Human CXCL10 (IP_10) ELISA KIT
- Known as:
- Human CXCL10 (IP_10) Enzyme-linked immunosorbent assay test KIT
- Catalog number:
- E-80CX10
- Product Quantity:
- 1 x 96 well plate
- Category:
- Peptides
- Supplier:
- ICL I.C.L
- Gene target:
- Human CXCL10 (IP_10) ELISA KIT
Related genes to: Human CXCL10 (IP_10) ELISA KIT
- Gene:
- BBIP1 NIH gene
- Name:
- BBSome interacting protein 1
- Previous symbol:
- NCRNA00081
- Synonyms:
- bA348N5.3, BBIP10, BBS18
- Chromosome:
- 10q25.2
- Locus Type:
- gene with protein product
- Date approved:
- 2008-09-02
- Date modifiied:
- 2016-10-05
- Gene:
- CXCL10 NIH gene
- Name:
- C-X-C motif chemokine ligand 10
- Previous symbol:
- INP10, SCYB10
- Synonyms:
- IFI10, IP-10, crg-2, mob-1, C7, gIP-10
- Chromosome:
- 4q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-12-09
- Date modifiied:
- 2016-10-05
- Gene:
- CXCR3 NIH gene
- Name:
- C-X-C motif chemokine receptor 3
- Previous symbol:
- GPR9
- Synonyms:
- CKR-L2, CMKAR3, IP10-R, MigR, CD183
- Chromosome:
- Xq13.1
- Locus Type:
- gene with protein product
- Date approved:
- 1994-11-01
- Date modifiied:
- 2016-10-05
- Gene:
- MED24 NIH gene
- Name:
- mediator complex subunit 24
- Previous symbol:
- THRAP4, CRSP4
- Synonyms:
- TRAP100, KIAA0130, DRIP100, CRSP100, MED5
- Chromosome:
- 17q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-01-30
- Date modifiied:
- 2016-10-05
- Gene:
- PPIAP10 NIH gene
- Name:
- peptidylprolyl isomerase A pseudogene 10
- Previous symbol:
- PPIAL2, PPIP10
- Synonyms:
- CRP
- Chromosome:
- 20q13.2
- Locus Type:
- pseudogene
- Date approved:
- 1998-10-12
- Date modifiied:
- 2017-08-21
Related products to: Human CXCL10 (IP_10) ELISA KIT
Related articles to: Human CXCL10 (IP_10) ELISA KIT
- An 84-year-old woman presented with a two months history of progressive bilateral lower limb weakness and bladder bowel disfunction. Neurological examination revealed spastic paraplegia and anti HTLV-1 antibodies were positive in the serum and cerebrospinal fluid. Due to the rapid progression along with the elevation of neopterin and CXCL-10 in the cerebrospinal fluid, the diagnosis of rapidly progressive HTLV-1 associated myelopathy (HAM) was made. Chest X-ray and CT coincidentally revealed diffuse micronodular opacities, nodular in various sizes, and interlobular septal thickening. HTLV-1 associated bronchioalveolar disorder was the most likely diagnosis. Steroid therapy was effective against both spastic paraplegia and pulmonary lesions. Although the pulmonary lesions were identified incidentally in our case, screening for pulmonary lesions is important in patients with spastic paraplegia as it may lead to early diagnosis of HAM. - Source: PubMed
Publication date: 2026/07/08
Demizu RirinaOtsuka YoshihisaTamada RyogoMizutani Yu - Transplant-associated cutaneous squamous cell carcinoma (TSCC) is one of the most common malignancies in solid organ transplant recipients and is strongly associated with long-term immunosuppression. However, the transcriptional programs and molecular mechanisms through which chronic immunosuppression reshapes intratumoral CD8⁺ T-cell differentiation remain poorly understood. - Source: PubMed
Publication date: 2026/07/01
Chen YanxuWen TianruiNie WeijianWu ShenghuiZhang Qiang - - Source: PubMed
Publication date: 2026/07/08
Assis de Souza AlvaroPeeters AnnemiekBost DouglasBaan CarlaBoer KarinHesselink Dennis A - Prognostic assessment of tumor patients in the surgical intensive care unit (SICU) remains challenging due to the complex interplay between systemic inflammation and immune dysfunction. In this study, we performed integrative transcriptomic profiling of peripheral blood mononuclear cells (PBMCs) from 112 SICU patients with solid tumors, aiming to identify immune-related signatures predictive of 30-day survival. High-throughput RNA sequencing quantified 19,832 expressed genes, while computational immune deconvolution using CIBERSORTx estimated relative fractions of 22 immune cell types. Differential expression analysis revealed 432 upregulated and 287 downregulated genes in non-survivors, with notable elevation of CXCL10 (27.5 ± 4.6 TPM vs. 12.3 ± 3.1 TPM in survivors, p = 0.002) and IL6 (19.4 ± 3.9 vs. 9.1 ± 2.7 TPM, p = 0.004), accompanied by reduced CD8A (12.3 ± 3.6 vs. 28.1 ± 4.2 TPM, p = 0.006) and GZMB (7.2 ± 1.9 vs. 15.4 ± 3.0 TPM, p = 0.008). Correspondingly, high-risk patients demonstrated decreased cytotoxic T lymphocyte fractions (12.3% ± 3.6% vs. 27.8% ± 4.2%, p = 2.6 × 10) and NK cells (5.2% ± 1.3% vs. 11.1% ± 2.1%, p = 1.9 × 10) with increased neutrophils (45.2% ± 5.1% vs. 31.7% ± 4.8%, p = 3.2 × 10). A Prognostic Immune Score (PIS), constructed based on 12 key immune-related genes, achieved a concordance index of 0.81, effectively stratifying patients into high- and low-risk groups with 30-day survival rates of 42.5% and 86.1%, respectively (log-rank p < 0.001). Subgroup analyses confirmed that the PIS retained predictive accuracy across tumor types and APACHE II strata, underscoring its robustness. These findings demonstrate that integrative transcriptomic and immune profiling provides a quantitative framework for early risk stratification in SICU tumor patients and identifies actionable biomarkers for potential immunomodulatory interventions. - Source: PubMed
Publication date: 2026/06/23
Chen ChangjinZhong HengquanOuyang SongmaoLai JiyingWu Chaoyu - Cervical insufficiency (CI), characterized by painless cervical dilation during the second trimester, is a major cause of preterm birth. However, the local microenvironment associated with CI, particularly the roles of immune-checkpoint regulators (ICRs) and inflammatory cytokines and chemokines (ICKs), remains poorly understood. This study aimed to investigate the changes in ICRs and ICKs before and after cervical cerclage, as well as to identify predictors of preterm birth in patients with CI. - Source: PubMed
Publication date: 2026/06/23
Jeong SeriLee Keun-YoungSon Ga-HyunLee Kyong-NoCho Won KyongChoi HoseongLee JonghyunKwak-Kim Joanne