AMBP | Alpha_1_microglobulin ( BN11.10)
- Known as:
- AMBP | Alpha_1_microglobulin ( BN11.10)
- Catalog number:
- AS01013
- Product Quantity:
- 100 ug
- Category:
- -
- Supplier:
- Agris
- Gene target:
- AMBP | Alpha_1_microglobulin ( BN11.10)
Related genes to: AMBP | Alpha_1_microglobulin ( BN11.10)
- Gene:
- AMBP NIH gene
- Name:
- alpha-1-microglobulin/bikunin precursor
- Previous symbol:
- ITI, ITIL
- Synonyms:
- UTI, HCP, EDC1, HI30, IATIL, ITILC
- Chromosome:
- 9q32
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2016-10-05
Related products to: AMBP | Alpha_1_microglobulin ( BN11.10)
Related articles to: AMBP | Alpha_1_microglobulin ( BN11.10)
- This letter comments on the study by Ge . Serum α1-microglobulin (α1-MG) was reported to be associated with diabetic nephropathy, retinopathy, peripheral neuropathy, and left ventricular hypertrophy. The letter further highlights the need for multicenter validation and evaluation of clinical applicability to clarify the role of α1-MG in diabetes management. - Source: PubMed
Liao LiLuo AnZhang Long-HanPan Yi-TingLiu Ya-Qing - Loop diuretics require functioning kidney tubules to increase the excretion of sodium into urine thereby relieving congestion in patients with acute heart failure (AHF). Whether biomarkers of kidney tubular health are associated with the natriuretic response of loop diuretics in AHF is unknown. - Source: PubMed
Publication date: 2025/12/11
Wettersten NicholasDuff StephenHoriuchi Yuvan Veldhuisen Dirk JRaturi SagarEstrella Michelle MShlipak Michael GMaisel AlanMurray Patrick TIx Joachim - Cerebral ischemia arises from insufficient blood flow to the brain, resulting in substantial metabolic disturbances. Baicalin, a flavonoid compound derived from Scutellaria baicalensis, has anti-inflammatory, antioxidant, and neuroprotective properties. - Source: PubMed
Son Hyun-KyoungPark Dong-JuKim Hun-HwanKang Ju-BinKoh Phil-Ok - Severe acute pancreatitis (SAP) involves dynamic shifts from inflammation to immunosuppression, where peptidomic profile evolution may reveal prognostic biomarkers. Here, the plasma peptidome of rats with taurocholate-induced SAP at 1, 3, 6, 12, and 24 h compared with controls was characterized using nLC-MS/MS. Ten peptides derived from eight precursor proteins were differentially regulated across time points. The 12-h period showed eight differentially regulated peptides, while the 6- and 24-h periods had four differentially regulated peptides, and one peptide was regulated between 1 and 3 h. Peptides derived from alpha-1-microglobulin (A1M) increased from 3 h onward, while peptides from actin showed major alterations at 12-24 h, coinciding with peak mortality (46%). Bioinformatic enrichment analyses revealed transient activation of mTOR, JAK/STAT, and cell adhesion pathways at 6 h, followed by bacterial invasion and actin cytoskeleton regulation pathways at later stages. These temporal profiles suggest an early antioxidant response and subsequent structural and infection-related remodeling. These findings suggest that A1M-derived peptides could represent potential early indicators of disease severity, although further validation in human clinical settings is required. These findings highlight the plasma peptidome as a promising tool for clinical diagnostics, providing a better understanding of SAP progression and identification of phase-specific biomarkers in pancreatitis. SUMMARY: This study reveals dynamic changes in the plasma peptidome during the progression of severe acute pancreatitis in rats. Through the identification of differentially regulated peptides, bioinformatic analysis was performed to define the altered pathways and genes, demonstrating the relationship between peptide alterations and disease progression. The 6-h time point after pancreatitis induction showed the highest number of signaling terms/pathways that characterize the inflammatory phase of the disease. In subsequent moments, the enrichment of pathways related to infection and the regulation of the actin cytoskeleton at 12- and 24-h post-pancreatitis induction suggests that this period is associated with the process of bacterial translocation and pancreatic necrosis infection. Therefore, the peptide profile and pathways may have implications for defining prognosis and early diagnosis of infection. - Source: PubMed
Publication date: 2025/11/29
Rasslan RobertoKoike Marcia KiyomiMachado Marcel Cerqueira CesarMartucci Luiz FelipeIwai Leo KeiSantos Eichler Rosangela Aparecida DosUtiyama Edivaldo MassazoFerro Emer SuavinhoMontero Edna Frasson de Souza - Children of patients with nephrolithiasis (NL) are highly susceptible to stone development. Abnormal urinary mineral excretion and elevated protein/albumin excretion rates have been reported in disease-free children of patients with NL. Increased protein excretion in these children could be associated with the risk of stone formation. - Source: PubMed
Publication date: 2025/10/31
Mingmongkol SupawadeeKalpongnukul NuttiyaSomparn PoorichayaPisitkun TrairakUngjaroenwathana WattanachaiTosukhowong PiyaratanaDissayabutra Thasinas