CXCL10 (IP_10) Whole Serum Human
- Known as:
- CXCL10 (IP_10) Serum Human
- Catalog number:
- RS-80CX10
- Product Quantity:
- 1.0 mL
- Category:
- -
- Supplier:
- ICL I.C.L
- Gene target:
- CXCL10 (IP_10) Whole Serum Human
Related genes to: CXCL10 (IP_10) Whole Serum Human
- Gene:
- BBIP1 NIH gene
- Name:
- BBSome interacting protein 1
- Previous symbol:
- NCRNA00081
- Synonyms:
- bA348N5.3, BBIP10, BBS18
- Chromosome:
- 10q25.2
- Locus Type:
- gene with protein product
- Date approved:
- 2008-09-02
- Date modifiied:
- 2016-10-05
- Gene:
- CXCL10 NIH gene
- Name:
- C-X-C motif chemokine ligand 10
- Previous symbol:
- INP10, SCYB10
- Synonyms:
- IFI10, IP-10, crg-2, mob-1, C7, gIP-10
- Chromosome:
- 4q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-12-09
- Date modifiied:
- 2016-10-05
- Gene:
- CXCR3 NIH gene
- Name:
- C-X-C motif chemokine receptor 3
- Previous symbol:
- GPR9
- Synonyms:
- CKR-L2, CMKAR3, IP10-R, MigR, CD183
- Chromosome:
- Xq13.1
- Locus Type:
- gene with protein product
- Date approved:
- 1994-11-01
- Date modifiied:
- 2016-10-05
- Gene:
- MED24 NIH gene
- Name:
- mediator complex subunit 24
- Previous symbol:
- THRAP4, CRSP4
- Synonyms:
- TRAP100, KIAA0130, DRIP100, CRSP100, MED5
- Chromosome:
- 17q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-01-30
- Date modifiied:
- 2016-10-05
- Gene:
- PPIAP10 NIH gene
- Name:
- peptidylprolyl isomerase A pseudogene 10
- Previous symbol:
- PPIAL2, PPIP10
- Synonyms:
- CRP
- Chromosome:
- 20q13.2
- Locus Type:
- pseudogene
- Date approved:
- 1998-10-12
- Date modifiied:
- 2017-08-21
Related products to: CXCL10 (IP_10) Whole Serum Human
Related articles to: CXCL10 (IP_10) Whole Serum Human
- Inflammation contributes to cerebrovascular disease, but prospective studies of broad immune marker panels and incident stroke are limited. We aimed to identify plasma immune markers independently associated with incident stroke. Stroke-free Northern Manhattan Study participants aged ≥ 50 years had 60 plasma immune-related proteins measured by Luminex. Least absolute shrinkage and selection operator (LASSO) Cox regression selected markers associated with incident all-cause stroke. Selected markers were tested in Cox models of stroke risk sequentially adjusted for vascular risk, cardiac comorbidities, interleukin-6, interleukin-1β, tumor necrosis factor-α, and white matter hyperintensity volume (WMHV). Ischemic stroke was a secondary outcome, and bootstrap resampling provided internal validation. Among 1175 participants (mean age 70 ± 9 years; 60% women; 67% Hispanic), 130 strokes, 101 (78%) ischemic, occurred over a median of 14 years. LASSO selected only C-X-C motif chemokine ligands 9 and 10 (CXCL9 and CXCL10). Each 1-standard deviation greater CXCL10 was associated with 20% greater all-cause stroke risk after adjustment for vascular risk, cardiac comorbidities, and inflammatory cytokines (HR 1.20; 95%CI 1.04-1.38). The association persisted after WMHV adjustment (HR 1.18; 95%CI 1.02-1.37), was similar for ischemic stroke (HR 1.19; 95%CI 1.01-1.41), and was stable across bootstrap resamples. CXCL9 was not independently associated with stroke. In a multiethnic urban aging cohort followed prospectively for over a decade, baseline plasma CXCL10, also known as interferon-γ-induced protein 10 (IP-10), was independently associated with incident stroke. CXCL10 may mark interferon-γ-responsive immune activity linked to cerebrovascular vulnerability. Whether CXCL10 signals a modifiable pathway for stroke prevention warrants investigation. - Source: PubMed
Publication date: 2026/10/02
Nafeli Shahrestani MohammadAgudelo ChristianGardener HannahVeledar EmirSantiago Jose ADi Tullio Marco RDella-Morte DavidAimagambetova BotagozGutierrez JoseHornig MadyElkind Mitchell S VSong HyunWright Clinton BTom Sarah ERundek Tatjana - Hypoxia-inducible factor 1 (HIF-1) orchestrates the transcriptional regulation of thousands of genes involved in breast cancer (BC) progression. Here, we identified protein phosphatase 2A (PP2A) methylesterase 1 (PPME1) as a critical HIF-1 target gene that drives oncogenic signaling under hypoxic conditions. In BC cells, HIF-1-dependent PPME1 expression caused inhibition of the PP2A catalytic subunit (PP2Ac), thereby diminishing PP2A activity, which led to AKT activation, phosphorylation of β-catenin, and its nuclear translocation. Nuclear β-catenin cooperates with HIF-1 to promote BC stem cell specification by activating transcription of the NANOG and KLF4 genes, which encode pluripotency factors, and to drive immune evasion by activating transcription of VEGFA, which recruits and polarizes immunosuppressive tumor-associated macrophages and ISG20, which represses STAT1/IRF1-dependent expression of CXCL10, thereby impairing CD8+ T cell recruitment. In vivo, PPME1 knockdown altered the tumor immune microenvironment, enhanced antitumor immunity, and synergized with anti-CTLA-4 immunotherapy to enable complete tumor eradication. These findings establish PPME1 as a critical regulator linking hypoxia signaling, stemness, and immune evasion and highlight its potential as a BC therapeutic target in combination with immune checkpoint blockade. - Source: PubMed
Publication date: 2026/10/01
Lyu YajingTalwar VarenYang YongkangKang Si-SimLi ShuyiSalman ShaimaDrehmer DaianaWang YufengChen ChelseyRamu VijayKim SujinPark DylanHuang Tina Yi-TingDatan EmmanuelDordai DominicSchneck Jonathan PSemenza Gregg L - Retreatment with BCG alone is recommended for patients with Bacillus Calmette-Guérin (BCG)-exposed non-muscle-invasive bladder cancer (NMIBC), yet ∼50% recur and become "BCG-unresponsive." Strategies to improve the efficacy of BCG retreatment are urgently needed. - Source: PubMed
Publication date: 2026/10/01
Gaffney Christopher DAlam Syed MuneebWald GalSjoberg DanielEichholz JordanSarungbam JudyD'Souza NeetaLavery JessicaHernandez ChristianTomerlein MorganZagajeski PatriciaHildreth Kara WorthDonat SherriSmith RobertDonahue TimothyGoh AlvinBochner BernardAl-Ahmadie HikmatPietzak Eugene - SARS-CoV-2-associated hepatobiliary injury and biliary atresia (BA) differ markedly in etiology and biological context, but both involve injury to the biliary epithelial compartment. Here, we performed integrative transcriptomic and single-cell analyses to investigate whether these distinct hepatobiliary injury contexts converge on a shared cholangiocyte-associated inflammatory host-response program. Bulk transcriptomic datasets from SARS-CoV-2-infected human liver organoids and BA liver tissues were integrated to identify shared transcriptional alterations, followed by functional enrichment, protein-protein interaction, regulatory network, drug-gene interaction, and molecular docking analyses. Single-nucleus and single-cell datasets were used to determine the cellular localization of the shared program, and key findings were further assessed in BA liver tissues and cultured human cholangiocytes exposed to poly(I:C). We identified an expanded exploratory set of 164 shared genes and a stringent -adjusted core of 52 genes. Both sets consistently implicated antiviral defense, type I and type II interferon signaling, double-stranded RNA responses, and cytokine and chemokine signaling. STAT1, ISG15, and CXCL10 were retained in the stringent core and remained central components of the interaction network. In COVID-19 liver single-nucleus data, donor-level analysis showed preferential localization of the shared signature to cholangiocytes, whose mean scores were significantly higher than those of all other hepatic cells combined ( = 0.00368). A similar pattern was observed descriptively in our BA single-nucleus dataset and further supported by an independent BA single-cell cohort. Tissue immunofluorescence spatially associated pSTAT1, total STAT1, and ISG15 signals with KRT19-positive ductular structures, whereas CXCL10 was predominantly periductal. Poly(I:C) stimulation induced representative components of the program in cultured cholangiocytes. Computational analyses retained mefloquine among the top-ranked exploratory candidates. Collectively, these findings support a convergent cholangiocyte-associated interferon/inflammatory host-response program in BA and SARS-CoV-2-associated hepatobiliary injury. They indicate molecular association rather than a common etiology or causal relationship and provide testable hypotheses for further investigation of biliary epithelial inflammatory responses. - Source: PubMed
Publication date: 2026/09/16
Wa YujuanGuan RongDu ZhanweiLin RouchenCui ShiyuGuang JiangleiXu LidanJi WeiYang QianCui QingboWang HaoSun Wenjing - Marmosets (MAR, Callithrix jacchus) are nonhuman primates extensively studied in a broad array of preclinical biomedical research areas. However, the limited number of available immunological reagents remains a critical shortcoming of these models. We successfully developed monoclonal antibodies (mAbs) pairs that can be used in immunoassays for the identification and quantification of the biomarkers of inflammation C-reactive protein (CRP), CXCL-10 (IP-10), interleukin (IL)-4, IL-6, and IL-10. Recombinant MAR protein variants were produced in mammalian cells, purified and used for mice immunization. Hybridoma clones were selected first for their capacity to bind the recombinant proteins. All possible pair combinations of these mAbs were then tested for their capacity to identify their targets in MAR-derived samples. These MAR samples consisted of supernatant of PBMCs exposed ex vivo to different stimulants, and plasma samples from animals stimulated in vivo with a low-dose intravenous LPS inoculation. The majority of the mAbs that recognized the recombinant proteins failed to bind to the MAR-derived homologs. However, we found MAR-derived reactive mAbs and selected pairs with optimal sensitivity and signal-to-noise ratio for immunoassays that included Luminex multiplexing assays, ELISA, and ELISpot assays. These immunoreagents and assays will improve the translational value of different MAR biomedical models. - Source: PubMed
Publication date: 2026/09/23
Lambrou EktorasHallengärd DavidTurbow BenjaminCallery JessicaHodara VidaKing JonathanRoss CorinnaAhlborg NiklasMakower BartekGiavedoni Luis D