Antibody: CD1a, Clone: HI149 , Isotype: IgG1, Conjugate: Biotin
- Known as:
- Antibody: CD1a, Clone: HI149 , Isotype: IgG1, Conjugate: Biotin
- Catalog number:
- 1AB-01MG
- Product Quantity:
- 0,1mg
- Category:
- -
- Supplier:
- Immunostep
- Gene target:
- Antibody: CD1a Clone: HI149 Isotype: IgG1 Conjugate: Biotin
Related genes to: Antibody: CD1a, Clone: HI149 , Isotype: IgG1, Conjugate: Biotin
- Gene:
- CD1A NIH gene
- Name:
- CD1a molecule
- Previous symbol:
- CD1
- Synonyms:
- -
- Chromosome:
- 1q23.1
- Locus Type:
- gene with protein product
- Date approved:
- 1988-05-11
- Date modifiied:
- 2017-07-07
Related products to: Antibody: CD1a, Clone: HI149 , Isotype: IgG1, Conjugate: Biotin
Related articles to: Antibody: CD1a, Clone: HI149 , Isotype: IgG1, Conjugate: Biotin
- Primary biliary cholangitis (PBC) is an immune-mediated cholangiopathy for which ursodeoxycholic acid (UDCA) improves biochemical outcomes and survival, but its effects on tissue phenotype remain uncertain. We examined whether morphology and marker expression change with UDCA status or primarily reflect disease severity. - Source: PubMed
Publication date: 2026/09/15
Khurram Nigar AnjumanStanton KarleneMiller AlexanderVarshney NehaBarwad AdarshSharma Chhagan BihariBaroudi IhsanDavis KoraMcGrath NathanZhang Paul J L - T-lymphoblastic leukemia/lymphoma (T-ALL/LBL) is an aggressive neoplasm of immature T-lymphoid precursors that is classified as T-cell acute lymphoblastic leukemia when the primary site of involvement is the bone marrow and peripheral blood and as T-cell lymphoblastic lymphoma when it presents as a solid mass, most commonly in the anterior mediastinum. The neoplastic cells are defined by expression of T-lineage antigens (cytoplasmic or surface CD3) together with one or more markers of immaturity (terminal deoxynucleotidyl transferase, CD1a, CD34, CD99, or CD117) and must not fulfill criteria for early T-cell precursor acute lymphoblastic leukemia (ALL). This entity shows a marked male predominance (male:female ≈ 2:1) and predominantly affects children, adolescents, and young adults, accounting for approximately 15% of childhood ALL and 20%-25% of adult ALL cases. Pathologic diagnosis increasingly relies on recurrent molecular alterations such as activating NOTCH1 mutations (>60% of cases), transcription factor rearrangements, and cell-cycle regulator inactivation. Although intensive multiagent chemotherapy regimens have substantially improved outcomes, particularly in pediatric patients, adults and high-risk molecular subgroups continue to experience inferior survival. This review provides a practical, pathology-oriented update on the epidemiology, pathogenesis, diagnostic criteria, differential diagnosis, prognostic factors, and current treatment approaches for T-ALL/LBL. - Source: PubMed
Publication date: 2026/09/15
Danielson DavidLagerstrom Ian TRogers MaxSimon KyleAguilera Nadine SAuerbach Aaron - Indeterminate cell histiocytosis (ICH) is a clonal proliferative disorder of mononuclear phagocyte cells that shows features of both dendritic and histiocytic cells. Only around 100 cases of ICH were reported, and among them, only 24% of reported cases involve pediatric patients, with a mean age at diagnosis of 50 years. We report an exceptionally rare case of solitary ICH in a 4-year-old boy. A 4-year-old visited our department presenting a solitary asymptomatic bean-sized reddish nodule on upper abdomen for 1 year. Initially thought to be keloid or dermatofibroma, an excisional biopsy was performed. Histopathological examination revealed dense cellular infiltration in the dermis, characterized by medium-sized mononuclear histiocytes displaying abundant glassy eosinophilic cytoplasm and indented or folded nuclei. Immunohistochemistry studies confirmed positivity for S-100 protein and CD1a, coupled with negativity for CD207/Langerin. Electron microscopy revealed the absence of Birbeck granules, leading to the diagnosis of ICH. With no remarkable findings in laboratory and imaging studies, the patient is undergoing regular follow-up to monitor any potential recurrence or development of related conditions. While most cases of skin-restricted ICH follow an indolent course, recognizing the reported association between ICH and other hematologic neoplasms is crucial. Therefore, awareness of ICH is essential, and in cases of suspicion, a skin biopsy should be performed for an accurate diagnosis. - Source: PubMed
Publication date: 2026/09/13
Lee Seung-SooLee Seok-JongLee Weon JuHa Dae-Lyong - Rosai-Dorfman-Destombes disease (RDD) is a rare histiocytic disorder characterized by the accumulation of abnormal histiocytes in nodal and extranodal tissues. We report a 24-year-old male presenting with progressive right distal thigh pain for 1 month. MRI demonstrated a 3.5 cm intramedullary lesion in the distal right femoral metadiaphysis with minimal periosteal edema, raising concern for malignancy. Staging CT scans showed no evidence of metastatic disease. Biopsy of this lesion revealed the characteristic accumulation of CD1a-negative and S100-positive histiocytes with emperipolesis, consistent with RDD. Subsequently, PET/CT scan demonstrated multifocal osseous disease involving at least 4 sites, involving the distal right femur (SUVmax 9.0), left humerus (SUVmax 9.7), L4 vertebra, and sacrum, along with 2 cutaneous lesions and possible tonsillar and cervical lymph node involvement. The patient was initiated on the MEK inhibitor cobimetinib and follow-up PET/CT demonstrated complete metabolic resolution of the previously identified osseous disease after approximately 3 months. RDD should be considered in the differential diagnosis when imaging demonstrates concerning osseous lesions in young adults, as definitive diagnosis relies on histopathological evaluation. - Source: PubMed
Publication date: 2026/09/02
Aldubaiyan Khaled WAlRehaily Haniyya AAlJarie Mohammed AAlabdulkareem Omar AAlzahrani Abdullah MAldahlawi Abdulrahman AAlhumaydhi Abdulrahman OAlsalman Mohammed J - Langerhans Cell Histiocytosis (LCH) is a haematological malignancy characterized by the clonal Langerhans cells proliferation. There is paucity of data on adult patients with LCH in India. We reviewed 18 patients of Adult Non-Pulmonary LCH treated at our institute from 2019 to 2024. Their Clinico-pathological features, treatment given and survival were studied. Median age at diagnosis was 30 years. 61% were males. 61% patients presented with bone lesions and 50% with lymphadenopathy. Immuno-Histochemistry (IHC) for CD1a, S100 were positive in all cases. 20% of the tested patients were positive for BRAF V600E mutation. 61% cases were multisystem LCH. Diabetes insipidus was seen in 4 patients (22%). 2 patients underwent curettage of the bone, 1 received radical Radiation therapy. 15 received systemic treatment: 9 received Vinblastine-prednisolone (LCH-3 Protocol) and 6 received cytarabine. Overall response rate was 78%. Median progression free survival was 34 months and median overall survival not reached after a median follow up of 42 months. This study adds to the few case reports of Adult LCH among Indian patients and helps in better understanding of their presentation and responses to therapy. Cytarabine and LCH 3 protocol show good long-term survival in Indian patients. - Source: PubMed
Publication date: 2026/01/05
Rudresha A HMaleyur Vivek BAsutkar Kartik GSureshBabu M CLokesh K NRajeev L KSmitha C SGiri G VPriya DJacob Linu A