LNA_T 10 umol scale
- Known as:
- LNA_T 10 umol scale
- Catalog number:
- 26-6520-10
- Product Quantity:
- 1Each
- Category:
- -
- Supplier:
- Gene Link
- Gene target:
- LNA_T 10 umol scale
Related products to: LNA_T 10 umol scale
Related articles to: LNA_T 10 umol scale
- Vitiligo is a chronic autoimmune disorder characterized by melanocyte loss and depigmented skin patches. Effective treatment options are limited, and therapeutic progress has been hindered by incomplete understanding of its precise pathogenic mechanisms. We aimed to identify candidate protein biomarkers and therapeutic targets for vitiligo by integrating large-scale proteomics and genomic data using Mendelian randomization (MR). - Source: PubMed
Liu LinliDeng LingliPan XingyuChen JinYu Chunshui - Bladder cancer remains a significant global health challenge with a high mortality rate despite advancements in treatment modalities. Metabolic alterations serve as crucial contributors to cancer progression, particularly influencing tumor aggressiveness and patient outcomes. Therefore, this study aimed to identify and characterize metabolic hubs associated with disease progression and tumor aggressiveness in bladder cancer. - Source: PubMed
Publication date: 2025/06/23
Zhang JianFan XiaosongXu XuHan YichaoYu WeixingYang BichengChen YanlingZhang Shaolin - In this study, we investigated for cell proliferative and adipogenic differentiation inhibitory activities of chondroitin sulfate (CS) from cartilaginous fish: mako shark (Isurus oxyrinchus, spine part, Ms-CS), blue shark (Prionace glauca, spine part, Bs-CS), sharpspine skate (Okamejei acutispina, head and tail parts, Sp-CS) and stingray (Dasyatis akajei, head part, St-CS) on 3T3-L1 cells. Most of the CSs from cartilaginous fish showed concentration-dependent cell proliferative activity of 3T3-L1 cells within the retrieved concentration range (0-1,000 μg/mL), while under induction of adipocyte differentiation, they inhibited lipid accumulation. In particular, Ms-CS and Sp-CS were highly active in inhibiting lipid accumulation in the cells. The present study revealed that cartilaginous fish-derived CS has inhibitory activity on 3T3-L1 adipocyte differentiation by suppressing lipid droplet accumulation, although the degree of suppression varied depending on the composition of the CS and its origin. In addition, a significant increase in chondroitin sulfate N-acetylgalactosaminyltransferase 2 (Csgalnact2) expression of the Sp-CS group at the concentration of 500 µg/mL was observed. Csgalnact2 expression is associated with chondroitin N-acetylgalactosaminyltransferase-2 (ChGn-2), one of the glycosyltransferases that catalyzes the chain initiation and elongation of the CS backbone in its biosynthesis. Exogenous CS from cartilaginous fishes increased Csgalnact2 expression, although further studies are needed to confirm changes in CS biosynthesis. We observed reduced lipid accumulation in differentiated 3T3-L1 cells. Our findings highlight the role of CS polysaccharides, in inhibiting adipogenesis, even though further investigation is required to understand the underlying mechanism. - Source: PubMed
Publication date: 2025/03/10
Cahyadi Danang DwiWarita KatsuhikoTakeda-Okuda NaokoTamura Jun-IchiHosaka Yoshinao Z - Space exploration has progressed from contemporary discoveries to current endeavors, such as space tourism and Mars missions. As human activity in space accelerates, understanding the physiological effects of microgravity on the human body is becoming increasingly critical. This study analyzes transcriptomic data from human cell lines exposed to microgravity, investigates its effects on gene expression, and identifies potential therapeutic interventions for health challenges posed by spaceflight. Our analysis identified five under-expressed genes (, , , , ) and six over-expressed genes (, , , , , ), all of which exhibited distinct expression patterns in response to microgravity. Enrichment analysis highlighted significant biological functions influenced by these conditions, while in silico drug repurposing identified potential modulators that could counteract these changes. This study introduces a novel approach to addressing health challenges during space missions by repurposing existing drugs and identifies specific genes and pathways as potential biomarkers for microgravity effects on human health. Our findings represent the first systematic effort to repurpose drugs for spaceflight, establishing a foundation for the development of targeted therapies for astronauts. Future research should aim to validate these findings in authentic space environments and explore broader biological impacts. - Source: PubMed
Publication date: 2025/02/02
Galčenko KarinaBourdakou Marilena MSpyrou George M - Ovarian cancer is one of the leading causes of cancer-related death among women. CSGALNACT2 is a vital Golgi transferase and is related to a variety of human diseases. However, its expression pattern and function in ovarian cancer remain uncertain. - Source: PubMed
Publication date: 2023/12/12
Ma MingjunWang ChaoWu MeixuanGu SijiaYang JianiZhang YueCheng ShanshanXu ShilinZhang MinghaiWu YongsongZhao YaqianTian XiuVoon Dominic Chih-ChengTakahashi ChiakiSheng JindanWang Yu