Antibody: CD1a, Clone: HI149 , Isotype: IgG1, Conjugate: CF-BlueTM
- Known as:
- Antibody: CD1a, Clone: HI149 , Isotype: IgG1, Conjugate: CF-BlueTM
- Catalog number:
- 1ACFB-100T
- Product Quantity:
- 100 test
- Category:
- -
- Supplier:
- Immunostep
- Gene target:
- Antibody: CD1a Clone: HI149 Isotype: IgG1 Conjugate: CF-BlueTM
Related genes to: Antibody: CD1a, Clone: HI149 , Isotype: IgG1, Conjugate: CF-BlueTM
- Gene:
- CD1A NIH gene
- Name:
- CD1a molecule
- Previous symbol:
- CD1
- Synonyms:
- -
- Chromosome:
- 1q23.1
- Locus Type:
- gene with protein product
- Date approved:
- 1988-05-11
- Date modifiied:
- 2017-07-07
Related products to: Antibody: CD1a, Clone: HI149 , Isotype: IgG1, Conjugate: CF-BlueTM
Related articles to: Antibody: CD1a, Clone: HI149 , Isotype: IgG1, Conjugate: CF-BlueTM
- Myeloid/lymphoid neoplasms with FGFR1 rearrangement (MLN-FGFR1), also known as 8p11 myeloproliferative syndrome, are rare and aggressive hematologic malignancies arising from pluripotent stem cells. The FGFR1::ZMYM2 fusion resulting from t(8;13)(p11.2;q12) characteristically co presents as T-lymphoblastic lymphoma in lymph nodes alongside a myeloproliferative neoplasm in the bone marrow. The disease is resistant to tyrosine kinase inhibitors and conventional chemotherapy, and carries a median survival of less than 12 months without allogeneic hematopoietic stem cell transplantation (allo-HSCT). : We report a 23-year-old female who presented with progressive cervical lymphadenopathy and hyperleukocytosis (WBC 186.6 K/μL). Excisional lymph node biopsy demonstrated T-cell acute lymphoblastic lymphoma (T-ALL) with eosinophilic infiltration; immunohistochemistry confirmed lymphoblasts positive for CD1a, CD2, CD3, CD4, CD5, CD7, CD8, and TdT. Concurrent bone marrow biopsy showed a myeloproliferative neoplasm without excess blasts. Chromosomal analysis confirmed t(8;13)(p11.2;q12) with FGFR1::ZMYM2 rearrangement, and NGS identified a concurrent CSF3R variant (Q741*). She received induction chemotherapy per the PEDS AALL1231 protocol (Arm A) followed by consolidation, with a course complicated by hyperleukocytosis, venous thromboembolism, bacteremia, and severe mucositis requiring PICU admission. Despite initial response, the disease progressed to acute myeloid leukemia (AML) with acquisition of a PTEN variant; the patient was offered but did not complete allo-HSCT and died of refractory AML approximately 10 months after diagnosis. : This case highlights the aggressive clinical course and diagnostic challenges of MLN-FGFR1, a rare stem cell-derived myeloid/lymphoid neoplasm. To our knowledge, this appears to be the first reported case documenting sequential CSF3R and PTEN variant acquisition with complete follow-up through fatal AML transformation, and the first to describe treatment with a pediatric ALL induction protocol (PEDS AALL1231) in this setting. The characteristic histomorphologic pattern of eosinophil-rich T-ALL in lymph nodes with concurrent myeloproliferative neoplasm in bone marrow should prompt immediate molecular workup. Allo-HSCT must be pursued urgently at diagnosis, as complications rapidly narrow the transplant window and the disease is uniformly fatal without it. - Source: PubMed
Publication date: 2026/08/06
Krishnareddigari MehaPatel GopalBokhari AqibaGraff John PaulDwyre Denis MPanigrahi Arun - Erdheim-Chester disease (ECD) is one of 3 major types of histiocytic neoplasms, along with Rosai-Dorfman disease and Langerhans cell histiocytosis. It was first recognized as a neoplasm in the 2016 World Health Organization Classification of Haematolymphoid Tumours. About 80% to 90% of cases harbor MAPK pathway mutations. - Source: PubMed
Ravindran AishwaryaRech Karen L - Rosai-Dorfman disease (RDD) is a rare non-Langerhans cell histiocytosis that typically presents with nodal disease in young males. Extranodal involvement occurs less frequently and may involve the nasal cavity, paranasal sinuses, or orbit. Airway involvement is particularly uncommon, and simultaneous sinonasal and subglottic disease is exceptionally rare. We describe a 39-year-old female presenting with progressive nasal obstruction, throat fullness, and hoarseness. Nasal endoscopy demonstrated bilateral polypoidal tissue, while flexible laryngoscopy revealed a posterior subglottic nodule. Computed tomography showed diffuse sinonasal disease and a subglottic soft-tissue lesion without bony erosion. Histopathology confirmed RDD through characteristic emperipolesis and an S100+/CD68+/CD1a- immunophenotype. Treatment with systemic corticosteroids resulted in rapid improvement with near-complete resolution of both lesions. This case presents a highly unusual anatomical distribution of RDD with significant clinical teaching value, representing the first such report in Saudi Arabia. Awareness of this presentation may prevent misdiagnosis and unnecessary surgical intervention. - Source: PubMed
Publication date: 2026/08/19
Almohammadi Nawal HAlhejaili MohamedAljazei Fawaz AAbdelsalam Hesham - Destombes-Rosai-Dorfman (DRD) disease was first described in 1965 by the pathologist Paul Destombes. Almost 90% of patients show lymph-node involvement, which is usually cervical, although all organs can be affected. - Source: PubMed
Publication date: 2026/08/18
Righini C-AGil HSpinelli A - Pulmonary crystal-storing histiocytosis (CSH) without an associated haematological malignancy, lymphoproliferative disorder, plasma cell disorder, or other identifiable underlying condition is exceptionally rare. Long-term radiological data from published cases remain limited, and this case, contextualised by a narrative review of the literature, may expand the recognised imaging spectrum of localised pulmonary CSH. We report the case of a 59-year-old man with incidental multiple pulmonary lesions identified on CT thorax imaging. The lesions demonstrated an unusual combination of cystic change, cavitation, and surrounding ground-glass opacities. His medical history was significant for bipolar disorder treated with lithium and a 50-pack-year smoking history. Interval imaging showed progression, prompting further investigation and ultimately right upper lobectomy. Histopathological analysis confirmed pulmonary CSH; lesional cells contained crystalloid material and showed CD68 and PAS positivity, with dual kappa and lambda expression on immunohistochemistry. Markers for other differential diagnoses, including Congo red, birefringence, Langerin, and CD1a were negative. Following diagnosis and resection, serial imaging demonstrated fluctuating yet slowly progressive pulmonary abnormalities. No lymphoproliferative or plasma cell disorder has emerged after more than seven years of post-diagnostic surveillance and more than ten years since the initial imaging abnormality. This case demonstrates that the radiological spectrum of localised pulmonary CSH may include cystic, cavitary and ground-glass abnormalities, with subsequent fluctuating yet slowly progressive post-resection evolution. Pulmonary CSH should be considered in the differential diagnosis of unexplained or atypical pulmonary nodules, particularly when histiocyte-rich pathology with intracytoplasmic crystalloid material is identified. Long-term multidisciplinary surveillance is warranted. - Source: PubMed
Publication date: 2026/07/31
Halim DzufarMcGrath ErinnAmpazis DimitriosKrawczyk JanuszShatwan RamadanO'Regan Anthony