang as descendants of Baiyue populations with a distinctive dual ancestry shaped by Neolithic southern and northern East Asians. - Source: PubMed
Mao ChuangxueLi SongyangLu YanLiu QiDeng LianGao YangZhang XiaoxiChen HaoYang YajunXu Shuhua - TMEM121 is a six-pass transmembrane protein consisting of an N-terminal transmembrane domain (TD; residues 1-284) and a C-terminal polyproline sequence (PP; residues 284-319). In this study, publicly accessible databases were utilized to ascertain that TMEM121 correlates with various cytokines associated with the MAPK signaling pathway in cervical cancer. Furthermore, TMEM121 expression was negatively correlated with ERK expression in cervical cancer tissues. Protein interaction prediction using AlphaFold3 suggested an interaction between TMEM121 and ERK1/2, which was experimentally validated through Co-immunoprecipitation and immunofluorescence analyses. Both full-length TMEM121 and the TD truncator interacted with ERK and downregulate p-ERK1/2 protein levels, thereby inhibiting the proliferation and invasion of cervical cancer cells. In contrast, the PP truncator did not exhibit these effects. RNA-seq analysis further confirmed a significant association between TMEM121 and the MAPK signaling pathway in cervical cancer. Additionally, flow cytometry analysis showed that the ERK inhibitor PD98059 reversed the S phase cell cycle arrest induced by TMEM121 overexpression. Collectively, these findings suggest that TMEM121 exerts its inhibitory effects on the growth, proliferation, and invasion of cervical cancer cells through its interaction with ERK, providing a theoretical basis for the development of novel diagnostic and therapeutic strategies for cervical cancer. - Source: PubMed
Publication date: 2026/01/15
Wang HaochenXu SitingLi SihuiLin MeiJiao ZhongbeiZhao JialinWu DanHuang YanliLiu SiyuanGe ShanyanWu XiushanLi FangGuo LiluFan Xiongwei - Immunoglobulin (Ig) glycosylation modulates the immune response and plays a critical role in ageing and diseases. Studies have mainly focused on IgG glycosylation, and little is known about the genetics and epidemiology of IgA glycosylation. - Source: PubMed
Publication date: 2024/08/09
Visconti AlessiaRossi NiccolòBondt AlbertEderveen Agnes HipgraveThareja GauravKoeleman Carolien A MStephan NishaHalama AnnaLomax-Browne Hannah JPickering Matthew CZhou Xu-JieWuhrer ManfredSuhre KarstenFalchi Mario - Transmembrane protein 121 (TMEM121) is isolated from the chicken heart using subtraction hybridisation. A previous study by the authors indicated that TMEM121 is highly expressed in adult mouse hearts and acts as an inhibitor of pathological cardiac hypertrophy. In the present study, the association between TMEM121 and cancer was investigated using bioinformatics tools, including Tumour Immune Estimation Resource (TIMER) 2.0, cBioPortal, LinkedOmics analysis, Kaplan-Meier plotter and UALCAN analysis. The expression, genetic variation, gene interaction network and co-expression pattern of in tumours were analysed. The results revealed that was expressed in various tumours and significantly downregulated in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) when compared with its expression in paracancerous tissues, whereas the methylation level of its promoter was increased in tumour tissues. Additionally, associations between TMEM121 and the PI3K/AKT signalling pathway, as well as the expression of cancer-related molecules, were detected. The aforementioned bioinformatics analysis suggests that TMEM121 may be involved in the development of cervical cancer. Therefore, gain-of-function and loss-of-function experiments in HeLa cells were conducted to verify the role of TMEM121 in cervical cancer. The assay using Cell Counting Kit-8 (CCK-8) revealed that the cell viability of HeLa cells with TMEM121 overexpression was significantly reduced. High TMEM121 expression inhibited HeLa cell migration, as indicated by the decrease in the cell scratch healing rate. The western blot assay revealed that overexpression downregulated the expression of B-cell lymphoma 2 (BCL-2), cyclin D1, cyclin E2 and phosphorylated (p)-AKT, while upregulating that of p27, E-cadherin and p-p38. When was knocked down, retinoblastoma protein (RB), p53, p27, E-cadherin, p-JNK and p-p38 were inhibited, but cyclin E1 was promoted. By combining bioinformatics and experimental biology in the present study, the results demonstrated for the first time, to the best of our knowledge, that TMEM121 may be a novel inhibitor of cervical cancer that is linked to multiple signalling pathways, paving the way for the development of novel diagnostic and therapeutic strategies. - Source: PubMed
Publication date: 2022/07/15
Yang BoyuCai YiZhu PingJiang ZhigangAo JieyuZhang QingYuan WuzhouPeng ZhilinChen JimeiWen YaoChen YuWang YuequnShi YanZhu XiaolanYe XiangliLi FangZhuang JianWu XiushanLi YongqingFan Xiongwei - Prostate cancer (PCa) is a leading cause of cancer-related deaths among men worldwide, and novel therapies for advanced PCa are urgently needed. Cardiac glycosides represent an attractive group of candidates for anticancer repurposing, but the cardiac glycoside deslanoside has not been tested for potential anticancer activity so far. We found that deslanoside effectively inhibited colony formation in vitro and tumor growth in nude mice of PCa cell lines 22Rv1, PC-3, and DU 145. Such an anticancer activity was mediated by both the cell cycle arrest at G2/M and the induction of apoptosis, as demonstrated by different functional assays and the expression status of regulatory proteins of cell cycle and apoptosis in cultured cells. Moreover, deslanoside suppressed the invasion and migration of PCa cell lines. Genome-wide expression profiling and bioinformatic analyses revealed that 130 genes were either upregulated or downregulated by deslanoside in both 22Rv1 and PC-3 cell lines. These genes enriched multiple cellular processes, such as response to steroid hormones, regulation of lipid metabolism, epithelial cell proliferation and its regulation, and negative regulation of cell migration. They also enriched multiple signaling pathways, such as necroptosis, MAPK, NOD-like receptor, and focal adhesion. Survival analyses of the 130 genes in the TCGA PCa database revealed that 10 of the deslanoside-downregulated genes (, , , , , , , , , and ) inversely correlated, while one deslanoside-upregulated gene () positively correlated, with disease-free survival in PCa patients. In addition, one deslanoside-downregulated gene () inversely correlated, while three upregulated genes (, , and ) positively correlated with overall survival in PCa patients. Some of the 15 genes have not been implicated in cancer before. These findings provide another candidate for repurposing cardiac glycosides for anticancer drugs. They also suggest that a diverse range of molecular events underlie deslanoside's anticancer activity in PCa cells. - Source: PubMed
Publication date: 2021/11/19
Liu MingchengHuang QingqingA JunLi LinyueLi XiaweiZhang ZhiqianDong Jin-Tang